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Specialty: Stem Cells
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Total 184 results found since Jan 2013.
Efficacy and Safety of Bone Marrow Derived Stem Cell Therapy for Ischemic Stroke: Evidence from Network Meta-analysis
CONCLUSION: Using stem cell transplantation was associated with reduced risk of death and improved functional outcomes in patients with ischemic stroke. Additional large trials are warranted to provide more conclusive evidence.PMID:37612871 | DOI:10.2174/1574888X18666230823094531
Source: Current Stem Cell Research and Therapy - August 24, 2023 Category: Stem Cells Authors: Xing Wang Jingguo Yang Chao You Xinjie Bao Lu Ma Source Type: research
Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research
Functional roles of mesenchymal stem cell-derived exosomes in ischemic stroke treatment
Curr Stem Cell Res Ther. 2022 Dec 22. doi: 10.2174/1574888X18666221222123818. Online ahead of print.ABSTRACTStroke is a life-threatening disease and one of the leading causes of death and physical disability worldwide. Currently, no drugs on the market promote neural recovery after stroke insult, and spontaneous remodeling processes are limited to induce recovery in the ischemic regions. Therefore, promoting a cell-based therapy has been needed to elevate the endogenous recovery process. Mesenchymal stem cells (MSCs) have been regarded as candidate cell sources for therapeutic purposes of ischemic stroke, and their therape...
Source: Current Stem Cell Research and Therapy - December 25, 2022 Category: Stem Cells Authors: Maryam Farzaneh Seyed Esmaeil Khoshnam Source Type: research
Experimental study on the protective mechanism of mesenchymal stem cells against central nervous system injury in heat stroke
CONCLUSIONS: These results suggested that MSCs injection may provide therapeutic effects in HS of rats by improving the liver and kidney function, reducing the CNS damage. Moreover, MSCs injection inhibited the brain inflammatory response of HS rats, and the BDNF-TrkB and P38/MAPK signal pathways may be involved.which may provide a potential mechanism for HS therapy by MSCs administration.PMID:35546753 | DOI:10.2174/1574888X17666220511144254
Source: Current Stem Cell Research and Therapy - May 13, 2022 Category: Stem Cells Authors: Rui Yuan Lu Wang Zi-Hui Deng Meng-Meng Yang Yan Zhao Jie Hu Yu Zhang Yun Li Meng Liu Shi-Fei Liu Fei-Hu Zhou None Hanyu-Zhu Hong-Jun Kang Source Type: research
Preclinical Studies of Neural Stem/Progenitor Cell Therapy for Ischemic Stroke: A Systematic Review
CONCLUSION: Most of the preclinical studies reported statistically significant effects and very few adverse reactions. Transplantation of NSPCs for ischemic stroke still needs to be optimized for several key factors. A standardized treatment outcome assessment could ease the translation of evidence in clinical settings.PMID:35410620 | DOI:10.2174/1574888X17666220410221905
Source: Current Stem Cell Research and Therapy - April 12, 2022 Category: Stem Cells Authors: Mengze Zhang Kan Wang Chunran Xue Chong Xie Ze Wang Yaying Song Haojun Yu Yong Hao Yangtai Guan Source Type: research
Exploring the role of stem cell therapy in treating neurodegenerative diseases: Challenges and current perspectives
Curr Stem Cell Res Ther. 2021 Aug 9. doi: 10.2174/1574888X16666210810103838. Online ahead of print.ABSTRACTSeveral human neurological disorders such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis; Huntington's disease, spinal cord injury, multiple sclerosis, and brain stroke, are caused by the injury to neurons or glial cells. The recent years have witnessed the successful generation of neurons and glia cells driving efforts to develop stem-cell-based therapies for patients to combat a broad spectrum of human neurological diseases. The inadequacy of suitable cell types for cell replacement thera...
Source: Current Stem Cell Research and Therapy - February 9, 2022 Category: Stem Cells Authors: Nidhi Puranik Ananta Prasad Arukha Shiv Kumar Yadav Dhananjay Yadav Jun O Jin Source Type: research
