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Specialty: Nanotechnology

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Total 106 results found since Jan 2013.

Fabrication of multifunctional metal –organic frameworks nanoparticles via layer-by-layer self-assembly to efficiently discover PSD95-nNOS uncouplers for stroke treatment
Disruption of the postsynaptic density protein-95 (PSD95) —neuronal nitric oxide synthase (nNOS) coupling is an effective way to treat ischemic stroke, however, it still faces some challenges, especially lack o...
Source: Journal of Nanobiotechnology - August 13, 2022 Category: Nanotechnology Authors: Yingying Ding, Yang Jin, Tao Peng, Yankun Gao, Yang Zang, Hongliang He, Fei Li, Yu Zhang, Hongjuan Zhang and Lina Chen Tags: Research Source Type: research

An Ultrasound ‐Responsive Theranostic Cyclodextrin‐Loaded Nanoparticle for Multimodal Imaging and Therapy for Atherosclerosis
This study reports CD delivery via air-trapped polybutylcyanoacrylate nanoparticles (with diameters of 388  ± 34 nm) loaded with CD (CDNPs). The multimodal contrast ability of these nanoparticles after being loaded with IR780 dye in mice is demonstrated using ultrasound and near-infrared imaging. It is shown that CDNPs enhance the cellular uptake of CD in murine cells. In an ApoE–/– mouse model of atherosclerosis, treatment with CDNPs significantly improves the anti-atherosclerotic efficacy of CD. Ultrasound triggering further improves CD uptake, highlighting that CDNPs can be used for ultrasound imaging and ultras...
Source: Small - June 17, 2022 Category: Nanotechnology Authors: Sourabh Mehta, Viktoria Bongcaron, Tien K Nguyen, Yugandhara Jirwanka, Ana Maluenda, Aidan P G Walsh, Jathushan Palasubramaniam, Mark D Hulett, Rohit Srivastava, Alex Bobik, Xiaowei Wang, Karlheinz Peter Tags: Research Article Source Type: research

Magnetic Nanobubble Mechanical Stress Induces the Piezo1 ‐Ca2+‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke
Magnetic nanobubbles (MNBs) assembled from magnetic nanoparticles are fabricated. When interacting with neural stem cells (NSCs), these MNB nanostructures can contract and expand with volumetric oscillation, leading to a change in intramembrane mechanical properties. Therefore, MNBs can serve as acoustic sensors to transduce Piezo1-Ca2+- triggered BMP2/Smad signals regulating NSC development and can be tracked using magnetic resonance and ultrasound dual imaging. AbstractNeural stem cells (NSCs) are used to treat various nervous system diseases because of their self-renewal ability and multidirectional differentiation pote...
Source: Small - June 9, 2022 Category: Nanotechnology Authors: Jing Li, Yao Zhang, Zhichao Lou, Mingxi Li, Lin Cui, Zhenrong Yang, Lijuan Zhang, Yu Zhang, Ning Gu, Fang Yang Tags: Research Article Source Type: research

Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice
Ischemic stroke is one of the main causes of death and disability in the world. The treatment for ischemic stroke is to restore blood perfusion as soon as possible. However, when ischemic brain tissue is re-pe...
Source: Journal of Nanobiotechnology - June 3, 2022 Category: Nanotechnology Authors: Daozhou Liu, Qifeng Ji, Ying Cheng, Miao Liu, Bangle Zhang, Qibing Mei, Menglei Huan and Siyuan Zhou Tags: Research Source Type: research

Targeted delivery of fat extract by platelet membrane-cloaked nanocarriers for the treatment of ischemic stroke
Our previous studies suggest that human fat extract (FE) contains a variety of angiogenic factors and may provide an alternative treatment option for stroke. However, the therapeutic effect is largely limited ...
Source: Journal of Nanobiotechnology - May 31, 2022 Category: Nanotechnology Authors: Cheng Wang, Xuewei Yang, Yixu Jiang, Lin Qi, Deli Zhuge, Tongtong Xu, Yiyan Guo, Mingwu Deng, Wenjie Zhang, Dongyan Tian, Qingqing Yin, Li Li, Zhijun Zhang, Yongting Wang, Guo-Yuan Yang, Yijie Chen & hellip; Tags: Research Source Type: research

Advances of nano drug delivery system for the theranostics of ischemic stroke
From the global perspective, stroke refers to a highly common cause of disability and death. Ischemic stroke (IS), attributed to blood vessel blockage, preventing the flow of blood to brain, acts as the most c...
Source: Journal of Nanobiotechnology - May 31, 2022 Category: Nanotechnology Authors: Wei Lv, Yijiao Liu, Shengnan Li, Lingyan Lv, Hongdan Lu and Hongliang Xin Tags: Review Source Type: research

Magnetic Nanobubble Mechanical Stress Induces the Piezo1 ‐Ca2+‐BMP2/Smad Pathway to Modulate Neural Stem Cell Fate and MRI/Ultrasound Dual Imaging Surveillance for Ischemic Stroke
Magnetic nanobubbles (MNBs) assembled from magnetic nanoparticles are fabricated. When interacting with neural stem cells (NSCs), these MNB nanostructures can contract and expand with volumetric oscillation, leading to a change in intramembrane mechanical properties. Therefore, MNBs can serve as acoustic sensors to transduce Piezo1-Ca2+- triggered BMP2/Smad signals regulating NSC development and can be tracked using magnetic resonance and ultrasound dual imaging. AbstractNeural stem cells (NSCs) are used to treat various nervous system diseases because of their self-renewal ability and multidirectional differentiation pote...
Source: Small - May 12, 2022 Category: Nanotechnology Authors: Jing Li, Yao Zhang, Zhichao Lou, Mingxi Li, Lin Cui, Zhenrong Yang, Lijuan Zhang, Yu Zhang, Ning Gu, Fang Yang Tags: Research Article Source Type: research

Targeted delivery of edaravone by liposomes for the treatment of ischemic stroke
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - May 4, 2022 Category: Nanotechnology Authors: Meng-Meng Song Jing Chen Shu-Ming Ye Da-Peng Lu Gui-Yang Zhang Rui Liu Yu-Xian Shen Source Type: research

Progress in Stimuli ‐Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases
Stimuli-responsive biomaterials are robustly used for the treatment of cardiovascular and cerebrovascular diseases. This review thoroughly discusses the recent advances (last 5 years) in the preclinical and clinical stage of these smart materials offering a view of their strengths and weaknesses and a glimpse of their future perspective. AbstractCardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic stroke are the leading causes of death worldwide, resulting in 16% and 11% of deaths globally. Although s...
Source: Small - March 20, 2022 Category: Nanotechnology Authors: Christos Tapeinos, Han Gao, Tom ás Bauleth‐Ramos, Hélder A. Santos Tags: Review Source Type: research

Brain Targeting, Antioxidant Polymeric Nanoparticles for Stroke Drug Delivery and Therapy
This study develops nanoparticles (NPs) consisting of a reactive oxygen species (ROS)-reactive polymer and further engineers them for targeted drug delivery to the ischemic brain through ligand-mediated interaction and thrombin-triggered shrinkability. It is demonstrated that the resulting NPs can efficiently deliver glyburide to the brain for effective stroke treatment. AbstractIschemic stroke is a leading cause of death and disability and remains without effective treatment options. Improved treatment of stroke requires efficient delivery of multimodal therapy to ischemic brain tissue with high specificity. Here, this ar...
Source: Small - March 20, 2022 Category: Nanotechnology Authors: Haoan Wu, Bin Peng, Farrah S. Mohammed, Xingchun Gao, Zhenpeng Qin, Kevin N. Sheth, Jiangbing Zhou, Zhaozhong Jiang Tags: Research Article Source Type: research

Reversible Hydration Composite Films for Evaporative Perspiration Control and Heat Stress Management
A super-hygroscopic zinc-poly(vinyl alcohol) composite film is developed to improve thermal comfort for healthcare workers. With the composite film attached to the personal protective equipment, the water vapor accumulated is rapidly absorbed by the film. A steep vapor pressure gradient is created to facilitate sweat evaporation and relieve the heat stress experienced by healthcare workers. AbstractDonning of personal protective equipment (PPE) in the healthcare sector has been intensified by the on-going COVID-19 pandemic around the globe. While extensive PPE provides protection, it typically limits moisture permeability ...
Source: Small - February 21, 2022 Category: Nanotechnology Authors: Jiachen Yang, Xueping Zhang, J. Justin Koh, Rensheng Deng, Saravana Kumarasamy, Yuan Xing Xu, Hao Qu, Songlin Zhang, Yaoxin Zhang, Swee Ching Tan Tags: Research Article Source Type: research

ASAP A DNA Nanostructure-Based Neuroprotectant against Neuronal Apoptosis via Inhibiting Toll-like Receptor 2 Signaling Pathway in Acute Ischemic Stroke
ACS NanoDOI: 10.1021/acsnano.1c09626
Source: ACS Nano - December 30, 2021 Category: Nanotechnology Authors: Mi Zhou, Tianxu Zhang, Bowen Zhang, Xiaolin Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, and Yunfeng Lin Source Type: research