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Specialty: Neuroscience
Condition: Dementia

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Total 167 results found since Jan 2013.

Function and regulation of cis P ‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies
Cis –trans isomerization of protein plays an important role in protein folding, function, and degradation, which is regulated by peptidyl-proline isomerases (PPIases). The cis P-tau but not trans P-tau is resistant to protein dephosphorylation and degradation and also prone to protein aggregation and serves as an early driver of multiple neurodegenerative disease including Alzheimer disease (AD), traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), and vascular contributions to cognitive impairment and dementia (VCID). Cis P-tau antibody is the only clinical-stage therapeutic fo r AD that has shown the e...
Source: Journal of Neurochemistry - August 29, 2023 Category: Neuroscience Authors: Ruizhi Wang, Kun Ping Lu, Xiao Zhen Zhou Tags: REVIEW Source Type: research

Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study
ConclusionMemTrax (MTx) is valid and effective for screening for PSCI among target patients and is a potentially valuable and practical tool in the clinical follow-up, monitoring, and case management of PSCI.
Source: Frontiers in Human Neuroscience - July 17, 2023 Category: Neuroscience Source Type: research

Preface: Special issue “”
The special issue “Brain Proteostasis in Health and Disease” features both original and review articles written by specialists in the field of protein homeostasis. Deregulation of adequate proteostasis may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore , delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue covers the roles of protein homeostasis in several me chanisms t...
Source: Journal of Neurochemistry - July 7, 2023 Category: Neuroscience Authors: Mychael V. Lourenco Tags: EDITORIAL Source Type: research

Preface: Special issue “Brain Proteostasis in Health and Disease”
The special issue “Brain Proteostasis in Health and Disease” features both original and review articles written by specialists in the field of protein homeostasis. Deregulation of adequate proteostasis may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore , delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue covers the roles of protein homeostasis in several me chanisms t...
Source: Journal of Neurochemistry - July 6, 2023 Category: Neuroscience Authors: Mychael V. Lourenco Tags: EDITORIAL Source Type: research

Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats
In this study, we established the VD model of rats by bilateral carotid artery occlusion to explore the neuroprotective effect of EDB and its mechanism. Morris Water Maze test was applied to assess the cognitive function of rats. H&E and TUNEL staining were applied to observe the cellular structure of the hippocampus. Immunofluorescence labeling was used to observe the proliferation of astrocytes and microglia. ELISA was applied to examine the levels of TNF-α, IL-1β and IL-6, and RT-PCR was applied to examine their mRNA expression levels. Western blotting was applied to examine apoptosis-related proteins (Bax, Bcl-2,...
Source: Neurochemical Research - June 20, 2023 Category: Neuroscience Authors: Jiawei Zhang Yining Xiao Hongna Liu Lili Xu Xing Guo Yaran Gao Meixi Li Jing Xu Qianqian Qi Peiyuan Lv Source Type: research

Associations of circulating metabolites with cerebral white matter hyperintensities
This study found that the majority of lipoprotein subclasses and lipid concentration are strongly associated with WMH volume, and several non-lipid-related traits such as Gly, MUFA, and degree of unsaturation present certain effects on WMH. In addition, the results revealed the sex and age specificities indicating the distinct metabolomic features impact WMH in diverse individuals. These results demonstrated the power of detailed metabolite profiling for biomarker discovery, which can yield an improved molecular understanding of disease mechanisms. AbstractWhite matter hyperintensities (WMH) are the most compelling risk fa...
Source: Journal of Neurochemistry - May 25, 2023 Category: Neuroscience Authors: Yan Sun, Yu Guo, Hong ‐Qi Li, Lan Tan, Jian‐Feng Feng, Wei Cheng, Jin‐Tai Yu Tags: ORIGINAL ARTICLE Source Type: research

Is Matrix Metalloproteinase-9 Associated with Post-Stroke Cognitive Impairment or Dementia?
J Integr Neurosci. 2022 Sep 22;21(6):160. doi: 10.31083/j.jin2106160.NO ABSTRACTPMID:36424752 | DOI:10.31083/j.jin2106160
Source: Journal of Integrative Neuroscience - November 25, 2022 Category: Neuroscience Authors: Jianhua Zhao Fangli Yang Xue Peng Qing Li Fan Wang Zhixiu Xu Ruiyan Cai Danxia Ji Jian Zhang Minghua Wang Qiong Li Sibei Ji Shaomin Li Source Type: research