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Specialty: Dermatology

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Total 354 results found since Jan 2013.

The association between cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta ‐analysis
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: J.P. Thyssen, A. ‐S. Halling‐Overgaard, Y.M.F. Andersen, G. Gislason, L. Skov, A. Egeberg Tags: Systematic Review Source Type: research

The association between cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis.
This article is protected by copyright. All rights reserved. PMID: 29210061 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - December 6, 2017 Category: Dermatology Authors: Thyssen JP, Halling-Overgaard AS, Andersen YMF, Gislason G, Skov L, Egeberg A Tags: Br J Dermatol Source Type: research

Nifedipine cream versus sildenafil cream for patients with secondary Raynaud phenomenon: A randomized, double-blind, controlled pilot study
The objective of the study was to compare the vasodilator efficacy of topical 10% nifedipine versus 5% sildenafil in subjects with secondary RP associated with connective tissue disease. A prospective study was performed including 10 patients with secondary RP. We excluded tobacco smokers, patients with primary RP, hypotension, hypertension, myocardial infarction, stroke, or arrhythmia.
Source: Journal of the American Academy of Dermatology - December 12, 2017 Category: Dermatology Authors: Ximena Wortsman, Pablo Del Barrio-D íaz, Rodrigo Meza-Romero, Christine Poehls-Risco, Cristián Vera-Kellet Tags: Research letter Source Type: research

Local heat urticaria.
We present a 38-year-old woman with local heat urticaria confirmed by heat provocation testing. Heat urticaria is a rare form of physical urticaria that istriggered by exposure to a heat source, such as hot water or sunlight. Although it is commonly localized and immediate, generalized and delayed onset forms exist. Treatment options include antihistamines and heat desensitization. A brisk, mechanical stroke elicited a linear wheal. Five minutes after exposure to hot water, she developed well-demarcated,erythematous blanching wheals that covered the distal forearm and entire hand. PMID: 29447656 [PubMed - in process]
Source: Dermatol Online J - December 15, 2017 Category: Dermatology Authors: White F, Cobos G, Soter NA Tags: Dermatol Online J Source Type: research

Blood vessel occlusion with erythrocyte aggregates causes burn injury progression: microvasculature dilation as a possible therapy
This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - February 25, 2018 Category: Dermatology Authors: Richard A. F. Clark, Justine Fenner, Arielle Sasson, Steve A. McClain, Adam J. Singer, Marcia G. Tonnesen Tags: Viewpoint Source Type: research

Hidradenitis suppurativa is associated with myocardial infarction, but not stroke or peripheral arterial disease of the lower extremities
British Journal of Dermatology, EarlyView.
Source: British Journal of Dermatology - January 8, 2018 Category: Dermatology Source Type: research

Crescentic splinter haemorrhages reflect stroke pathophysiology in hypereosinophilic syndrome
Australasian Journal of Dermatology, EarlyView.
Source: Australasian Journal of Dermatology - September 11, 2017 Category: Dermatology Source Type: research

Carney complex revealed by a cerebellar ischaemic stroke in a 6 ‐year‐old girl
Journal of the European Academy of Dermatology and Venereology,Volume 32, Issue 4, Page e128-e129, April 2018.
Source: Journal of the European Academy of Dermatology and Venereology - October 6, 2017 Category: Dermatology Source Type: research

830 Fabry rat skin findings demonstrate potential roles of inflammation and lipoatrophy in Fabry disease
Fabry disease is an X-linked lysosomal disease caused by α-galactosidase A deficiency. Patients experience distal extremity pain and often develop renal failure, cardiomyopathy, and stroke. Dermatological manifestations include sweating abnormalities and angiokeratomas. To gain a better understanding of disease mechanisms, we generated a Fabry rat model using CRISPR/Cas9 technology and confirmed the absence of α-galactosidase A activity in tissues. Wild type (WT) and Fabry rats were indistinguishable at young ages (weaning-6 months), but aging (9 months+) Fabry rats developed an unkempt appearance, alopecia, and xeroderma.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: J.J. Miller, O. Sokumbi, P.E. North, N.M. Dahms Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

755 Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels which lead to disfigurement, overgrowth, stroke, pain and/or life-threatening bleeding, depending on the vessel size and the body site. Therapeutic options are severely limited and multi-disciplinary management remains challenging. To investigate the pathogenesis of 160 sporadic intracranial and extracranial VMs in which known genetic causes had been excluded, sequencing of affected tissue DNA was undertaken using next generation sequencing optimised for detection of low mutant allele frequency.
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: S. Polubothu, L. Al-Olabi, K. Dowsett, K. Andrews, P. Stadnik, R. Knox, W. Baird, M. Glover, C. Moss, A. Thomas, L. Biesecker, R. Semple, E. Patton, V. Kinsler Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

096 Demographic and serologic features differentiate bullous pemphigoid with and without preceding neurologic disease
This study aimed to identify features that may differentiate BP patients with and without neurologic disease. 105 patients with BP were enrolled in this study: 75 control BP patients with no neurologic disease (CON), 10 patients with BP and a prior diagnosis of Parkinson ’s disease (BP+PD), 11 BP with dementia patients (BP+DEM), and 9 BP with stroke (BP+STR).
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: A. Miller, K. Messingham, N. Narayanan, S. Connell, J. Fairley Tags: Adaptive and Auto-Immunity Source Type: research

Psoriasis as a cardiovascular risk factor: updates and algorithmic approach.
Authors: Cozzani E, Rosa G, Burlando M, Parodi A Abstract Although psoriasis is predominantly a chronic inflammatory skin disorder, it has been known to be associated with cardiovascular disease. Patients with psoriasis, particularly with moderate to severe forms, present an increased rate of cardiovascular mortality, myocardial infarction and stroke. However the pathophysiology of the relationship between psoriasis and cardiovascular risk and comorbidities has not yet completely known. Chronic inflammation may be considered a solid link between psoriasis and related cardiovascular events. Several cytokines and inf...
Source: Giornale Italiano di Dermatologia e Venereologia - April 24, 2018 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

830 Fabry rat skin findings demonstrate potential roles of inflammation and lipoatrophy in Fabry disease
Fabry disease is an X-linked lysosomal disease caused by α-galactosidase A deficiency. Patients experience distal extremity pain and often develop renal failure, cardiomyopathy, and stroke. Dermatological manifestations include sweating abnormalities and angiokeratomas. To gain a better understanding of disease mechanisms, we generated a Fabry rat model using CRISPR/Cas9 technology and confirmed the absence of α-galactosidase A activity in tissues. Wild type (WT) and Fabry rats were indistinguishable at young ages (weaning-6 months), but aging (9 months+) Fabry rats developed an unkempt appearance, alopecia, and xeroderma.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: J.J. Miller, O. Sokumbi, P.E. North, N.M. Dahms Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research

755 Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
Sporadic vascular malformations (VMs) are complex congenital anomalies of blood vessels which lead to disfigurement, overgrowth, stroke, pain and/or life-threatening bleeding, depending on the vessel size and the body site. Therapeutic options are severely limited and multi-disciplinary management remains challenging. To investigate the pathogenesis of 160 sporadic intracranial and extracranial VMs in which known genetic causes had been excluded, sequencing of affected tissue DNA was undertaken using next generation sequencing optimised for detection of low mutant allele frequency.
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: S. Polubothu, L. Al-Olabi, K. Dowsett, K. Andrews, P. Stadnik, R. Knox, W. Baird, M. Glover, C. Moss, A. Thomas, L. Biesecker, R. Semple, E. Patton, V. Kinsler Tags: Genetic Disease, Gene Regulation, and Gene Therapy Source Type: research