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Identification of vulnerable carotid plaque with histologically validated CT-derived plaque maps
CONCLUSIONS: Carotid plaque components can be differentiated by CT using a ratio of plaque/contrast attenuation. CT-derived plaque map volumes of necrotic core help distinguished the most vulnerable plaques.ADVANCES IN KNOWLEDGE: CT-derived plaque maps based on plaque/contrast attenuation may provide new markers of carotid plaque vulnerability.PMID:37183910 | DOI:10.1259/bjr.20220982
Source: The British Journal of Radiology - May 15, 2023 Category: Radiology Authors: Daniel Rhys Obaid Ike Okonji Suk F Cheng Argyrios A Giannopoulos Pragash Kamalathevan Julian Halcox Manuel Rodriguez-Justo Toby Richards Source Type: research

Cost-effectiveness of carotid endarterectomy in symptomatic patients
CONCLUSION: Surgery may not now be clinically effective and cost-effective in those with moderate carotid stenosis. However, these results are uncertain because of the limited data on modern medical therapy and an RCT may be justified.PMID:36422995 | DOI:10.1093/bjs/znac386
Source: The British Journal of Surgery - November 24, 2022 Category: Surgery Authors: Daniel Perez-Troncoso David Epstein Alun Huw Davies Ankur Thapar Source Type: research

Carotid Endarterectomy Following Intravenous Thrombolysis in the UK
CONCLUSION: The use of ivTT before CEA in stroke patients was not associated with an increased risk of 30 day stroke, but there was an increase in the risk of neck haematoma.PMID:34088616 | DOI:10.1016/j.ejvs.2021.03.033
Source: PubMed: Eur J Vasc Endovasc ... - June 5, 2021 Category: Surgery Authors: Amundeep S Johal A Ross Naylor Arun D Pherwani Qiuju Li Panagiota Birmpili Sam Waton Richard O'Neill Jonathan R Boyle David A Cromwell Source Type: research

Timing of procedural stroke and death in asymptomatic patients undergoing carotid endarterectomy: individual patient analysis from four RCTs.
CONCLUSION: At least half of the procedural strokes in this study were ischaemic and ipsilateral to the treated artery. Half of all procedural complications occurred on the day of surgery, but one-third after day 3 when many patients had been discharged. PMID: 32162310 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - March 11, 2020 Category: Surgery Authors: Poorthuis MHF, Bulbulia R, Morris DR, Pan H, Rothwell PM, Algra A, Becquemin JP, Bonati LH, Brott TG, Brown MM, Calvet D, Eckstein HH, Fraedrich G, Gregson J, Greving JP, Hendrikse J, Howard G, Jansen O, Mas JL, Lewis SC, de Borst GJ, Halliday A, Carotid Tags: Br J Surg Source Type: research

Meta-analysis of the outcomes of treatment of internal carotid artery near occlusion.
CONCLUSION: These data suggest that BMT alone is not superior to CEA or CAS with respect to 30-day or 1-year stroke or death prevention in patients with ICANO. These patients do not appear to constitute a high-risk group for surgery, and consideration should made to including them in future RCTs of internal carotid artery interventions. PMID: 30973990 [PubMed - in process]
Source: The British Journal of Surgery - April 13, 2019 Category: Surgery Authors: Meershoek AJA, de Vries EE, Veen D, den Ruijter HM, de Borst GJ, NEON study group Tags: Br J Surg Source Type: research

Association between physical activity and sedentary behaviour on carotid atherosclerotic plaques: an epidemiological and histological study in 90 asymptomatic patients.
CONCLUSION: In this cross-sectional study of asymptomatic patients who underwent endarterectomy (i) higher reported PA, (ii) intensity of PA and (iii) lower reported SB were associated with lower prevalence of intraplaque haemorrhage. This could be a mechanism whereby PA protects against cerebrovascular disease (stroke) and death. PMID: 30842104 [PubMed - as supplied by publisher]
Source: British Journal of Sports Medicine - March 5, 2019 Category: Sports Medicine Authors: Mury P, Mura M, Della-Schiava N, Chanon S, Vieille-Marchiset A, Nicaise V, Chirico EN, Collet-Benzaquen D, Lermusiaux P, Connes P, Millon A, Pialoux V Tags: Br J Sports Med Source Type: research

Meta-analysis of the procedural risks of carotid endarterectomy and carotid artery stenting over time.
CONCLUSIONS: Risks of procedural stroke/death following CEA appear to have decreased substantially. There was no evidence of a change in stroke/death rates following CAS. PMID: 29205297 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - December 4, 2017 Category: Surgery Authors: Lokuge K, de Waard DD, Halliday A, Gray A, Bulbulia R, Mihaylova B Tags: Br J Surg Source Type: research

Meta ‐analysis of the procedural risks of carotid endarterectomy and carotid artery stenting over time
ConclusionsRisks of procedural stroke/death following CEA appear to have decreased substantially. There was no evidence of a change in stroke/death rates following CAS.
Source: British Journal of Surgery - December 1, 2017 Category: Surgery Authors: K. Lokuge, D. D. de Waard, A. Halliday, A. Gray, R. Bulbulia, B. Mihaylova Tags: Systematic review Source Type: research

Meta-analysis of the costs of carotid artery stenting and carotid endarterectomy.
CONCLUSION: Hospitalization and long-term costs of CAS and CEA appear similar. Economic considerations should not influence the choice of stenting or surgery in patients with carotid artery stenosis being considered for revascularization. PMID: 28783225 [PubMed - in process]
Source: The British Journal of Surgery - August 9, 2017 Category: Surgery Authors: de Vries EE, Baldew VGM, den Ruijter HM, de Borst GJ Tags: Br J Surg Source Type: research

Meta ‐analysis of the costs of carotid artery stenting and carotid endarterectomy
ConclusionHospitalization and long‐term costs of CAS and CEA appear similar. Economic considerations should not influence the choice of stenting or surgery in patients with carotid artery stenosis being considered for revascularization.
Source: British Journal of Surgery - August 7, 2017 Category: Surgery Authors: E. E. de Vries, V. G. M. Baldew, H. M. den Ruijter, G. J. de Borst Tags: Systematic review Source Type: research