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Carotid interposition in patients with head and neck tumors: clinical experience of 13 cases reconstructed with a great saphenous vein autograft
CONCLUSION AND SIGNIFICANCE: CIG in HNC setting can achieve oncologic-control with an acceptable rate of complications. Routine shunting, heparinization, and elevating blood-pressure during closure seem to be safe protocols to maintain cerebral-circulation perioperatively. A moderate graft-blowout risk should be considered.PMID:35499961 | DOI:10.1080/00016489.2022.2067356
Source: Acta Oto-Laryngologica - May 2, 2022 Category: ENT & OMF Authors: Sherif Abolfotouh Leif B äck Katri Aro Patrik Lassus Jyrki Vuola Karri Mesim äki Tommy Wilkman Pirkka Vikatmaa Source Type: research

Molecules, Vol. 26, Pages 3208: Progress in PET Imaging of Neuroinflammation Targeting COX-2 Enzyme
hn Mann Neuroinflammation and cyclooxygenase-2 (COX-2) upregulation are associated with the pathogenesis of degenerative brain diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), epilepsy, and a response to traumatic brain injury (TBI) or stroke. COX-2 is also induced in acute pain, depression, schizophrenia, various cancers, arthritis and in acute allograft rejection. Positron emission tomography (PET) imaging allows for the direct measurement of in vivo COX-2 upregulation and thereby enables disease staging, therapy evaluation and aid quantifying target occupa...
Source: Molecules - May 27, 2021 Category: Chemistry Authors: Jaya Prabhakaran Andrei Molotkov Akiva Mintz J. John Mann Tags: Review Source Type: research

Transplant Radical Nephrectomy and Transplant Radical Nephroureterectomy for Renal Cancer: Postoperative and Survival Outcomes.
CONCLUSIONS This study reports outcomes of the largest series of transplant radical nephrectomy and nephroureterectomy for malignancies of renal allografts. In the optimized setting, extirpative surgeries appear safe, with favorable long-term oncological and survival outcomes. PMID: 33093437 [PubMed - in process]
Source: Annals of Transplantation - October 23, 2020 Category: Transplant Surgery Authors: Nabavizadeh R, Noorali AA, Makhani SS, Hong G, Holzman S, Patil DH, Kim FY, Tso PL, Turgeon NA, Ogan K, Master VA Tags: Ann Transplant Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Heart Transplant Outcomes in Patients With Pretransplant Diabetes Mellitus.
CONCLUSIONS: Heart transplant recipients with pretransplant diabetes fared just as well as patients without pretransplant diabetes in 7 of the 8 outcomes examined, except for the number of days hospitalized during the first 3 years after heart transplant. This study provides clinically important new information on the greater hospitalization time and the reasons for hospitalization during the first 3 years after heart transplant in patients with pretransplant diabetes. PMID: 29092871 [PubMed - in process]
Source: American Journal of Critical Care - November 1, 2017 Category: Nursing Authors: Jalowiec A, Grady KL, White-Williams C Tags: Am J Crit Care Source Type: research

Mortality, rehospitalization, and post-transplant complications in gender-mismatched heart transplant recipients
Conclusion Female HT recipients with male donors had worse 3-year outcomes as compared to male-mismatch and no-mismatch groups.
Source: Heart and Lung: The Journal of Acute and Critical Care - May 10, 2017 Category: Respiratory Medicine Source Type: research

Do outcomes after kidney transplantation differ for black patients in England versus New York State? A comparative, population-cohort analysis
Conclusions Outcomes after kidney transplantation for black patients may not be translatable between countries.
Source: BMJ Open - May 9, 2017 Category: General Medicine Authors: Tahir, S., Gillott, H., Jackson-Spence, F., Nath, J., Mytton, J., Evison, F., Sharif, A. Tags: Open access, Renal medicine Research Source Type: research

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