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Will unpredictable side effects dim the promise of new Alzheimer ’s drugs?
A sea change is underway in the treatment of Alzheimer’s disease, where for the first time a drug that targets the disease’s pathology and clearly slows cognitive decline has hit the U.S. market. A related therapy will likely be approved in the coming months. As many neurologists, patients, and brain scientists celebrate, they’re also nervously eyeing complications from treatment: brain swelling and bleeding, which in clinical trials affected up to about one-third of patients and ranged from asymptomatic to fatal. The side effect—amyloid-related imaging abnormalities, or ARIA—remains mysterious. “We don’...
Source: Science of Aging Knowledge Environment - August 2, 2023 Category: Geriatrics Source Type: research

Structural racism and racial health disparities at the state level: A latent variable approach
Conclusions This research provides further evidence that structural racism is a fundamental cause of racial health disparities and that to repair these inequities, macro-level changes in societal structures, institutions, resource allocation, representation, and power will be necessary.PMID:37500328 | DOI:10.1016/j.jnma.2023.07.003
Source: Journal of the National Medical Association - July 27, 2023 Category: General Medicine Authors: Michael Siegel Madeline Rieders Hannah Rieders Jinan Moumneh Julia Asfour Jinseo Oh Seungjin Oh Source Type: research

Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

Arterial Atherosclerosis: Vascular Surgery Interventions
Am Fam Physician. 2022 Jan 1;105(1):65-72.ABSTRACTAtherosclerotic vascular disease is a leading cause of death worldwide. Atherosclerotic stenosis of the internal carotid or intracranial arteries causes up to 15% of strokes. Peripheral artery disease affects up to one in five people in the United States who are 60 years and older and nearly one-half of those who are 85 years and older. Renal artery stenosis may affect up to 5% of people with isolated hypertension and up to 40% of people with other atherosclerotic diseases. All patients with atherosclerotic vascular disease should receive a comprehensive program of guidelin...
Source: Atherosclerosis - January 14, 2022 Category: Cardiology Authors: Jonathon M Firnhaber C S Powell Source Type: research

YouTube as a Source of Information for Transcranial Magnetic Stimulation in Stroke: A Quality, Reliability and Accuracy Analysis
Stroke is one of the major causes of death and disability among adults and affects more than 795000 people each year in the United States.1,2 Globally, 6.5 million stroke deaths occurred in 2013 and stroke was the 2nd most common cause of mortality worldwide.2,3 Usually, after a stroke, the damaged brain region and surrounding healthy cells try to repair the disrupted neural networks and to regulate the disrupted functions by creating new networks. However, the complete recovery of motor functions takes place in only 20% of patients, depending on the location of the damaged area, its size, and the general health of the patient.
Source: Journal of Stroke and Cerebrovascular Diseases - September 21, 2020 Category: Neurology Authors: Ayhan Askin, lker Sengul, Aliye Tosun Source Type: research

Type A aortic dissection in the East and West: A comparative study between two hospitals from China and the US
ConclusionsThere was a significant increase in the number of ATAAD at NDTH during the study period while the number at MGH remained stable. Hypertension was a common major risk factor; however, the onset of ATAAD at NDTH was nearly one decade earlier than MGH. Chinese patients tended to have more complicated preoperative pathophysiology at presentation and underwent more extensive surgical repair.
Source: Journal of Cardiac Surgery - August 20, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Andrea L. Axtell, Yunxing Xue, Jason Z. Qu, Qing Zhou, Jun Pan, Hailong Cao, Tuo Pan, Arminder S. Jassar, Dongjin Wang, Thoralf M. Sundt, Duke E. Cameron Tags: ORIGINAL ARTICLE Source Type: research

Cannabis Use Disorder and Perioperative Outcomes in Major Elective Surgeries A Retrospective Cohort Analysis
Conclusions An active cannabis use disorder is associated with an increased perioperative risk of myocardial infarction.Editor ’s PerspectiveWhat We Already Know about This TopicCannabis is known to have cardiovascular and psychoactive effectsThe association between active cannabis use disorder and postoperative outcomes remains unclearWhat This Article Tells Us That Is NewIn the United States, administrative data demonstrate that cannabis use disorder has increased in prevalence from 2010 to 2015Active cannabis use disorder is not associated with a change in overall perioperative morbidity, mortality, length of stay, or...
Source: Anesthesiology - March 10, 2020 Category: Anesthesiology Source Type: research

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