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Impaired Cerebral Autoregulation After Subarachnoid Hemorrhage: A Quantitative Assessment Using a Mouse Model
In this study, we quantitatively examined the impact of SAH on cerebral autoregulation using a mouse endovascular perforation model and a newly developed approach combining absolute and relative CBF measurements. This method enables a direct quantitative comparison of cerebral autoregulation between individual animals (e.g., SAH vs. control or sham-operated mice), which cannot be done solely using relative CBF changes by laser Doppler flowmetry. Here, absolute CBF was measured via injection of fluorescent microspheres at a baseline BP. In separate groups of animals, in vivo laser Doppler flowmetry was used to measure relat...
Source: Frontiers in Physiology - June 8, 2021 Category: Physiology Source Type: research

A Noninvasive Stroke Volume Monitoring for Early Detection of Minimal Blood Loss: A Pilot Study
Conclusion: Continuous noninvasive monitoring of SV may be superior to conventional indices (e.g., heart rate, blood pressure, or shock index) for early identification of acute blood loss. As an operator-independent and point-of-care technology, the SV whole body bio-impedance measurement may assist in accurate monitoring of potentially bleeding patients and early identification of hemorrhage.
Source: Shock - January 16, 2021 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Platelet count and mean volume in acute stroke: a systematic review and meta-analysis.
Authors: Sadeghi F, Kovács S, Zsóri KS, Csiki Z, Bereczky Z, Shemirani AH Abstract Changes of mean platelet volume (MPV) and platelet count (PC) could be a marker or a predictor of acute stroke (AS). We conducted a systematic review and meta-analysis of the published literature on the reporting of MPV and PC in AS. Studies were included in accordance with Patient Population or Problem, Intervention, Comparison, Outcomes, and Setting framework. The PRISMA strategy was used to report findings. Risk of bias was assessed with the Newcastle-Ottawa Scale. We included 34 eligible articles retrieved from the literature. ...
Source: Platelets - October 30, 2019 Category: Hematology Tags: Platelets Source Type: research

Iron Metabolism and Brain Development in Premature Infants
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Got...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research

Validation of Sickle Cell Disease Severity Score in a Cohort of Hemoglobin SC Disease Patients
Conclusion: Despite having been derived from a SCD population that was 26% HbSC, the study was unable to validate the SSS within the cohort of HbSC patients. This may reflect the differences in patient population and/or therapeutic intervention between this cohort and the CSSCD cohort used in the construction of the SSS calculator. While SSS was found to correlate with 3 discrete markers of disease morbidity (TRJV, CVA, creatinine clearance), it appears that a new scoring system is required to accurately predict clinical mortality and morbidity in contemporary cohorts of adult HbSC disease patients.DisclosuresNo relevant c...
Source: Blood - November 21, 2018 Category: Hematology Authors: Rosart, R. M., Pestrin, O. A., Tomlinson, G. A., Ward, R., Pendergrast, J., Binding, A., Kuo, K. H. M. Tags: 903. Outcomes Research-Non-Malignant Hematology: Poster I Source Type: research

Educational Intervention Reduces Utilization of Low-Value Testing in Cerebrovascular Inpatients: An Example of Rapidly Implementable Quality Improvement (P2.309)
Conclusions: In this prospective quality improvement study, an educational intervention resulted in significant reduction in utilization of low-value tests in patients admitted to an inpatient cerebrovascular service. While the per-patient costs of these diagnostic tests were small, a similar approach at the system level could result in considerable avoidance of low value testing and associated costs, particularly if applied to higher-cost/lower-value investigations and procedures.Disclosure: Dr. Scharf has nothing to disclose. Dr. Jones has nothing to disclose. Dr. Martinez-Thompson has nothing to disclose. Dr. Pichler ha...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Scharf, E., Jones, A., Martinez-Thompson, J., Pichler, M., Cohen, A., Clark, S., Nozile-Firth, K., Jones, L. Tags: Stroke Systems of Care Source Type: research

The Speed and Reliability of Pre-Hospital Point-of-Care Laboratory Testing on the Mobile Stroke Treatment Unit (P4.314)
Conclusion: Critical laboratory tests can be performed rapidly and successfully in a MSTU to assist in early pre-hospital ischemic stroke thrombolysis or warfarin reversal in ICH.Disclosure: Dr. Organek has nothing to disclose. Dr. Taqui has nothing to disclose. Dr. Cerejo has nothing to disclose. Dr. Itrat has nothing to disclose. Dr. Buletko has nothing to disclose. Dr. Cho has nothing to disclose. Dr. Sheikhi has nothing to disclose. Dr. Winners has nothing to disclose. Dr. Rasmussen has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Uchino has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Organek, N., Taqui, A., Cerejo, R., Itrat, A., Buletko, A., Cho, S., Sheikhi, L., Winners, S., Rasmussen, P., Hussain, M., Uchino, K. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke, Prehospital, and Telemedicine Source Type: research

Haemodilution for acute ischaemic stroke.
CONCLUSIONS: The overall results of this review showed no clear evidence of benefit of haemodilution therapy for acute ischaemic stroke.These results are compatible with no persuasive beneficial evidence of haemodilution therapy for acute ischaemic stroke. This therapy has not been proven to improve survival or functional outcome. PMID: 25159027 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 27, 2014 Category: Journals (General) Authors: Chang TS, Jensen MB Tags: Cochrane Database Syst Rev Source Type: research