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Oxidative Stress Biomarkers of Brain Damage Clinical Sciences
Conclusions—Elevated hyperacute plasma F2-isoP concentrations independently predict the occurrence of IG and IG volume in patients with acute ischemic stroke. If validated in future studies, measuring plasma F2-isoP might be helpful in the acute setting to stratify patients with acute ischemic stroke for relative severity of ischemic injury and expected progression.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Svetlana Lorenzano, Natalia S. Rost, Muhib Khan, Hua Li, Fabricio O. Lima, Matthew B. Maas, Rebecca E. Green, Tijy K. Thankachan, Allison J. Dipietro, Ken Arai, Angel T. Som, Loc-Duyen D. Pham, Ona Wu, Gordon J. Harris, Eng H. Lo, Jeffrey B. Blumberg, Pau Tags: Ischemic Stroke Original Contributions Source Type: research

Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial
AbstractMesenchymal stromal cells (MSCs) can differentiate into multiple tissues. Preclinical studies have shown that MSC-based therapy is a potential new treatment approach for ischemic stroke. These results support the urgent need for further studies of MSC transplantation in the treatment of ischemic stroke in humans. Here, we develop a prospective, randomized, controlled, observer-blinded phase II trial to assess the clinical safety, feasibility, and therapeutic mechanisms of allogenic bone marrow-derived MSCs (BM-MSCs) by intrathecal infusion in the treatment of patients with cerebral infarction within the middle cere...
Source: Translational Stroke Research - May 23, 2018 Category: Neurology Source Type: research

Early Magnetic Resonance Imaging Decreases Hospital Length of Stay in Patients with Ischemic Stroke
Imaging modalities are important part of stroke evaluation. Noncontrast head computed tomography (CT) is the initial imaging modality in acute stroke and although important to rule out acute hemorrhage and making a decision on thrombolytic treatment, ischemic changes may not be visible on CT for up to 24 hours. Magnetic resonance imaging (MRI) brain is an invaluable tool to confirm an ischemic stroke and facilitates stroke evaluation. Objective of this study was to investigate the correlation between time to MRI and length of hospital stay.
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Bharti Manwani, Subhendu Rath, Nora S. Lee, Ilene Staff, Christoph Stretz, Janhavi Modak, Pasquale F. Finelli Source Type: research

Criteria for Emergency Brain MRI During Stroke-Alert
Intravenous (IV) tissue plasminogen activator (tPA) should be given to patients with acute ischemic stroke (AIS) and avoided in stroke mimics (SM). Select use of emergency brain magnetic resonance imaging (eMRI-brain) in stroke-alerts aids diagnosis, but accepted utilization criteria for eMRI-brain do not currently exist. We developed criteria for eMRI-brain and report the yield of eMRI-brain in stroke-alert patients.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2021 Category: Neurology Authors: Evgeny Sidorov, Courtney Iser, Nidhi Kapoor, Bappaditya Ray, Juliane Chainakul, Chao Xu, Andrei V. Alexandrov, David Lee Gordon Source Type: research

Interobserver Agreement of ASPECT Score Distribution for Noncontrast CT, CT Angiography, and CT Perfusion in Acute Stroke Brief Reports
Conclusions— CTP-CBV demonstrates the highest interobserver agreement for individual ASPECTS regions.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Finlayson, O., John, V., Yeung, R., Dowlatshahi, D., Howard, P., Zhang, L., Swartz, R., Aviv, R. I. Tags: Acute Cerebral Infarction, Angiography, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Diversity of Stroke Presentation in CADASIL: Study from Patients Harboring the Predominant NOTCH3 Mutation R544C
This study investigated the clinical stroke presentation and cranial magnetic resonance imaging (MRI) findings in a group of patients with CADASIL. We reviewed the clinical stroke presentation and brain MRI findings in 73 consecutive Korean patients aged>18 years diagnosed with CADASIL between May 2004 and April 2009. Brain MRI images were also scored for lacunar infarction and cerebral microbleeds. Intracranial atherosclerosis (ICAS) was assessed by magnetic resonance angiography. Disability was measured with the modified Rankin scale (mRS) and classified as good (mRS score 0-2) or poor (mRS score 3-5). In this study, 65 ...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2011 Category: Neurology Authors: Jay Chol Choi, Sook-Keun Song, Jung Seok Lee, Sa-Yoon Kang, Ji-Hoon Kang Tags: Original Articles Source Type: research

Action-Observation In Stroke Rehabilitation
A new study finds that stroke patients' brains show strong cortical motor activity when observing others performing physical tasks - a finding that offers new insight into stroke rehabilitation. Using functional magnetic resonance imaging (fMRI), a team of researchers from USC monitored the brains of 24 individuals - 12 who had suffered strokes and 12 age-matched people who had not - as they watched others performing actions made using the arm and hand that would be difficult for a person who can no longer use their arm due to stroke - actions like lifting a pencil or flipping a card...
Source: Health News from Medical News Today - June 13, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Decreased Corticospinal Tract Fractional Anisotropy Predicts Long-term Motor Outcome After Stroke Brief Reports
Conclusions— rFA at day 30 is an independent predictor of long-term motor outcome after stroke.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Puig, J., Blasco, G., Daunis-I-Estadella, J., Thomalla, G., Castellanos, M., Figueras, J., Remollo, S., van Eendenburg, C., Sanchez-Gonzalez, J., Serena, J., Pedraza, S. Tags: CT and MRI, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Timing-Invariant Imaging of Collateral Vessels in Acute Ischemic Stroke Clinical Sciences
Conclusions— Collateral vessels may not always be visible on standard single time-frame CTA because of delayed contrast arrival. Future prognostic studies in acute stroke should consider delay-insensitive techniques, such as TI-CTA, instead of standard single time-frame imaging, such as standard CTA.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Smit, E. J., Vonken, E.-j., van Seeters, T., Dankbaar, J. W., van der Schaaf, I. C., Kappelle, L. J., van Ginneken, B., Velthuis, B. K., Prokop, M. Tags: Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Phase I Study of Intravenous Low-dose Granulocyte Colony-stimulating Factor in Acute and Subacute Ischemic Stroke
We examined the safety and tolerability of low-dose G-CSF and investigated the effectiveness of G-CSF given intravenously in the acute phase (at 24 hours) or subacute phase (at 7 days) of ischemic stroke.Methods: Three intravenous dose regimens (150, 300, or 450 μg/body/day, divided into 2 doses for 5 days) of G-CSF were examined in 18 patients with magnetic resonance imaging (MRI)–confirmed infarct in the territory of the middle cerebral artery. Nine patients received the first dose at 24 hours poststroke (acute group) and 9 patients received the first dose on day 7 poststroke (subacute group; n = 3 at each dose in ea...
Source: Journal of Stroke and Cerebrovascular Diseases - September 10, 2012 Category: Neurology Authors: Yusuke Moriya, Atsushi Mizuma, Tsuyoshi Uesugi, Yoichi Ohnuki, Eiichiro Nagata, Wakoh Takahashi, Hiroyuki Kobayashi, Hiroshi Kawada, Kiyoshi Ando, Shigeharu Takagi, Shunya Takizawa Tags: Original Articles Source Type: research

Admission Insular Infarction >25% Is the Strongest Predictor of Large Mismatch Loss in Proximal Middle Cerebral Artery Stroke Clinical Sciences
Conclusions— Admission insular infarction >25% is the strongest predictor of large mismatch loss in this cohort of proximal middle cerebral artery occlusive stroke. This outcome marker may help to identify treatment-eligible patients who are in greatest need of rapid reperfusion therapy.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Kamalian, S., Kemmling, A., Borgie, R. C., Morais, L. T., Payabvash, S., Franceschi, A. M., Kamalian, S., Yoo, A. J., Furie, K. L., Lev, M. H. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Arterial Spin Labeling Versus Bolus-Tracking Perfusion in Hyperacute Stroke Clinical Sciences
Conclusions— ASL-DWI mismatch shows potential to identify salvageable tissue in hyperacute stroke.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Bivard, A., Krishnamurthy, V., Stanwell, P., Levi, C., Spratt, N. J., Davis, S., Parsons, M. Tags: CT and MRI Clinical Sciences Source Type: research

Impact of Window Setting Optimization on Accuracy of Computed Tomography and Computed Tomography Angiography Source Image-based Alberta Stroke Program Early Computed Tomography Score
This study analyzed the effect of optimization of window settings on the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) performed on noncontrast CT (NCCT) and CT angiography source images (CTA-SI). ASPECTS was calculated on NCCT and CTA-SI with standard and optimized window width/center settings in a consecutive series of patients with acute ishcemic stroke. The difference between CT-based ASPECTS and ASPECTS performed on follow-up magnetic resonance imaging (MRI) were calculated to determine the disparity between initial estimates of the extent of ischemia on CT and follow-up lesion imaging b...
Source: Journal of Stroke and Cerebrovascular Diseases - June 29, 2012 Category: Neurology Authors: Ethem Murat Arsava, Jukka T. Saarinen, Ali Unal, Erhan Akpinar, Kader K. Oguz, Mehmet Akif Topcuoglu Tags: Original Articles Source Type: research

Iodinated Contrast Does Not Alter Clotting Dynamics in Acute Ischemic Stroke as Measured by Thromboelastography Clinical Sciences
Conclusions— Our data do not support an effect of iodinated contrast agents on clot formation or tPA activity.
Source: Stroke - January 27, 2014 Category: Neurology Authors: McDonald, M. M., Archeval-Lao, J. M., Cai, C., Peng, H., Sangha, N., Parker, S. A., Wetzel, J., Riney, S. A., Cherches, M. F., Guthrie, G. J., Roper, T. C., Kawano-Castillo, J. F., Pandurengan, R., Rahbar, M. H., Grotta, J. C. Tags: Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Increasing Use of Computed Tomographic Perfusion and Computed Tomographic Angiograms in Acute Ischemic Stroke From 2006 to 2010 Clinical Sciences
Conclusions— There was a marked increase in the rate of CTA and CTP studies in setting of acute ischemic stroke from 2006 to 2010, and both modalities were associated with increased reperfusion therapy use.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Vagal, A., Meganathan, K., Kleindorfer, D. O., Adeoye, O., Hornung, R., Khatri, P. Tags: Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research