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Prediction of Poststroke Hemorrhagic Transformation Using Computed Tomography Perfusion Clinical Sciences
Conclusions— Tmax >14 s was the CTP parameter most strongly associated with PH. This outperformed relative cerebral blood flow <30%, which closely equates to CTP estimates of ischemic core volume. Although ischemic core volume on CTP is useful in the pretreatment prediction of PH, severe hypoperfusion on Tmax is more strongly associated and may allow better prediction of the likely anatomic location of hemorrhage.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Yassi, N., Parsons, M. W., Christensen, S., Sharma, G., Bivard, A., Donnan, G. A., Levi, C. R., Desmond, P. M., Davis, S. M., Campbell, B. C. V. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Clopidogrel Use Is Associated With an Increased Prevalence of Cerebral Microbleeds in a Stroke-Free Population: The Rotterdam Study Stroke
Conclusions In stroke-free individuals, clopidogrel use was associated with a higher prevalence and higher number of CMBs. Whether this association is causal requires confirmation in prospective studies, especially given the small number of participants taking clopidogrel and the possibility of residual confounding in this study.
Source: JAHA:Journal of the American Heart Association - September 26, 2013 Category: Cardiology Authors: Darweesh, S. K. L., Leening, M. J. G., Akoudad, S., Loth, D. W., Hofman, A., Arfan Ikram, M., Vernooij, M. W., Stricker, B. H. Tags: Stroke Source Type: research

Cerebral Microbleeds on T2*-Weighted Images and Hemorrhagic Transformation after Antithrombotic Therapies for Ischemic Stroke
In conclusion, the severity of neurological deficits and the ASPECTS-DWI are closely correlated to the development of HT related to anticoagulants/antiplatelets but not to CMBs on T2*-weighted images.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Wakoh Takahashi, Yusuke Moriya, Atsushi Mizuma, Tsuyoshi Uesugi, Yoichi Ohnuki, Shunya Takizawa Tags: Original Articles Source Type: research

Alberta Stroke Program Early Computed Tomography Score to Select Patients for Endovascular Treatment: Interventional Management of Stroke (IMS)-III Trial Clinical Sciences
Conclusions— ASPECTS is a strong predictor of outcome and a predictor of reperfusion. ASPECTS did not identify a subpopulation of subjects that particularly benefitted from endovascular therapy immediately after routine intravenous tPA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00359424.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Hill, M. D., Demchuk, A. M., Goyal, M., Jovin, T. G., Foster, L. D., Tomsick, T. A., von Kummer, R., Yeatts, S. D., Palesch, Y. Y., Broderick, J. P., for the IMS3 Investigators Tags: Angiography, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis, Angioplasty and Stenting Clinical Sciences Source Type: research

Six-Minute Magnetic Resonance Imaging Protocol for Evaluation of Acute Ischemic Stroke: Pushing the Boundaries Clinical Sciences
Conclusions— A 6-minute multimodal MR protocol with good diagnostic quality is feasible for the evaluation of patients with acute ischemic stroke and can result in significant reduction in scan time rivaling that of the multimodal computed tomographic protocol.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Nael, K., Khan, R., Choudhary, G., Meshksar, A., Villablanca, P., Tay, J., Drake, K., Coull, B. M., Kidwell, C. S. Tags: CT and MRI, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Atrial Fibrillation and Cognitive Decline-The Role of Subclinical Cerebral Infarcts: The Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— The association of incident AF with cognitive decline in stroke-free individuals can be explained by the presence or development of SCIs, raising the possibility of anticoagulation as a strategy to prevent cognitive decline in AF.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Chen, L. Y., Lopez, F. L., Gottesman, R. F., Huxley, R. R., Agarwal, S. K., Loehr, L., Mosley, T., Alonso, A. Tags: Cerebrovascular disease/stroke, Arrhythmias, clinical electrophysiology, drugs, Computerized tomography and Magnetic Resonance Imaging, Epidemiology Clinical Sciences Source Type: research

Cervical Arterial Dissections and Association With Cervical Manipulative Therapy: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Conclusions— CD is an important cause of ischemic stroke in young and middle-aged patients. CD is most prevalent in the upper cervical spine and can involve the internal carotid artery or vertebral artery. Although current biomechanical evidence is insufficient to establish the claim that CMT causes CD, clinical reports suggest that mechanical forces play a role in a considerable number of CDs and most population controlled studies have found an association between CMT and VAD stroke in young patients. Although the incidence of CMT-associated CD in patients who have previously received CMT is not well established, an...
Source: Stroke - September 22, 2014 Category: Neurology Authors: Biller, J., Sacco, R. L., Albuquerque, F. C., Demaerschalk, B. M., Fayad, P., Long, P. H., Noorollah, L. D., Panagos, P. D., Schievink, W. I., Schwartz, N. E., Shuaib, A., Thaler, D. E., Tirschwell, D. L., on behalf of the American Heart Association Strok Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Determinants of White Matter Hyperintensity Burden Differ at the Extremes of Ages of Ischemic Stroke Onset
Age is a well-known risk factor for both stroke and increased burden of white matter hyperintensity (WMH), as detected on magnetic resonance imaging (MRI) scans. However, in patients diagnosed with ischemic stroke (IS), WMH volume (WMHv) varies significantly across age groups. We sought to examine the determinants of WMH burden across the ages of stroke onset with the goal to uncover potential age-specific stroke prevention targets.
Source: Journal of Stroke and Cerebrovascular Diseases - January 6, 2015 Category: Neurology Authors: Cathy R. Zhang, Lisa Cloonan, Kaitlin M. Fitzpatrick, Allison S. Kanakis, Alison M. Ayres, Karen L. Furie, Jonathan Rosand, Natalia S. Rost Source Type: research

Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke Clinical Sciences
Conclusions— Dependent on blood–brain barrier integrity before an acute ischemic brain injury, preexisting NMDAR1 autoantibodies seem to be beneficial or detrimental.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Zerche, M., Weissenborn, K., Ott, C., Dere, E., Asif, A. R., Worthmann, H., Hassouna, I., Rentzsch, K., Tryc, A. B., Dahm, L., Steiner, J., Binder, L., Wiltfang, J., Siren, A.-L., Stocker, W., Ehrenreich, H. Tags: CT and MRI, Acute Cerebral Infarction Clinical Sciences Source Type: research

Brain Magnetic Resonance Imaging Findings Fail to Suspect Fabry Disease in Young Patients With an Acute Cerebrovascular Event Clinical Sciences
Conclusions— Brain MRI findings cannot serve to suspect FD in young patients presenting with an acute cerebrovascular event. This deserves consideration in the search for possible causes of young patients with stroke. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00414583.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Fazekas, F., Enzinger, C., Schmidt, R., Grittner, U., Giese, A.-K., Hennerici, M. G., Huber, R., Jungehulsing, G. J., Kaps, M., Kessler, C., Martus, P., Putaala, J., Ropele, S., Tanislav, C., Tatlisumak, T., Thijs, V., von Sarnowski, B., Norrving, B., Rol Tags: CT and MRI, Genetics of Stroke, Stroke in Children and the Young Clinical Sciences Source Type: research

Sulcal Effacement With Preserved Gray-White Junction: A Sign of Reversible Ischemia Brief Reports
Conclusions— Sulcal effacement with preserved gray–white delineation is occasionally visualized in patients with proximal occlusion strokes, relates to robust leptomeningeal collaterals, and indicates preserved underlying parenchyma. ISE should not be used to exclude patients from thrombectomy.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Haussen, D. C., Lima, A., Frankel, M., Anderson, A., Belagaje, S., Nahab, F., Rangaraju, S., Nogueira, R. G. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Angiography, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Relationship Between Lesion Topology and Clinical Outcome in Anterior Circulation Large Vessel Occlusions Clinical Sciences
Conclusions— Involvement of the right parieto-occipital (M6) and left superior frontal (M4) regions affect clinical outcome in anterior large vessel occlusions over and above the effect of infarct volume and should be considered during prognostication.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Rangaraju, S., Streib, C., Aghaebrahim, A., Jadhav, A., Frankel, M., Jovin, T. G. Tags: Embolic stroke, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research

Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke Clinical Sciences
Conclusions— Leukoaraiosis significantly modulates the association between infarct volume and NIHSS. The clinical implications of these findings need further exploration in prospective studies but may be relevant to mitigate outcome differences in patients with stroke by aiding treatment decisions that rely on the NIHSS.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Helenius, J., Henninger, N. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Transient Ischemic Attack Fast-track and Long-Term Stroke Risk: Role of Diffusion-Weighted Magnetic Resonance Imaging
In this study, we evaluated the role of positive DWI lesions and vascular risk factors on stroke, cardiovascular death, and mortality at 90 days (T0), 1 year (T1), and 5 years (T2). Moreover, we also evaluated the association between stroke risk and the presence of DWI lesions.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2015 Category: Neurology Authors: Sabrina Anticoli, Francesca Romana Pezzella, Claudio Pozzessere, Luca Gallelli, Maria Cristina Bravi, Valeria Caso, Antonio Siniscalchi Source Type: research

Connectivity measures are robust biomarkers of cortical function and plasticity after stroke
This study examined specific electroencephalography cortical connectivity measures as biomarkers by assessing their relationship with motor deficits across 28 days of intensive therapy. Resting-state connectivity measures were acquired four times using dense array (256 leads) electroencephalography in 12 hemiparetic patients (7.3 ± 4.0 months post-stroke, age 26–75 years, six male/six female) across 28 days of intensive therapy targeting arm motor deficits. Structural magnetic resonance imaging measured corticospinal tract injury and infarct volume. At baseline, connectivity with leads overlying ipsilesional p...
Source: Brain - July 23, 2015 Category: Neurology Authors: Wu, J., Quinlan, E. B., Dodakian, L., McKenzie, A., Kathuria, N., Zhou, R. J., Augsburger, R., See, J., Le, V. H., Srinivasan, R., Cramer, S. C. Tags: CNS Injury and Stroke Original Articles Source Type: research