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IL-1 β is not critical to chronic heart dysfunction in mice with Chagas disease
In conclusion, the absence of functional IL-1β/IL-1R signaling did not prevent or reverse the decrease of SV or the incidence of cardiac arrhythmias induced by chronic T. cruzi infection, implying this is not a critical mechanism in generating or maintaining CCC. Since similar cardiac abnormalities were previously credited to IL-1β signaling, ruling out this mechanism is important to discourage further attempts of IL-1β blockade as a therapeutical measure.
Source: Frontiers in Immunology - October 14, 2022 Category: Allergy & Immunology Source Type: research

Chagas heart disease: An overview of diagnosis, manifestations, treatment, and care
We describe the clinical manifestations, diagnosis and classification criteria, risk stratification, and approach to the different clinical aspects of CHD using diagnostic tools and pharmacological and non-pharmacological treatments.PMID:35070110 | PMC:PMC8716970 | DOI:10.4330/wjc.v13.i12.654
Source: World Journal of Cardiology - January 24, 2022 Category: Cardiology Authors: Roberto M Saraiva Mauro Felippe F Mediano Fernanda Sns Mendes Gilberto Marcelo Sperandio da Silva Henrique H Veloso Luiz Henrique C Sangenis Paula Simpl ício da Silva Flavia Mazzoli-Rocha Andr éa S Sousa Marcelo T Holanda Alejandro M Hasslocher-Moreno Source Type: research

Multiple Strokes in a Latin American Patient
We present a case of a recent immigrant from El Salvador without past medical history who presented to our hospital with symptoms concerning for acute stroke. Brain magnetic resonance imaging (MRI) with gadolinium confirmed an acute stroke along with multiple prior infarcts involving different vascular beds. Head magnetic resonance arteriogram did not reveal any occlusions/stenosis or aneurysmal changes. His subsequent extensive evaluation included an electrocardiogram (ECG) that revealed bifascicular block and echocardiography that suggested an apical aneurysm, but images were limited to assess. To further assess the like...
Source: Case Reports in Neurology - July 8, 2021 Category: Neurology Source Type: research

Role of FAK signaling in chagasic cardiac hypertrophy.
Abstract Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, and sudden death related to disease progression. Thus, understanding the signaling pathways involved in the chagasic cardiac hypertrophy may provide potential targets for pharmacological therapy. Herein, we investigated the implication of focal adhesion kinase (FAK) signaling pathway in triggering hypertrophic phenotype during acute and chronic T. cruzi infection. C57BL/6 mice infected with T. cruzi (Brazil strain) were evaluated for electrocardiographic (ECG) changes, plasma levels of...
Source: Braz J Infect Dis - September 11, 2020 Category: Infectious Diseases Authors: Tucci AR, Oliveira FOR, Lechuga GC, Oliveira GM, Eleuterio AC, Mesquita LB, Farani PSG, Britto C, Moreira OC, Pereira MCS Tags: Braz J Infect Dis Source Type: research

Case Report: Malignant Ventricular Arrhythmias Mimicking Acute Coronary Syndrome in Chagas Disease.
Abstract Chronic Chagas heart disease has different clinical manifestations including arrhythmias, heart failure, and stroke. Chest pain is one of the most common symptoms and when associated with changes in the electrocardiogram, such as T-wave changes, electrically inactive areas, and segmental wall motion abnormalities, may lead to a misdiagnosis of acute coronary syndrome (ACS). Here, we describe two patients with Chagas heart disease and syncope due to sustained ventricular tachycardia who were misdiagnosed with ACS, and discuss the role of novel imaging modalities in the differential diagnosis and risk strat...
Source: The American Journal of Tropical Medicine and Hygiene - February 9, 2020 Category: Tropical Medicine Authors: Moll-Bernardes RJ, Saraiva RM, Sarmento de Oliveira R, Tavares Pinheiro MV, Camargo GC, Xavier de Brito AS, Altino de Almeida S, Siqueira FPR, de Souza Nogueira Sardinha Mendes F, Barbosa RM, Xavier SS, Rosado de Castro PH, Silvestre de Sousa A Tags: Am J Trop Med Hyg Source Type: research

Electrocardiogram in Chagas disease
Abstract Since the initial descriptions of Chagas cardiomyopathy (ChCM), the electrocardiography has played a key role in patient evaluations. The diagnostic criterion of chronic ChCM is the presence of characteristic electrocardiographic (ECG) abnormalities in seropositive individuals, regardless of the presence of symptoms. However, these ECG abnormalities are rarely specific to ChCM and, particularly among the elderly, can be caused by other simultaneous cardiomyopathies. ECG abnormalities can predict the occurrence of heart failure, stroke, and even death. Nevertheless, most prognostic studies have included Chagas dise...
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 8, 2018 Category: Tropical Medicine Source Type: research