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Therapy: Hormonal Therapy

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Total 218 results found since Jan 2013.

More Evidence That Hormone Therapy Might Not Help Women's Hearts
Review also found raised risk of stroke for some, although timing of use may be a key factor
Source: WebMD Health - March 10, 2015 Category: Consumer Health News Source Type: news

Bioidentical hormones, menopausal women, and the lure of the “natural” in U.S. anti-aging medicine
Publication date: May 2015 Source:Social Science & Medicine, Volume 132 Author(s): Jennifer R. Fishman , Michael A. Flatt , Richard A. Settersten Jr. In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as rates of HRT prescription fell, another hormonal therapy rose in its wake: bioidentical hormone replacement therapy (BHRT). Anti-aging clinicians, the primary prescribers of ...
Source: Social Science and Medicine - March 19, 2015 Category: Psychiatry & Psychology Source Type: research

Menopausal hormone therapy use in 17 European countries during the last decade
Introduction: The first ‘Women's Health Initiative’ (WHI) randomised controlled trial assessed use of continuous combined menopausal hormone therapy (cc-MHT). It was prematurely stopped because of an increased invasive breast cancer (BC), coronary heart disease (CHD), stroke and pulmonary embolism risk. Consequently, scientific societies recommended use of MHT at the lowest effective dose for the shortest duration. As a result, a sharp decline in MHT use occurred worldwide.
Source: Maturitas - April 21, 2015 Category: Primary Care Authors: Lieveke Ameye, Caroline Antoine, Marianne Paesmans, Evandro de Azambuja, Serge Rozenberg Tags: O44 Source Type: research

Associations between postmenopausal hormone therapy and strokes in a National cohort study
The Women Health Initiative randomized clinical studies on effects of two postmenopausal hormone therapies (HT) were stopped prematurely mainly due to stroke risk.
Source: Maturitas - April 21, 2015 Category: Primary Care Authors: Ellen Løkkegaard, Anne K. Nielsen, Øjvind Lidegaard Tags: O28 Source Type: research

Menopausal hormone therapy, depression, headache, vasomotor symptoms and absence from work: results from 3 years follow up in a Dutch gynecology clinic
Introduction: Use of menopausal hormone therapy (MHT) has dropped worldwide during the last decade after the ‘Women's Health Initiative’ (WHI) trial reported increased breast cancer, stroke and embolism risk. Women with bothersome menopausal complaints resorted to complementary and alternative medications with less or unproven efficacy. Even when indicated use of MHT is low and of short duration, possibly affecting individual wellbeing and ability to work.
Source: Maturitas - April 21, 2015 Category: Primary Care Authors: Mojdeh Shayesteh, Ingrid Pinas Tags: O5 Source Type: research

Hormone therapy and venous thromboembolism among postmenopausal women
Despite a decrease in postmenopausal hormone therapy (HT) use during the last decade, many women are still prescribed this treatment which remains the most effective to counteract climacteric symptoms. However, HT increases the risk of breast cancer, stroke and venous thromboembolism (VTE) which represents the major harmful effect of short-term duration use. Nevertheless, this benefit/risk ratio has been established among women using oral estrogens alone or combined with a specific progestogen and cannot be necessary extrapolated to other HT.
Source: Maturitas - April 21, 2015 Category: Primary Care Authors: Marianne Canonico Tags: INV32 Source Type: research

Many Women Unaware of Female-Specific Stroke Symptoms
Pregnancy, migraines and hormone therapy put women at increased risk, researchers say
Source: WebMD Health - May 7, 2015 Category: Consumer Health News Source Type: news

Menopausal Hormone Therapy for the prevention of cardiovascular disease: Evidence-based customization
Boardman et al. provided this March an updated version of their 2013 Cochrane review [1], aiming to assess the effects of menopausal hormone therapy (MHT) for the prevention of cardiovascular disease in postmenopausal women. The authors concluded that treatment with MHT in postmenopausal women, for either primary or secondary prevention of cardiovascular disease, has little, if any, benefit and causes an increase in the risk of stroke and venous thromboembolic events.
Source: Maturitas - May 7, 2015 Category: Primary Care Authors: Dimitrios G. Goulis, Irene Lambrinoudaki Tags: Editorial Source Type: research

Abstract 1341: Endocrine deprivation therapy increases the sensitivity of breast cancer cells to T cell-mediated lysis independently of estrogen receptor or androgen receptor status
Estrogen deprivation therapy has been used as the first line adjuvant hormonal therapy for breast cancer for over 20 years. Tamoxifen, the first drug discovered to inhibit estrogen receptor signaling, is used to treat premenopausal women with estrogen receptor positive tumors. Although tamoxifen can be therapeutic in most women with estrogen receptor positive tumors, some women do not respond and others eventually develop resistance. In addition, tamoxifen has minimal effect on the growth of estrogen receptor negative tumors, including triple negative breast cancer, which has the poorest prognosis. Furthermore, prolonged a...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kwilas, A. R., Ardiani, A., Gameiro, S. R., Hodge, J. W. Tags: Immunology Source Type: research

Prevalence of menopausal symptoms among mid-life women: findings from electronic medical records
Conclusion: Our findings provide recent data on the types of menopausal symptoms experienced by mid-life women prescribed HT. Electronic medical records may be a rich source of data for future studies of menopausal symptoms in this population.
Source: BMC Women's Health - August 13, 2015 Category: OBGYN Authors: Matthew SussmanJeffrey TrocioCraig BestSebastian MirkinAndrew BushmakinRobert YoodMark FriedmanJoseph MenzinMichael Louie Source Type: research

Reprint of “Use of medroxyprogesterone acetate for hormone therapy in postmenopausal women: Is it safe?”
Publication date: Available online 19 August 2015 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Frank Z. Stanczyk, Bhagu R. Bhavnani Medroxyprogesterone acetate (MPA) has been in clinical use for over 30 years, and was generally considered to be safe until the results of long-term studies of postmenopausal hormone therapy (HT) using treatment with conjugated equine estrogens (CEE) combined with MPA and CEE alone suggested that MPA, and perhaps other progestogens, may play a role in the increased risk of breast cancer and cardiovascular diseases. This review examines critically the safety o...
Source: The Journal of Steroid Biochemistry and Molecular Biology - August 21, 2015 Category: Biochemistry Source Type: research

White matter hyperintensities, hot flushes and estrogen - are they related?
Abstract White matter hyperintensities (WMH) are areas of high intensity observed in brain MRI scans. They are usually seen in normal aging but also in a number of neurological and psychiatric disorders. One of the underlying mechanisms is ischemia, expressed as small vessel disease. Since the volume of WMH may correlate with cognition, and an ongoing debate links postmenopausal hormone therapy with stroke and a decline in certain cognitive domains, several MRI studies have addressed this potential association. Two major randomized, placebo-controlled trials - WHIMS and KEEPS, the first including elderly women and...
Source: Climacteric - September 2, 2015 Category: Geriatrics Authors: Pines A Tags: Climacteric Source Type: research

From the 90׳s to now: A brief historical perspective on more than two decades of estrogen neuroprotection.
This article is part of a Special Issue entitled SI:50th Anniversary Issue. PMID: 26740397 [PubMed - as supplied by publisher]
Source: Brain Research - December 29, 2015 Category: Neurology Authors: Engler-Chiurazzi EB, Singh M, Simpkins JW Tags: Brain Res Source Type: research