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Total 334 results found since Jan 2013.

Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke
ConclusionsEstradiol levels correlated with functional outcomes (change in mRS) in both men and women, at least in the acute phase (24  h) of stroke. However, no significant difference in estradiol levels is seen 24 h post-stroke in men or women. Testosterone levels decrease at 24 h after stroke in men. As seen in animal models, aromatase levels increase after acute ischemic stroke, but this was only true for women. These ind icate an active aromatization process in post-menopausal women after acute ischemic stroke.
Source: Biology of Sex Differences - January 7, 2021 Category: Biology Source Type: research

Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study
ConclusionsThese findings suggest that patients (both men and women) with atherothrombotic infarction who have low TC levels would not benefit from receiving statin treatment. Therefore, it is crucial to explore the impact of statin treatment on outcomes in Asian patients, especially Chinese patients with atherothrombotic and low TC levels, in order to improve outcomes after stroke and reduce the disease burden.
Source: Biology of Sex Differences - November 23, 2016 Category: Biology Source Type: research

Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study
ConclusionOur study indicated a significant,non-linear, negative association between plasma selenium and first stroke in males but not in females.Trial registrationChiCTR1800017274.
Source: Biology of Sex Differences - May 29, 2021 Category: Biology Source Type: research

Sex differences in long-term outcomes among acute ischemic stroke patients with diabetes in China
Conclusions These findings suggest that it is crucial to establish the individual scheme of therapy for every patient by different risk factors of stroke, strengthen the rehabilitation of stroke, and carry on the health education early for the secondary prevention of stroke in patients with diabetes mellitus (DM).
Source: Biology of Sex Differences - December 4, 2015 Category: Biology Source Type: research

Circadian preference and stroke characteristics: A descriptive study
This study set out to explore this relationship by examining whether there was an association between circadian preference and stroke characteristics in a sample of stroke outpatients, considering the time of stroke onset, the topography of the stroke and the resulting disability. We also examined whether sleep complaints (snoring, insomnia, sleep apnea) were associated with circadian preferences (i.e., morning-, evening-, and intermediate-types). We also compared circadian preferences and comorbidities in this sample, matched by age and sex, with those of healthy controls who took part in an epidemiological study (EPISONO...
Source: Chronobiology International - January 5, 2022 Category: Biology Authors: Eveli Truksinas Cristina Frange Giuliano da Paz Eliana Lottenberg Vago Monica Levy Andersen Sergio Tufik Fernando Morgadinho Santos Coelho Source Type: research

Circadian rhythms may not influence the outcomes of thrombolysis in patients with ischemic stroke: A study from China.
In conclusion, there was no evidence to predict that circadian rhythms could influence the outcomes of AIS patients treated with rt-PA in China, although stroke onset during nighttime might aggravate neurological impairment before treatment. Further, multicenter and prospective clinical trials with larger number of subjects are still needed to draw more reliable conclusions. PMID: 29993298 [PubMed - as supplied by publisher]
Source: Chronobiology International - July 11, 2018 Category: Biology Authors: Ding J, Bai Z, Zhou D, Li X, Rajah GB, Ding Y, Han J, Ji X, Meng R Tags: Chronobiol Int Source Type: research

Sex differences in the effects of the moon on ischemic stroke incidence: new findings from Beijing, China.
Abstract Stroke is a major cause of death and disability in China, and no therapies have proven effective to prevent it. Popular belief holds that the lunar cycle affects human physiology, behavior, and health. The aim of our study is to determine whether the lunar cycle impacts the incidence of stroke subtypes [intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and ischemic stroke (IS)]. We retrospectively extracted the discharge registry data of all patients with first-ever acute stroke hospitalized in the affiliated hospital of Beijing University of Traditional Chinese Medicine during 2002-2015. Th...
Source: Chronobiology International - July 12, 2020 Category: Biology Authors: Wang RR, Hao Y, Chen J, Wang MQ, Zheng RY, Shi LS, He J Tags: Chronobiol Int Source Type: research

Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats
ConclusionsThese data show that extensive leakiness of the gut barrier is associated with severe post-stroke disability and suggest that reinforcing this barrier may improve stroke outcomes.
Source: Biology of Sex Differences - January 15, 2021 Category: Biology Source Type: research

"MOONSTROKE": Lunar patterns of stroke occurrence combined with circadian and seasonal rhythmicity-A hospital based study.
Abstract Both time of the day and season have been shown to have a significant effect on stroke incidence. In contrast, the role played by the moon has been little studied. We aimed to investigate the potential association of the lunar phase with the incidence of stroke subtypes [intracerebral hemorrhage (ICH), transient ischemic attack (TIA) and ischemic stroke (IS)], adjusted by circadian and seasonal variations. Consecutive stroke admissions to the Royal Melbourne Hospital (RMH) were analyzed from 2004-2011. Of 6252 patients, 4085 (65.3%) had confirmed dates and hour of the day. Of these, 632 (15.5%) had ICH, 6...
Source: Chronobiology International - July 14, 2015 Category: Biology Authors: Mao Y, Schnytzer Y, Busija L, Churilov L, Davis S, Yan B Tags: Chronobiol Int Source Type: research

Serum metabolomic patterns in young patients with ischemic stroke: a case study
ConclusionsSerum metabolomic patterns were significantly different between young patients with ischemic stroke and healthy controls. Our study is beneficial in providing a further view into the pathophysiology of young patients with ischemic stroke.
Source: Metabolomics - February 8, 2021 Category: Biology Source Type: research

Sex differences in the association between diabetes and hypertension and the risk of stroke: cohort of the Tehran Lipid and Glucose Study
ConclusionHypertension and T2D induced higher risk of overall and ischemic stroke in men than women among Iranian population.
Source: Biology of Sex Differences - March 15, 2022 Category: Biology Source Type: research

Sex as predictor for achieved health outcomes and received care in ischemic stroke and intracerebral hemorrhage: a register-based study
ConclusionsA lower proportion of women had good functioning, a difference that remained in IS after adjustments for age, socioeconomic factors, living arrangements, ADL dependency, and stroke severity. The amount of received hospital care was lower for women after adjustments. Whether shorter hospital stay results in lower function or is a consequence of lower function cannot be elucidated. One-year survival was higher in men when no adjustments were made but lower after adjustments. This likely reflects that women were older at time of stroke, had more severe strokes, and more disability pre-stroke —factors that make a ...
Source: Biology of Sex Differences - March 7, 2018 Category: Biology Source Type: research

No association of moon phase with stroke occurrence.
Abstract Stroke occurrence shows strong correlations with sleep disorders and even subtle sleep disturbances have been shown to affect ischemic stroke (IS) occurrence. Chronobiology also exerts effects, like the morning surge in IS occurrence. Lunar cycles have also been shown to affect sleep and other physiological processes, but studies on moon phases and its possible association with occurrence of stroke are rare and nonconclusive. Therefore, we studied the effects of moon phases on stroke hospitalizations and in-hospital mortality nationwide in Finland in 2004-2014. All patients aged ≥18 years with IS or in...
Source: Chronobiology International - May 23, 2018 Category: Biology Authors: Ruuskanen JO, Sipilä JOT, Rautava P, Kytö V Tags: Chronobiol Int Source Type: research

Identification and relative quantification of 3-nitrotyrosine residues in fibrinogen nitrated in vitro and fibrinogen from ischemic stroke patient plasma using LC-MS/MS.
Abstract Ischemic stroke is one of the leading causes of death and disability worldwide. This acute vascular event interferes with blood supply to the brain and induces a burst of free radicals such as nitric oxide and superoxide, producing peroxynitrite, a precursor of strong nitrating agents. Fibrinogen is one of the most abundant plasma proteins; it plays a role in the hemostatic system, mediating clot formation, which can be affected by nitrotyrosine formation. We hypothesized that nitration of fibrinogen by ONOOH and ONOOCO2- radical products could be one of the early events of the ischemic stroke, and protei...
Source: Free Radical Biology and Medicine - February 3, 2021 Category: Biology Authors: Medeiros R, Sousa B, Rossi S, Afonso C, Bonino L, Pitt A, López E, Spickett C, Borthagaray G Tags: Free Radic Biol Med Source Type: research

Down-regulation of MIF by NF{kappa}B under hypoxia accelerated neuronal loss during stroke Research Communications
In this study, we showed that MIF expression is down-regulated by 0.75 ± 0.10-fold of the control in the infarct area in the mouse brains. Two functional cis-acing NFB response elements were identified in the human MIF promoter. Dual activation of hypoxia and NFB signaling resulted in significant reduction of MIF promoter activity to 0.86 ± 0.01-fold of the control. Furthermore, MIF reduced caspase-3 activation and protected neurons from oxidative stress- and in vitro ischemia/reperfusion-induced apoptosis. H2O2 significantly induced cell death with 12.81 ± 0.58-fold increase of TUNEL-positive cells, a...
Source: FASEB Journal - September 30, 2014 Category: Biology Authors: Zhang, S., Zis, O., Ly, P. T. T., Wu, Y., Zhang, S., Zhang, M., Cai, F., Bucala, R., Shyu, W.-C., Song, W. Tags: Research Communications Source Type: research