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Specialty: Hematology
Countries: Nigeria Health
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Total 16 results found since Jan 2013.
Establishing Sickle Cell Disease Stroke Prevention Teams in Africa is Feasible: Program Evaluation Using the RE-AIM Framework
We used the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework to evaluate a Stroke Prevention Team’s readiness to prevent strokes in children with sickle cell anemia living in northern Nigeria. The NIH sponsored Stroke Prevention Trial in Nigeria included a goal of a sustainable stroke prevention program. The program’s 1-year reach for transcranial Doppler screening was 14.7% (4710/32,000) of which 6.0% (281/4710) had abnormal velocities (≥200 cm/s). All participants with abnormal transcranial Doppler velocities were started on hydroxyurea (effectiveness). The leaders of all 5 hospi...
Source: Journal of Pediatric Hematology Oncology - January 1, 2022 Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Variations and characteristics of the various clinical phenotypes in a cohort of Nigerian sickle cell patients
CONCLUSION: The prevalence of SLU, AVN, priapism, nephropathy and the other complications of SCD show some variations from other studies. This variation in the clinical parameters across different clinical phenotypes indicates an interplay between age, genetic and environmental factors.PMID:34493173 | DOI:10.1080/16078454.2021.1972242
Source: Hematology - September 8, 2021 Category: Hematology Authors: Augustine Duru Anazoeze Jude Madu Helen Okoye Charles Nonyelu Onochie Obodo Kelechi Okereke Kenechi Madu Source Type: research
Hemolytic, Vaso-Occlusive and Renal Complications of SCD: Report from the Central Missouri Cohort
ConclusionsThis is the first report describing prevalence of SCD-related complications in the MU-SCD Cohort. We identified this population to have an increasing frequency of hemolytic complications and sickle cell nephropathy with advancing age. Onset of persistent proteinuria occurred in the second decade of life, followed by renal insufficiency or end stage renal disease in subsequent decades. As previously demonstrated in the Cooperative Study of Sickle Cell Disease and the Jamaican SCD Cohort study, renal insufficiency was a significant risk factor for early mortality. Further studies are required for identification of...
Source: Blood - November 21, 2018 Category: Hematology Authors: Nolan, L. W., Yoshida, Y., Coberly, E., Sathi, B. K. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster I Source Type: research
Feasibility trial for primary stroke prevention in children with sickle cell anemia in Nigeria (SPIN trial)
Source: American Journal of Hematology - February 2, 2018 Category: Hematology Authors: Najibah A. Galadanci, Shehu Umar Abdullahi, Leah D. Vance, Abdulkadir Musa Tabari, Shehi Ali, Raymond Belonwu, Auwal Salihu, Aisha Amal Galadanci, Binta Wudil Jibir, Halima Bello ‐Manga, Kathleen Neville, Fenella J. Kirkham, Yu Shyr, Sharon Phillips, Br Tags: ERRATUM Source Type: research
Foetal haemoglobin and disease severity in nigerian children with sickle cell anaemia.
Conclusion: Children with SCA who had moderate disease and those with history of life threatening complications such as stroke and acute chest syndrome had significantly low HbF. Therefore it is recommended that facilities for early quantification of foetal haemoglobin and HbF inducement be made available in order to reduce the morbidity and mortality among these children.
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 25, 2017 Category: Hematology Source Type: research
Pattern of cerebral blood flow velocity using transcranial Doppler ultrasonography in children with sickle cell disorder in Lagos State, Nigeria
Conclusion: The prevalence of abnormal TAMM velocity is high in children with HbSS. The need for availability of and accessibility to transcranial Doppler screening is emphasized.
Source: Mediterranean Journal of Hematology and Infectious Diseases - August 13, 2017 Category: Hematology Source Type: research
