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Specialty: Hematology
Condition: Heart Attack

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Total 519 results found since Jan 2013.

Crosstalk between platelets and the complement system in immune protection and disease.
Abstract Platelets have a central function in repairing vascular damage and stopping acute blood loss. They are equally central to thrombus formation in cardiovascular diseases such as myocardial infarction and ischaemic stroke. Beyond these classical prothrombotic diseases, immune mediated pathologies such as haemolytic uraemic syndrome (HUS) or paroxysmal nocturnal haemoglobinuria (PNH) also feature an increased tendency to form thrombi in various tissues. It has become increasingly clear that the complement system, part of the innate immune system, has an important role in the pathophysiology of these diseases....
Source: Thrombosis and Haemostasis - September 5, 2013 Category: Hematology Authors: Langer H, Verschoor A Tags: Thromb Haemost Source Type: research

Cardiovascular and upper gastrointestinal bleeding consequences of low-dose acetylsalicylic acid discontinuation.
In conclusion, preventing patients with cardiovascular disease from discontinuing ASA could result in substantial clinical and economic gains. PMID: 24008261 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 5, 2013 Category: Hematology Authors: Cea Soriano L, Garcia Rodriguez L, Bueno H, Lanas A Tags: Thromb Haemost Source Type: research

The Clinical Implications of ADAMTS13 Function: The Perspectives of Haemostaseologists
This article reviews the literature in these conditions.
Source: Thrombosis Research - September 19, 2013 Category: Hematology Authors: Savita Rangarajan, Craig Kessler, Louis Aledort Tags: Mini-Reviews Source Type: research

Prospective clinical trial on dosage optimizing of tranexamic acid in non-emergency cardiac surgery procedures.
CONCLUSION: Use of 1 g TxA is safe and sufficient for elective patients with on pump cardiac surgery and thus has been established as strategy of choice in our center. PMID: 24113504 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - October 10, 2013 Category: Hematology Authors: Waldow T, Szlapka M, Haferkorn M, Bürger L, Plötze K, Matschke K Tags: Clin Hemorheol Microcirc Source Type: research

Antithrombotic actions of statins involve PECAM-1 signaling
Statins are widely prescribed cholesterol-lowering drugs that are a first-line treatment of coronary artery disease and atherosclerosis, reducing the incidence of thrombotic events such as myocardial infarction and stroke. Statins have been shown to reduce platelet activation, although the mechanism(s) through which this occurs is unclear. Because several of the characteristic effects of statins on platelets are shared with those elicited by the inhibitory platelet adhesion receptor PECAM-1 (platelet endothelial cell adhesion molecule-1), we investigated a potential connection between the influence of statins on platelet f...
Source: Blood - October 31, 2013 Category: Hematology Authors: Moraes, L. A., Vaiyapuri, S., Sasikumar, P., Ali, M. S., Kriek, N., Sage, T., Gibbins, J. M. Tags: Platelets and Thrombopoiesis Source Type: research

Cocaine in high concentrations inhibits platelet aggregation in vitro.
Abstract Complications of cocaine administration are acute vascular occlusions such as myocardial infarction and stroke. We have studied the influence of cocaine on platelet function in vitro. For that purpose, citrated blood from healthy volunteers was incubated with cocaine concentrations of 0 (control), 10, 100, 1000, 2500, and 10'000 μmol/l plasma. Platelet aggregation was measured in whole blood under high shear flow conditions with a platelet function analyzer PFA-100 using either epinephrine (EPI) or ADP as a platelet activator, as well as in non-flowing blood measuring the change of impedance after the ad...
Source: Clinical Hemorheology and Microcirculation - October 31, 2013 Category: Hematology Authors: Cagienard F, Schulzki T, Reinhart WH Tags: Clin Hemorheol Microcirc Source Type: research

Protein S deficiency and Heerlen polymorphism in a Polish patient with acute myocardial infarction and previous venous thromboembolism
Protein S (PS) deficiency is an autosomal dominant disorder with a prevalence of less than 0.5% in the general European population and 2% to 12% in thrombophilic patients . This deficiency is most frequently caused by missense mutations (HGMD database, http://www.hgmd.org) in the PS gene (PROS1) located on chromosome 3 . Hereditary PS deficiency is an established risk factor for venous thromboembolism (VTE), and few reports have linked this thrombophilic factor with myocardial infarction (MI) or ischemic stroke .
Source: Thrombosis Research - October 10, 2013 Category: Hematology Authors: Ewa Wypasek, Daniel P. Potaczek, Joanna Płonka, Martine Alhenc-Gelas, Anetta Undas Tags: Letters to the Editors-in-Chief Source Type: research

Differences in Thrombotic Risk Factors in Black and White Women with Adverse Pregnancy Outcome
Conclusions: Thrombotic risk factors differ significantly in white and black women with adverse pregnancy outcomes. Such differences highlight the importance of considering race separately when assessing thrombotic risk factors for adverse pregnancy outcomes.
Source: Thrombosis Research - November 18, 2013 Category: Hematology Authors: Claire S. Philipp, Ambarina S. Faiz, Michele G. Beckman, Althea Grant, Paula L. Bockenstedt, John A. Heit, Andra H. James, Roshni Kulkarni, Marilyn J. Manco-Johnson, Stephan Moll, Thomas L. Ortel Tags: Coagulation and Fibrinolysis Source Type: research

Implications of glycoprotein VI for theranostics.
Abstract Glycoprotein VI (GPVI), a membrane glycoprotein solely expressed in platelets and megakaryocytes, plays a critical role in thrombus formation due to collagen/GPVI-mediated platelet activation and adhesion. Recent studies have shown that surface expression of GPVI on circulating platelets is enhanced in acute cardiovascular diseases such as myocardial infarction and ischaemic stroke. Increased GPVI levels are associated with poor clinical outcome and are an early indicator for imminent myocardial infarction in patients with chest pain. The soluble form of the dimeric GPVI fusion protein (sGPVI-Fc) binds wi...
Source: Thrombosis and Haemostasis - February 20, 2014 Category: Hematology Authors: Gawaz M, Vogel S, Pfannenberg C, Pichler B, Langer H, Bigalke B Tags: Thromb Haemost Source Type: research

The DRY Motif at Work: The P2Y12 Receptor Case
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - February 1, 2014 Category: Hematology Authors: G. Enrico Rovati, Valérie Capra Tags: Commentary Source Type: research

The DRY Motif at Work: The P2Y12 Receptor Case.
This article is protected by copyright. All rights reserved. PMID: 24589132 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 3, 2014 Category: Hematology Authors: Rovati GE, Capra V Tags: J Thromb Haemost Source Type: research

CHADS2, CHA2DS2-VASc and HAS-BLED as predictors of outcome in patients with atrial fibrillation undergoing percutaneous coronary intervention
Conclusions: High CHA2DS2-VASc score was the best predictor of thrombotic outcomes after PCI in a high risk AF population. High mHAS-BLED score was not predictive of bleeding events. More accurate, simple risk scores are needed.
Source: Thrombosis Research - January 24, 2014 Category: Hematology Authors: Marja K. Puurunen, Tuomas Kiviniemi, Axel Schlitt, Andrea Rubboli, Britta Dietrich, Pasi Karjalainen, Kai Nyman, Matti Niemelä, Gregory Y.H. Lip, K.E. Juhani Airaksinen Tags: Clinical Studies Source Type: research

Associations of Pentraxin 3 with Cardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis
ConclusionsIn these apparently healthy adults, PTX3 was associated with CVD risk factors, subclinical CVD, CAC and incident coronary heart disease events independent of CRP and CVD risk factors. These results support the hypothesis that PTX3 reflects different aspects of inflammation than CRP and may provide additional insight into the development and progression of atherosclerosis.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - March 1, 2014 Category: Hematology Authors: Nancy Swords Jenny, Roger S. Blumenthal, Richard A. Kronmal, Jerome I. Rotter, David S. Siscovick, Bruce M. Psaty Tags: Original Article ‐ Vascular Biology Source Type: research

Altered fibrin clot structure/function in patients with antiphospholipid syndrome: association with thrombotic manifestation.
Abstract We tested the hypothesis that plasma fibrin clot structure/function is unfavourably altered in patients with antiphospholipid syndrome (APS). Ex vivo plasma clot permeability, turbidity and susceptibility to lysis were determined in 126 consecutive patients with APS enrolled five months or more since thrombotic event vs 105 controls. Patients with both primary and secondary APS were characterized by 11% lower clot permeability (p<0.001), 4.8% shorter lag phase (p<0.001), 10% longer clot lysis time (p<0.001), and 4.7% higher maximum level of D-dimer released from clots (p=0.02) as compared to the ...
Source: Thrombosis and Haemostasis - March 20, 2014 Category: Hematology Authors: Celinska-Lowenhoff M, Iwaniec T, Padjas A, Musial J, Undas A Tags: Thromb Haemost Source Type: research

Randomised, double-blind trial on the value of tapered discontinuation of clopidogrel maintenance therapy after drug-eluting stent implantation. Intracoronary Stenting and Antithrombotic Regimen: CAUTION in Discontinuing Clopidogrel Therapy - ISAR-CAUTION.
In conclusion, tapered discontinuation of chronic clopidogrel therapy is not superior to abrupt discontinuation regarding the primary endpoint in this study. However, the results must be interpreted in view of the premature termination of the trial and low event rates. PMID: 24633406 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 13, 2014 Category: Hematology Authors: Fiedler KA, Mehilli J, Kufner S, Schlichting A, Ibrahim T, Sibbing D, Ott I, Schunkert H, Laugwitz KL, Kastrati A, Schulz S Tags: Thromb Haemost Source Type: research