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Specialty: Hematology
Cancer: Cancer
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Total 99 results found since Jan 2013.
Atrial fibrillation in cancer: thromboembolism and bleeding in daily practice
CONCLUSION: Patients with AF and active cancer experience high rates of thromboembolic and bleeding complications, underlying the complexity of anticoagulant management in these patients. Our data suggest that the presence of cancer is an important factor in determining the indication for anticoagulants in patients with a low CHA2DS2-VASc score.PMID:37063771 | PMC:PMC10099322 | DOI:10.1016/j.rpth.2023.100096
Source: Thrombosis and Haemostasis - April 17, 2023 Category: Hematology Authors: Gordon Chu Jaap Seelig Suzanne C Cannegieter Hans Gelderblom Marcel M C Hovens Menno V Huisman Tom van der Hulle Serge A Trines Andr é J Vlot Henri H Versteeg Martin E W Hemels Frederikus A Klok Source Type: research
Venous thrombosis and risk of cancer in patients with arterial cardiovascular disease
We examined the association between venous thromboembolism and cancer in patients with acute myocardial infarction or stroke.
Source: Thrombosis Research - November 13, 2014 Category: Hematology Authors: Sigrun Alba Johannesdottir Schmidt, Dóra Körmendiné Farkas, Lars Pedersen, Paolo Prandoni, Henrik Toft Sørensen Source Type: research
Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: A nationwide population‐based study
This article is protected by copyright. All rights reserved.
Source: American Journal of Hematology - July 17, 2016 Category: Hematology Authors: Sigurd Broesby‐Olsen, Dóra Körmendiné Farkas, Hanne Vestergaard, Anne Pernille Hermann, Michael Boe Møller, Charlotte Gotthard Mortz, Thomas Kielsgaard Kristensen, Carsten Bindslev‐Jensen, Henrik Toft Sørensen, Henrik Frederiksen Tags: Research Article Source Type: research
Anticoagulation prescribing patterns in patients with cancer
The objective of this retrospective cohort was to describe real-world anticoagulation prescribing patterns in cancer patients at a large academic medical center between January 1, 2013 and October 31, 2016. We sought to assess the safety, tolerability, and efficacy of DOACs in patients with cancer for either VTE and/or AF. Patient demographic, clinical characteristics, as well as bleeding and thrombotic events were collected. There were 214 patients in our analysis, of which 71 patients (33%) received a DOAC [apixaban (n = 22), dabigatran (n = 17), and rivaroxaban (n = 32)]. There were fewer bleeding events an...
Source: Journal of Thrombosis and Thrombolysis - October 19, 2017 Category: Hematology Source Type: research
The Clinical Significance of Fibrin Monomers.
CONCLUSION: Utilizing FM concentrations to assess hyper-coagulable patients seems promising; however, there are limitations including variations in FM cut-off values, the effect of patient medications and the timing of FM measurement relative to an acute event. Thus, further investigation is required before a true advantage for FM as a haemostatic marker can be established.
PMID: 30312978 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - October 12, 2018 Category: Hematology Authors: Refaai MA, Riley P, Mardovina T, Bell PD Tags: Thromb Haemost Source Type: research
Thrombotic events in severe FXII deficiency in comparison with unaffected family members during a long observation period
AbstractTo investigate the occurrence of thrombotic events (myocardial infarction, deep vein thrombosis or ischemic stroke) in a group of 39 cases of severe FXII deficiency during a mean 22.5 years follow-up. All patients seen in Padua during the years 1968–2006 will the object of this investigation. FXII was less than or 1% of normal in all cases. Factor FXII activity in unaffected family members was 98% (range 90–140%). No patient or control had a thrombotic event in the past and none were on anticoagulant therapy. FV Leiden was present in one patient and in two controls whereas the G to A20210 prothrombin polymorp...
Source: Journal of Thrombosis and Thrombolysis - January 29, 2019 Category: Hematology Source Type: research
Screening for clinically relevant drug-drug interactions between direct oral anticoagulants and antineoplastic agents: a pharmacovigilance approach
ConclusionNo signal of DDIs between DOACs and antineoplastic agents was detected, except for DOAC-neratinib. Most DDIs between DOACs and antineoplastic agents may not be clinically relevant. The DDIs between DOACs and neratinib should be further examined in future research.
Source: Journal of Thrombosis and Thrombolysis - August 10, 2023 Category: Hematology Source Type: research
Time trends in pulmonary embolism: A matter of age and gender
Venous thromboembolism (VTE) is the third most common cardiovascular disease . Pulmonary embolism (PE) is potentially lethal and is the most serious manifestation of VTE . Notably, PE is the leading preventable cause of death in hospitalized patients , and is the third most common cardiovascular cause of death after myocardial infarction and stroke in Western world . Risk factors for VTE and PE include old age, surgery, immobilization, trauma, fractures, cancer, pregnancy, puerperium, oral contraceptive pill (OCP) use, and hormone replacement therapy (HRT) . Genetic factors are also important in VTE risk and family history...
Source: Thrombosis Research - June 24, 2013 Category: Hematology Authors: Bengt Zöller Tags: Editorials Source Type: research
Soluble P-selectin: The next step
It has long been recognised that platelets are implicated in both mortality and morbidity in the pathophysiology of a variety of conditions, including coronary artery disease , diabetes , cancer , stroke , and deep vein thrombosis . The success of aspirin in reducing thrombotic events, and the prognostic value of platelet volume, numbers and function in predicting cardiovascular death are further evidence of the importance of this cell. Consequently, the ability to accurately identify those subjects at risk of thrombosis, and possibly those experiencing an acute thrombotic event, is highly sought-after if risk reduction an...
Source: Thrombosis Research - November 11, 2013 Category: Hematology Authors: Andrew D. Blann Tags: Editorials Source Type: research
Lower risk for serious adverse events and no increased risk for cancer after PBSC vs BM donation
In conclusion, SAEs after donation are rare but more often occurred in BM donors and women. In addition, there was no evidence of increased risk for cancer, autoimmune illness, and stroke in donors receiving granulocyte colony-stimulating factor during this period of observation.
Source: Blood - June 5, 2014 Category: Hematology Authors: Pulsipher, M. A., Chitphakdithai, P., Logan, B. R., Navarro, W. H., Levine, J. E., Miller, J. P., Shaw, B. E., O'Donnell, P. V., Majhail, N. S., Confer, D. L. Tags: Transfusion Medicine, Transplantation Source Type: research
Female sex as a risk factor for thromboembolism and death in patients with incident atrial fibrillation. The prospective Danish Diet, Cancer and Health study.
In conclusion, in a relatively young population of patients with atrial fibrillation, female sex was associated with a lower risk of thromboembolism and death.
PMID: 25055988 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 24, 2014 Category: Hematology Authors: Overvad TF, Rasmussen LH, Skjøth F, Overvad K, Albertsen IE, Lane DA, Lip GY, Larsen TB Tags: Thromb Haemost Source Type: research
Emerging pathophysiological roles for fibrinolysis
Purpose of reviewThe fibrinolytic system plays a key role in the regulation of hemostasis and thrombosis; however, it also has multiple pleiotropic effects. In this review, we examine the studies that investigated the role of the plasminogen activator system and its inhibitors outside the context of clot lysis.
Recent findingsActivators of plasminogen, plasminogen receptors, and inhibitors of plasminogen activation all play a role in the proliferation, migration, and metastasis of tumor cells in many cancer types and may serve as prognostic and diagnostic markers. The plasminogen activator system is also involved in the pa...
Source: Current Opinion in Hematology - September 1, 2014 Category: Hematology Tags: HEMOSTASIS AND THROMBOSIS: Edited by Joseph E. Italiano and Jorge A. Di Paola Source Type: research
Global Public Awareness of Venous Thromboembolism
ConclusionsOn a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Aaron M Wendelboe, Micah McCumber, Elaine M Hylek, Harry Buller, Jeffrey I Weitz, Gary Raskob, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research
Global Public Awareness of Venous Thromboembolism.
CONCLUSIONS: On a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder. This article is protected by copyright. All rights reserved.
PMID: 26084415 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 18, 2015 Category: Hematology Authors: Wendelboe AM, McCumber M, Hylek EM, Buller H, Weitz JI, Raskob G, ISTH Steering Committee for World Thrombosis Day Tags: J Thromb Haemost Source Type: research
Global public awareness of venous thromboembolism: comment
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 1, 2015 Category: Hematology Authors: A. Aggarwal, F. R. Rickles Tags: Letter ‐ to the Editor Source Type: research
