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Total 4983 results found since Jan 2013.

Endothelial Trauma From Mechanical Thrombectomy in Acute Stroke: In Vitro Live-Cell Platform With Animal Validation Basic Sciences
Conclusions— In vitro live-cell artificial vessel modeling enables a detailed study of the endothelium after thrombectomy and may contribute to future device design. Large animal studies confirm the relevance of this in vitro system to investigate endothelial physiology. This artificial vessel model may represent a practical, scalable, and physiologically relevant system to assess new endovascular technologies.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Teng, D., Pannell, J. S., Rennert, R. C., Li, J., Li, Y.-S., Wong, V. W., Chien, S., Khalessi, A. A. Tags: Acute Cerebral Infarction, Other Stroke Treatment - Surgical, Other Vascular biology Basic Sciences Source Type: research

Why are most stroke patients deemed poor candidates for intraaterial therapy? A prospective study (P4.306)
Conclusion: The majority of patients presenting to a large tertiary referral center with AIS due to a large vessel occlusion were found to be poor IA candidates, with more than half excluded for a single reason. Such data addressing the volume and proportion of patients found ineligible for IA therapy in real-world practice can help target efforts to develop new interventional options and improve future clinical trial design.Disclosure: Dr. Damania has nothing to disclose. Dr. Noto has nothing to disclose. Dr. Kung has nothing to disclose. Dr. Liew has nothing to disclose. Dr. Finley has nothing to disclose. Dr. Mangla has...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Damania, D., Noto, A., Kung, N., Liew, J., Finley, H., Mangla, R., Miranpuri, A., Sahin, B., Jahromi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Interventional Treatment for Ischemic Stroke Source Type: research

Proposal for a Vascular Computed Tomography-Based Grading System in Posterior Circulation Stroke: A Single-Center Experience
The aim of this study is to investigate the role of a computed tomography angiography (CTA)-based approach in patients undergoing mechanical thrombectomy for vertebrobasilar stroke treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2015 Category: Neurology Authors: Valerio Da Ros, Alessandro Meschini, Roberto Gandini, Costantino Del Giudice, Francesco Garaci, Paolo Stanzione, Barbara Rizzato, Marina Diomedi, Giovanni Simonetti, Roberto Floris, Fabrizio Sallustio Source Type: research

Thrombus Length Estimation on Delayed Gadolinium-Enhanced T1 Clinical Sciences
Conclusions— The dGE-T1, obtained by simply adjusting scanning order in multimodal magnetic resonance imaging protocol, is a useful tool for thrombus length estimation and middle cerebral artery recanalization prediction after IVT.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Yan, S., Chen, Q., Xu, M., Sun, J., Liebeskind, D. S., Lou, M. Tags: Angiography, Ischemic Stroke Clinical Sciences Source Type: research

Patient selection for stroke thrombectomy: Is CT head good enough?
Six randomized controlled trials have established the substantial benefit of mechanical thrombectomy for acute ischemic stroke patients presenting with large vessel occlusive disease.1–6 Enrolling patients with large clinical deficit in the setting of small completed infarct and rapid, complete, or near complete recanalization, and treatment with the most recent generation of thrombectomy devices, contributed to this success. Efforts to generalize the results of these trials beyond select, experienced centers have focused attention on workflow and developing consensus on patient selection. Optimizing outcomes require...
Source: Neurology - July 17, 2016 Category: Neurology Authors: Jadhav, A. P., Wechsler, L. R. Tags: CT, All Cerebrovascular disease/Stroke, Infarction EDITORIALS Source Type: research

Utility of Repeat Cerebrovascular Imaging among Hospitalized Stroke Patients
The purpose of this study is to evaluate the frequency and clinical utility of repeat cerebrovascular imaging with computed tomography angiography (CTA) of the head after contrast-enhanced magnetic resonance angiography (CE-MRA) of the head in acute stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2017 Category: Neurology Authors: Syed Ali Raza, Vijay Javalkar, Seena Dehkharghani, Archana Kudrimoti, Amit Saindane, Mark Mullins, Fadi Nahab Source Type: research

Cerebral angiography and intraarterial thrombolysis with streptokinase in acute ischemic stroke
【Background and Purpose】The purpose of this study was to evaluate the safety and efficacy of intra-arterial thrombolysis (IAT) using Streptokinase under cerebral angiography control (CAC) in patients with acute ischemic stroke due to middle cerebral artery (MCA) occlusion.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Shukhrat Mubarakov, Farrukh Djalalov, Amet Seydaliev Source Type: research

Absent Filling of Ipsilateral Superficial Middle Cerebral Vein Is Associated With Poor Outcome After Reperfusion Therapy Clinical Sciences
Conclusions—Lack of SMCV filling contributed to poor outcome after thrombolysis, especially when reperfusion was not achieved. The main deleterious effect of poor venous filling appears related to the development of brain edema.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Sheng Zhang, Yangxiao Lai, Xinfa Ding, Mark Parsons, John H. Zhang, Min Lou Tags: Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Vascular Anatomy Predicts the Risk of Cerebral Ischemia in Patients Randomized to Carotid Stenting Versus Endarterectomy Clinical Sciences
Background and Purpose—Complex vascular anatomy might increase the risk of procedural stroke during carotid artery stenting (CAS). Randomized controlled trial evidence that vascular anatomy should inform the choice between CAS and carotid endarterectomy (CEA) has been lacking.Methods—One-hundred eighty-four patients with symptomatic internal carotid artery stenosis who were randomly assigned to CAS or CEA in the ICSS (International Carotid Stenting Study) underwent magnetic resonance (n=126) or computed tomographic angiography (n=58) at baseline and brain magnetic resonance imaging before and after treatment. We invest...
Source: Stroke - April 24, 2017 Category: Neurology Authors: Mandy D. Muller, Frank J. Ahlhelm, Alexander von Hessling, David Doig, Paul J. Nederkoorn, Sumaira Macdonald, Philippe A. Lyrer, Aad van der Lugt, Jeroen Hendrikse, Christoph Stippich, H. Bart van der Worp, Toby Richards, Martin M. Brown, Stefan T. Engelt Tags: Magnetic Resonance Imaging (MRI), Revascularization, Stent, Cerebrovascular Disease/Stroke, Stenosis Original Contributions Source Type: research

Angiographic Microcirculatory Obstructions Distal to Occlusion Signify Poor Outcome after Endovascular Treatment for Acute Ischemic Stroke
In this study, we retrospectively evaluated presence of contrast stasis and absence of capillary blush on angiograms obtained by selective injections into the distal site of occlusive thrombi, prior to deployment of stentrievers, in patients undergoing endovascular treatment for acute MCA occlusion. The role of this novel angiographic strategy assessing distal antegrade flow in predicting procedural and clinical outcome was compared to previously defined, prognostic angiographic characteristics. A total of 7 (21%) out of 34 patients had contrast stasis and lack of capillary blush downstream to the injection site. None of t...
Source: Translational Stroke Research - August 19, 2017 Category: Neurology Source Type: research

An Acute Ischemic Stroke Resulting from Aortic Dissection
A 39-year-old man with syncope and persistent dizziness was sent to stroke emergency. Patient's diffusion magnetic resonance imaging of brain showed acute ischemia in right cerebella and right occipital lobe, thus intravenous recombinant tissue plasminogen activator was given to him. However, the patient behaved rather restless with repeated complaint of back and thoracic pain. Further thorax computed tomography angiography confirmed that the underlying cause turned out to be aortic dissection.
Source: Journal of Stroke and Cerebrovascular Diseases - September 19, 2017 Category: Neurology Authors: Zijun He, Chun-sen Shen, Bin Wang, Yongchun Luo Tags: Case Studies Source Type: research

Radiographic and Clinical Brain Infarcts in Cardiac and Diagnostic Procedures Clinical Sciences
Conclusions—One of 10 people with periprocedural RBIs during cardiac surgeries and invasive vascular diagnostic procedures resulted in strokes or transient ischemic attacks, which may serve as a potential surrogate marker of procedural proficiency and perhaps as a predictor of risk for periprocedural strokes.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Sung-Min Cho, Abhishek Deshpande, Vinay Pasupuleti, Adrian V. Hernandez, Ken Uchino Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Impact of thrombus length on recanalization and clinical outcome following mechanical thrombectomy in acute ischemic stroke
Conclusions In this study, thrombus length had no relevant impact on recanalization, neurological outcome, or intraprocedural complications following mechanical thrombectomy of middle cerebral artery occlusions. Therefore, mechanical thrombectomy with stent retrievers can be attempted with large clots.
Source: Journal of NeuroInterventional Surgery - September 12, 2017 Category: Neurosurgery Authors: Seker, F., Pfaff, J., Wolf, M., Schönenberger, S., Nagel, S., Herweh, C., Pham, M., Bendszus, M., Möhlenbruch, M. A. Tags: Ischemic stroke Source Type: research

Histology of Thrombectomy Specimen Reveals Cardiac Tumor Embolus in Cryptogenic Young Stroke
A 25-year-old woman presented with acute onset of right hemiplegia and global aphasia with National Institutes of Health Stroke Scale score of 19. Computed tomography angiography demonstrated occlusion of the left proximal middle cerebral artery. She was thrombolysed with intravenous recombinant tissue plasminogen activator (0.6  mg/kg) within 3 hours of onset of symptoms and was taken up for mechanical thrombectomy. The retrieved specimen appeared pale white and soft; histopathologic examination revealed a papillary neoplasm composed of papillae with hyalinized cores lined by endothelium, consistent with papillary fibro...
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2017 Category: Neurology Authors: Kizhakkaniyakath Abdu Salam, Mohammed Rafeeque, Hisham Hashim, Neena Mampilly, Mohan Leslie Noone Tags: Case Studies Source Type: research

Multivessel Occlusion in Patients Subjected to Thrombectomy Clinical Sciences
Background and Purpose—Patients with embolic large-vessel occlusion may present with additional coincidental acute occlusions within or distant from the involved territory, referred to as multivessel occlusion (MVO). Purpose of this study was to assess prevalence of MVO, associated factors, and clinical relevance in patients undergoing endovascular stroke treatment.Methods—Image data of consecutive endovascular candidates (n=720) with direct access to angiography were extracted from a prospective registry. Prevalence of MVO was assessed with multimodal magnetic resonance imaging/computed tomography and confirmed by int...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Johannes Kaesmacher, Pascal J. Mosimann, Mattia Giarrusso, Marwan El-Koussy, Felix Zibold, Eike Piechowiak, Tomas Dobrocky, Raphael Meier, Simon Jung, Sebastian Bellwald, Marcel Arnold, Pasquale Mordasini, Urs Fischer, Jan Gralla Tags: Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research