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Procedure: Kidney Transplant
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Total 842 results found since Jan 2013.
U.S. FDA Approves TECVAYLI ™ (teclistamab-cqyv), the First Bispecific T-cell Engager Antibody for the Treatment of Patients with Relapsed or Refractory Multiple Myeloma
HORSHAM, Pa., October 25, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the U.S. Food and Drug Administration (FDA) approved TECVAYLI™ (teclistamab-cqyv) for the treatment of adult patients with relapsed or refractory multiple myeloma, who previously received four or more prior lines of therapy, including a proteasome inhibitor, immunomodulatory drug and anti-CD38 monoclonal antibody.1 TECVAYLI™ is a first-in-class, bispecific T-cell engager antibody that is administered as a subcutaneous treatment.1 This off-the-shelf (or ready to use) therapy uses innovative science to ac...
Source: Johnson and Johnson - October 25, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study
CONCLUSION: Non-selected patients aged 50 years or above with AKI during admission had significantly higher one-year risk of cardiovascular event or death, especially, but not only due to heart failure, independent of age and eGFR.PMID:36210122 | DOI:10.1016/j.nefroe.2022.06.003
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - October 9, 2022 Category: Urology & Nephrology Authors: Philip Andreas Schytz Paul Blanche Anders Bonde Nissen Christian Torp-Pedersen Gunnar H Gislason Karl Emil Nelveg-Kristensen Kristine Hommel Nicholas Carlson Source Type: research
Expanded Criteria Donors
Exp Clin Transplant. 2022 Aug;20(Suppl 4):13-19. doi: 10.6002/ect.DonorSymp.2022.L13.ABSTRACTThe expanded criteria donor is any donor over the age of 60 years or a donor over the age of 50 years with 2 of the following 3 items: (1) history of high blood pressure, (2) serum creatinine ≥1.5 mg/dL, and (3) death due to stroke. To accept an expanded criteria donor kidney may significantly decrease the amount of time a person waits for transplant but requires written informed consent from the recipient. Although expanded criteria donor kidneys have predictably shorter outcomes than standard criteria donors, the exact risk is ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - August 26, 2022 Category: Transplant Surgery Authors: Hassan Argani Source Type: research
Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease
CONCLUSIONS: HIF stabiliser management of anaemia had uncertain effects on CV death, fatigue, death (any cause), CV outcomes, and kidney failure compared to placebo or ESAs. Compared to placebo or ESAs, HIF stabiliser management of anaemia probably decreased the proportion of patients requiring blood transfusions, and probably increased the proportion of patients reaching the target Hb when compared to placebo.PMID:36005278 | DOI:10.1002/14651858.CD013751.pub2
Source: Cochrane Database of Systematic Reviews - August 25, 2022 Category: General Medicine Authors: Patrizia Natale Suetonia C Palmer Allison Jaure Elisabeth M Hodson Marinella Ruospo Tess E Cooper Deirdre Hahn Valeria M Saglimbene Jonathan C Craig Giovanni Fm Strippoli Source Type: research
The Prevalence of Neurological Complication after Renal Transplantation
CONCLUSIONS: Headache had the highest incidence (55%) in the nervous system after KT, followed by nervous system CMV infection (38%) and stroke (5%). Nevertheless, due to the inconsistencies in the types of NCs included and the follow-up time, our results might only serve as an epidemiological reference for the specific incidence differences.PMID:35832523 | PMC:PMC9273377 | DOI:10.1155/2022/8763304
Source: Evidence-based Complementary and Alternative Medicine - July 14, 2022 Category: Complementary Medicine Authors: Xiaorong Zhu Liangrong Shen Dan Li Luoning Shi Qing Zhang Source Type: research
What to Know About High Cholesterol in Kids
Heart disease is the leading cause of death in the U.S., but it’s not something we usually associate with kids. In many cases, however, the seeds of heart attacks and strokes may be sown in childhood.
That’s because high or abnormal cholesterol levels, which are a major risk factor for heart disease and stroke, are not uncommon in kids. “People may feel that cholesterol is mostly an adult issue, which is not correct,” says Dr. Nivedita Patni, a pediatric endocrinologist at Children’s Health in Dallas and an assistant professor of pediatrics at UT Southwestern Medical Center.
About 1 in 5 child...
Source: TIME: Health - July 13, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news
The Footprint of Kynurenine Pathway in Cardiovascular Diseases
Int J Tryptophan Res. 2022 Jun 28;15:11786469221096643. doi: 10.1177/11786469221096643. eCollection 2022.ABSTRACTKynurenine pathway is the main route of tryptophan metabolism and produces several metabolites with various biologic properties. It has been uncovered that several cardiovascular diseases are associated with the overactivation of kynurenine pathway and kynurenine and its metabolites have diagnostic and prognostic value in cardiovascular diseases. Furthermore, it was found that several kynurenine metabolites can differently affect cardiovascular health. For instance, preclinical studies have shown that kynurenine...
Source: Atherosclerosis - July 5, 2022 Category: Cardiology Authors: Moein Ala Seyed Parsa Eftekhar Source Type: research
A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation.
Major adverse cardiovascular event (MACE) rates immediately after kidney transplantation remain uncertain due to heterogeneous reporting in the literature. To clarify this, we retrospectively studied every eligible kidney transplant procedure performed in England between April 1, 2002 and March 31. 2018 with follow-up through August 31, 2019. The primary outcome of interest was MACE broadly defined as any hospital admission with myocardial infarction, stroke, unstable angina, heart failure, any coronary revascularisation procedure and/or any cardiovascular death.
Source: Kidney International - June 15, 2022 Category: Urology & Nephrology Authors: Benjamin Anderson, Muhammad Qasim, Felicity Evison, Suzy Gallier, Jonathan N. Townend, Charles J. Ferro, Adnan Sharif Tags: clinical investigation Source Type: research
CZecking heart failure in patients with advanced chronic kidney disease (Czech HF-CKD): Study protocol
DISCUSSION: This trial will differ from others by: (1) detailed repeated hemodynamic assessment including arteriovenous access flow and (2) by careful assessment of adequate hydration to avoid confusion between HF and water overload.PMID:35676802 | DOI:10.1177/11297298221099843
Source: The Journal of Vascular Access - June 9, 2022 Category: Surgery Authors: Jan Malik Anna Valerianova Satu Sinikka Pesickova Zdenka Hruskova Vladimira Bednarova Pavel Michalek Vladimir Polakovic Vladimir Tesar Source Type: research
Defective KIM-1 phagocytosis does not predispose to acute graft dysfunction after kidney transplantation in humans
Introduction: Ischemia reperfusion injury (IRI) is common to several pathologic conditions, including myocardial infarction, stroke, acute kidney injury, and delayed graft function after kidney transplantation1. Clearance of apoptotic and necrotic cells by resident immune or epithelial cellsS1,S2 prevents release of harmful intracellular pro-inflammatory mediators, and is thought to represent an important mechanism to dampen secondary tissue damage and promote repair after acute injury including IRI2, 3, S3, S4.
Source: Kidney International - May 27, 2022 Category: Urology & Nephrology Authors: Rita S. Suri, Ji Yun Lee, Matthew R. Ban, Bradly Shrum, Elena Tutunea-Fatan, Ola Z. Ismail, Steven Leckie, Adam McIntyre, Qingyong Xu, Seung Ho Lee, Sonali de Chickera, Robert A. Hegele, Lakshman Gunaratnam Tags: research letter Source Type: research
