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Specialty: Neuroscience
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Total 46 results found since Jan 2013.

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments
Publication date: 15 July 2015 Source:Neuron, Volume 87, Issue 2 Author(s): Paul M. George, Gary K. Steinberg Stroke remains a leading cause of death and disability in the world. Over the past few decades our understanding of the pathophysiology of stroke has increased, but greater insight is required to advance the field of stroke recovery. Clinical treatments have improved in the acute time window, but long-term therapeutics remain limited. Complex neural circuits damaged by ischemia make restoration of function after stroke difficult. New therapeutic approaches, including cell transplantation or stimulation, focus...
Source: Neuron - July 17, 2015 Category: Neuroscience Source Type: research

Stem Cell Therapy for Abrogating Stroke-Induced Neuroinflammation and Relevant Secondary Cell Death Mechanisms
Publication date: Available online 23 July 2017 Source:Progress in Neurobiology Author(s): Connor Stonesifer, Sydney Corey, Shaila Ghanekar, Zachary Diamandis, Sandra A. Acosta, Cesar V. Borlongan Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke is the upregulation of endogenous neuroinflammatory processes to levels that destroy hypoxic tissue local to the area of insult, induce apoptosis, and initiate a feedback loop of inflammatory cascades that can expand the region of damage. Stem cell therapy has ...
Source: Progress in Neurobiology - July 23, 2017 Category: Neuroscience Source Type: research

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke.
CONCLUSIONS: Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation. PMID: 24393245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, Zhuge QC, Xie LK, Wang B, Su DM, Jin KL Tags: CNS Neurosci Ther Source Type: research

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke.
Abstract Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-ba...
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Tang YH, Ma YY, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke
In this study, we transplanted exogenous NSCs into the ipsilateral hemisphere of male rats in combination with ZL006 treatment after ischemic stroke. We show that ZL006 treatment facilitates the migration of transplanted NSCs into the ischemia‐injured area and promotes neuronal differentiation of these cells, which is not due to a direct effect of ZL006 on exogenous NSCs but is associated with increased phosphorylation of cAMP response element–binding protein (CREB) in neurons and favorable microenvironment. Moreover, improved functional outcome in the ZL006‐treated group was also found. Taken together, our data indi...
Source: Journal of Neuroscience Research - May 17, 2017 Category: Neuroscience Authors: Dong ‐Liang Wang, Xiao‐Dan Qian, Yu‐Hui Lin, Bin‐Bin Tian, Hai‐Ying Liang, Lei Chang, Hai‐Yin Wu, Dong‐Ya Zhu, Chun‐Xia Luo Tags: RESEARCH ARTICLE Source Type: research

Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.
CONCLUSION: These findings highlight the therapeutic effects of EPI-NCSCs transplantation, probably through simultaneous induction of neuronal and glial formation, as well as Bdnf over-expression in a rat model of ischemic stroke. PMID: 32281225 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - April 11, 2020 Category: Neuroscience Authors: Salehi MS, Pandamooz S, Safari A, Jurek B, Tamadon A, Namavar MR, Dianatpour M, Dargahi L, Azarpira N, Fattahi S, Shid Moosavi SM, Keshavarz S, Khodabandeh Z, Zare S, Nazari S, Heidari M, Izadi S, Poursadeghfard M, Borhani-Haghighi A Tags: CNS Neurosci Ther Source Type: research

Pifithrin-α Enhances the Survival of Transplanted Neural Stem Cells in Stroke Rats by Inhibiting p53 Nuclear Translocation.
CONCLUSION: Our results indicate that PFT-α enhances the survival of grafted NSCs through the inhibition of p53 translocation into the nucleus. PMID: 23253187 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 18, 2012 Category: Neuroscience Authors: Lei XH, Zhao D, Li YL, Li XF, Sun X, Du WZ, Sun Y, Hao ZF, Xin SY, Liu C, Zhang ZR, Jiang CL Tags: CNS Neurosci Ther Source Type: research

Vascular remodeling after ischemic stroke: Mechanisms and therapeutic potentials
Publication date: April 2014 Source:Progress in Neurobiology, Volume 115 Author(s): Jialing Liu , Yongting Wang , Yosuke Akamatsu , Chih Cheng Lee , R. Anne Stetler , Michael T. Lawton , Guo-Yuan Yang The brain vasculature has been increasingly recognized as a key player that directs brain development, regulates homeostasis, and contributes to pathological processes. Following ischemic stroke, the reduction of blood flow elicits a cascade of changes and leads to vascular remodeling. However, the temporal profile of vascular changes after stroke is not well understood. Growing evidence suggests that the early phase of cer...
Source: Progress in Neurobiology - November 9, 2014 Category: Neuroscience Source Type: research

Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation
Publication date: 14 February 2018 Source:Neuroscience Letters, Volume 666 Author(s): Nina Kosi, Ivan Alić, Iva Salamon, Dinko Mitrečić Although transplantation of stem cells improves recovery of the nervous tissue, little is known about the influence of different brain regions on transplanted cells. After we confirmed that cells with uniform differentiation potential can be generated in independent experiments, one million of neural stem cells isolated from B6.Cg-Tg(Thy1-YFP)16Jrs/J mouse embryos were transplanted into the brain 24 h after induction of stroke. The lateral ventricles, the corpus callosum and the stri...
Source: Neuroscience Letters - January 4, 2018 Category: Neuroscience Source Type: research

Transplantation of Roxadustat-preconditioned bone marrow stromal cells improves neurological function recovery through enhancing grafted cell survival in ischemic stroke rats
CONCLUSIONS: FG-4592 pretreated BMSCs improve neurological function recovery after stroke and are likely to be a promising strategy for stroke management.PMID:35695696 | DOI:10.1111/cns.13890
Source: CNS Neuroscience and Therapeutics - June 13, 2022 Category: Neuroscience Authors: Jiayu Chen Xiao Lin Chaojie Yao Lebohang Anesu Bingwa Hao Wang Zhongxiao Lin Kunlin Jin Qichuan Zhuge Su Yang Source Type: research

Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice
CONCLUSION: The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke.PMID:37592866 | DOI:10.1111/cns.14412
Source: CNS Neuroscience and Therapeutics - August 18, 2023 Category: Neuroscience Authors: Yu Yang Qianqian Liu Song Deng Qian Shao Long Peng Yuejuan Ling Yue Huang Siqi Zheng Qiaoji Jiang Dekang Nie Jian Chen Source Type: research