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Design of Randomized, double‐blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate vs. acetylsalicylic acid in patients with Embolic Stroke of Undetermined Source (RE‐SPECT ESUS)
DiscussionAcetylsalicylic acid is the most common antithrombotic given to patients with embolic strokes of undetermined source to reduce recurrence risk. This trial will determine whether anticoagulation with dabigatran is more effective than acetylsalicylic acid, and acceptably safe.
Source: International Journal of Stroke - September 30, 2015 Category: Neurology Authors: Hans‐Christoph Diener, J. Donald Easton, Christopher B. Granger, Lisa Cronin, Christine Duffy, Daniel Cotton, Martina Brueckmann, Ralph L. Sacco, Tags: Protocol Source Type: research

Design of Randomized, double ‐blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate vs. acetylsalicylic acid in patients with Embolic Stroke of Undetermined Source (RE‐SPECT ESUS)
DiscussionAcetylsalicylic acid is the most common antithrombotic given to patients with embolic strokes of undetermined source to reduce recurrence risk. This trial will determine whether anticoagulation with dabigatran is more effective than acetylsalicylic acid, and acceptably safe.
Source: International Journal of Stroke - September 29, 2015 Category: Neurology Authors: Hans ‐Christoph Diener, J. Donald Easton, Christopher B. Granger, Lisa Cronin, Christine Duffy, Daniel Cotton, Martina Brueckmann, Ralph L. Sacco, Tags: Protocol Source Type: research

Impact of Co-morbidity on the Risk of First-Time Myocardial Infarction, Stroke, or Death After Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
In conclusion, independently of co-morbidity level, an abnormal SPECT MPI scan was associated with an increased 10-year risk of myocardial infarction and all-cause death but not stroke.
Source: The American Journal of Cardiology - June 9, 2014 Category: Cardiology Authors: Astrid Blicher Schelde, Morten Schmidt, Morten Madsen, Karin Lottrup Petersen, Søren Steen Nielsen, Jørgen Frøkiær, Henrik Toft Sørensen, Christian Fynbo Christiansen Tags: Coronary Artery Disease Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes
CONCLUSION: While sNfL concentrations did not show a diagnostic role for fCAD, in contrast, sNfL was a strong and independent predictor of cardiovascular outcomes, including all-cause death, cardiovascular death and stroke/TIA.PMID:36714921 | DOI:10.1080/1354750X.2023.2172211
Source: Biomarkers - January 30, 2023 Category: Research Authors: Melissa Amrein None Stephanie Meier Ibrahim Sch äfer Sabine Schaedelin Eline Willemse Pascal Benkert Joan Walter Christian Puelacher Tobias Zimmermann Daniela Median Caroline Egli David Leppert Raphael Twerenbold Michael Zellweger Jens Kuhle Christian Mu Source Type: research

Risk Stratification of Cardiovascular Events in Very Elderly Patients with Known or Suspected Coronary Artery Disease Who had Normal Single-photon Emission Computed Tomographic Myocardial Perfusion Imaging Findings.
Conclusion The MCV event rate was high in very elderly patients despite their normal SPECT MPI findings at baseline. Therefore, very elderly patients with multivariate risks should be carefully followed to avoid a poor prognosis. PMID: 31366795 [PubMed - as supplied by publisher]
Source: Internal Medicine - August 3, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Predictive Value of Coronary Blood Flow for Future Cardiovascular Events in Patients with Atrial Fibrillation
Atrial fibrillation (AF) is associated with impaired coronary flow and diminished myocardial perfusion [1–3]. In a previous study, we demonstrated that patients with AF in the absence of obstructive coronary artery disease (CAD) have significantly higher Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) for all three coronary vessels compared to the control subjects without AF [1]. However, the clinical importance of the increased TFC in AF patients has not been fully elucidated, although TFC seems to be independently associated with mean platelet volume [4], an independent risk factor for future stroke and ...
Source: International Journal of Cardiology - August 22, 2014 Category: Cardiology Authors: Chufan Luo, Lichun Wang, Chong Feng, Wangjian Zhang, Zhibin Huang, Yuantao Hao, Anli Tang, Xiuren Gao Source Type: research

Impact of Co-morbidity on the Risk of First-Time Myocardial Infarction, Stroke, or Death After Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging
Source: The American Journal of Cardiology - June 5, 2014 Category: Cardiology Authors: Astrid Blicher Schelde, Morten Schmidt, Morten Madsen, Karin Lottrup Petersen, Søren Steen Nielsen, Jørgen Frøkiær, Henrik Toft Sørensen, Christian Fynbo Christiansen Source Type: research

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