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Total 394 results found since Jan 2013.

A Radiologist ’s Primer on Bundles and Care Episodes
Publication date: September 2016 Source:Journal of the American College of Radiology, Volume 13, Issue 9 Author(s): David Seidenwurm, Frank James Lexa Bundled or episode payments are among the most heavily emphasized approaches to aligning incentives and promoting care coordination, efficiency, and accountability in health care redesign. Bundled or episode payments price a market basket of services for an entire episode of care with both a clearly defined trigger and termination. Because the radiologist is “ancillary” in many bundles, the specialty is often unaware of the phenomenon. This is likely to change rapidly. ...
Source: Journal of the American College of Radiology - August 31, 2016 Category: Radiology Source Type: research

Medtronic touts CRT study showing heightened medication adherence
Patients implanted with cardiac resynchronization devices showed a greater rate of adherence to their medication regiments after their CRT devices were put it, according to a retrospective study Medtronic (NYSE:MDT) touted today. The analysis examined data from 4,512 patients who received CRT devices between January 2008 and December 2014, evaluating adherence to recommended medications before and after CRT implantation. Compliance increased 67% 2 years after CRT implantation when compared to 2 years pre-implantation, Fridley, Minn.-based Medtronic said. “These data support our commitment to understanding how we can...
Source: Mass Device - September 19, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Cardiovascular Clinical Trials Cardiac Rhythm Management Medtronic Source Type: news

Tau Imaging Among Breakthroughs Advancing the Fight against Alzheimer ' s
Worldwide,  nearly44 million  people now have Alzheimer ' s disease (AD) or related dementia, making these conditions the  top cause of disabilities in later life. The biopharma industry has invested billions of dollars into research to treat and prevent AD1, yet this work has faced many obstacles, including difficulty identifying biomarkers, tracking the disease ’s progress in the brain, and recruiting patients to trials while they are still asymptomatic. But in recent years, we’ve begun to see breakthroughs that is driving our research in new directions. Many of these accomplishments were highlighted at the Alzh...
Source: EyeForPharma - September 21, 2016 Category: Pharmaceuticals Authors: Olga Uspenskaya-Cadoz Source Type: news

Application and outcomes of therapy combining transcranial direct current stimulation and virtual reality: a systematic review.
CONCLUSIONS: The use of tDCS combined with VR showed positive results in both healthy and impaired patients. Future studies with larger sample sizes and homogeneous participants are required to confirm the benefits of tDCS and VR. Implications for Rehabilitation tDCS with VR intervention can be an alternative to traditional rehabilitation programs. tDCS with VR is a promising type of intervention with a variety of positive effects. Application of tDCS with VR is appropriated to both healthy and impaired patients. There is no consensus of tDCS with VR application. PMID: 27677678 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation. Assistive Technology. - September 26, 2016 Category: Rehabilitation Authors: Massetti T, Crocetta TB, Silva TD, Trevizan IL, Arab C, Caromano FA, Monteiro CB Tags: Disabil Rehabil Assist Technol Source Type: research

Delirium after cardiac surgery: A pilot study from a single tertiary referral center.
CONCLUSIONS: Patients who developed delirium had systemic disease in the form of hypertension and cerebrovascular disease. Delirium was seen in patients who had higher postoperative pain scores, longer ICU stay, and NIV use. This study can be used to develop a predictive tool for diagnosing postcardiac surgical delirium. PMID: 28074801 [PubMed - in process]
Source: Annals of Cardiac Anaesthesia - December 31, 2016 Category: Anesthesiology Authors: Kumar AK, Jayant A, Arya VK, Magoon R, Sharma R Tags: Ann Card Anaesth Source Type: research

The evolving role of oral hormonal therapies and review of conjugated estrogens/bazedoxifene for the management of menopausal symptoms.
Authors: Parish SJ, Gillespie JA Abstract This review describes the evolving role of oral hormone therapy (HT) for treating menopausal symptoms and preventing osteoporosis, focusing on conjugated estrogens/bazedoxifene (CE/BZA). Estrogens alleviate hot flushes and prevent bone loss associated with menopause. In nonhysterectomized women, a progestin should be added to estrogens to reduce the risk of endometrial cancer. Use of HT declined since the Women's Health Initiative (WHI) studies showed that HT does not prevent coronary heart disease (CHD) and that conjugated estrogens/medroxyprogesterone acetate increased th...
Source: Postgraduate Medicine - February 1, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Dementia and co ‐occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?
ConclusionsThis review summarizes that living with significant cognitive impairment or dementia negatively impacts mortality, institutionalization, and functional outcomes for people living with multiple chronic conditions. Our findings suggest that chronic‐disease management interventions will need to address co‐occurring cognitive impairment. Copyright © 2017 John Wiley & Sons, Ltd.
Source: International Journal of Geriatric Psychiatry - January 31, 2017 Category: Geriatrics Authors: Mark B. Snowden, Lesley E. Steinman, Lucinda L. Bryant, Monique M. Cherrier, Kurt J. Greenlund, Katherine H. Leith, Cari Levy, Rebecca G. Logsdon, Catherine Copeland, Mia Vogel, Lynda A. Anderson, David C. Atkins, Janice F. Bell, Annette L. Fitzpatrick Tags: Review Article Source Type: research

Getting Social in the Real World
Although it would be facetious to say that social media has reached a tipping point into ubiquity, it is only relatively recently that it has been used by pharma to collect and analyze patient data. This use of social media may only be in its infancy but as a quick and inexpensive way to gather large-scale, real-world data it is growing rapidly.Technology always outstrips the glacial pace that industry moves at, but this ‘sudden’ move creates a sharp learning curve for many pharma companies. Issues around regulation and resources will hinder some, while others will fail to see the value of ‘social health’.Popular s...
Source: EyeForPharma - March 6, 2017 Category: Pharmaceuticals Authors: Danielle Barron Source Type: news

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

Practice patterns for spasticity management with phenol neurolysis.
CONCLUSION: Phenol neurolysis is currently used to reduce spasticity for various functional goals, including preventing contractures and improving gait. Depending on the pattern of spasticity displayed, numerous peripheral nerves in the upper and lower extremities can be targeted for treatment with phenol neurolysis. Further research into its role in spasticity management, including studies exploring its cost-effectiveness and pharmacological and side-effects compared with other treatment options are needed. PMID: 28537343 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - May 26, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Nonsteroidal anti-inflammatory drugs and cardiovascular safety - translating pharmacological data into clinical readouts.
Authors: Tacconelli S, Bruno A, Grande R, Ballerini P, Patrignani P Abstract INTRODUCTION: The pharmacological management of pain includes the use of nonsteroidal anti-inflammatory drugs(NSAIDs). They comprise traditional(t) NSAIDs and selective cyclooxygenase(COX)-2 inhibitors (named coxibs). The analgesic and anti-inflammatory effects of NSAIDs are dependent on the extent and duration of COX-2 inhibition in the spinal cord and inflammatory sites. However, the simultaneous inhibition of COX-2 in the vasculature translates into a prothrombotic phenotype and promotes hypertension and heart failure. Areas covered. Th...
Source: Expert Opinion on Drug Safety - June 2, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Uses of Electrical Stimulation for the Rehabilitation of People with Multiple Sclerosis: A Review
AbstractPurpose of ReviewThe aim of this review is to summarize the literature regarding use of electrical stimulation in the rehabilitation of people with multiple sclerosis (MS).Recent FindingsWhile significant work has been done to study the effect of electrical stimulation in stroke and spinal cord injury, few studies have looked at degenerative diseases including MS.SummaryTo date, limited high-quality evidence is available to demonstrate definitive benefits of electrical stimulation. This review considers the potential benefits of electrical stimulation for the management of foot drop, pain, spasticity, weakness, and...
Source: Current Physical Medicine and Rehabilitation Reports - July 25, 2017 Category: Rehabilitation Source Type: research

Foot Problems in Older Adults: Associations with Incident Falls, Frailty Syndrome and Sensor-Derived Gait, Balance, and Physical Activity Measures.
CONCLUSIONS: Foot problems were associated with frailty level and decreased motor performance and PA. Wearable technology is a practical way to screen for deterioration in gait, balance, and PA that may be associated with foot problems. Routine assessment and management of foot problems could promote earlier intervention to retain motor performance and manage fear of falling among older adults, which may ultimately improve healthy aging and reduce risk of frailty. PMID: 28853612 [PubMed - as supplied by publisher]
Source: Journal of the American Podiatric Medical Association - August 30, 2017 Category: Podiatry Authors: Muchna A, Najafi B, Wendel CS, Schwenk M, Armstrong DG, Mohler J Tags: J Am Podiatr Med Assoc Source Type: research

Medtronic wins CE Mark for Intellis SCS, PNS systems
Medtronic (NYSE:MDT) said today it won CE Mark approval in the European Union for its Intellis spinal cord stimulation and peripheral nerve stimulation systems designed to treat chronic pain. The Fridley, Minn.-based company touted the Intellis as the world’s smallest fully implantable SCS neurostim. The newly-cleared system includes improved battery performance and is managed through the use of a Samsung Galaxy Tab S2 tablet. “Medtronic’s goal is to simplify treatment and improve the patient experience with personalized therapy that provides long-term pain relief and helps restore function. The launch ...
Source: Mass Device - November 6, 2017 Category: Medical Devices Authors: Fink Densford Tags: Neuromodulation/Neurostimulation Pain Management Regulatory/Compliance Medtronic Source Type: news

Not as Simple as Canker Sores
BY ​NANA P. MATSUMOTO, & DEREK MEEKS, DO​​A 16-year-old boy presented to a rural ED with a swollen jaw, painful blisters in the mouth, and earache for the past day. One week before, he had a fever with chills, sore throat, and dry coughs. He was not taking any medications, and his immunizations were up-to-date. He had a mild learning disorder but no significant past medical or surgical history.​An apthous ulcer, the most common and one of the earliest signs of Behçet's disease.The patient's vital signs were within normal limits, and his physical examination revealed anterior cervical lymphadenopathy, sinus con...
Source: The Case Files - October 11, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research