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Specialty: Drugs & Pharmacology
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Total 5519 results found since Jan 2013.
Comparing adverse Events of tenecteplase and alteplase: A Real-World analysis of the FDA adverse Event Reporting System (FAERS)
CONCLUSION: This study identified and compared signals of ADRs associated with tenecteplase and alteplase, although tenecteplase is as effective as alteplase and has advantages such as ease of use and affordability, it cannot replace alteplase in the treatment of AIS until its safety profile is fully recognized. Additionally, previously unreported ocular ADRs and pneumonia were identified, providing valuable insights into the relationship between ADRs and the use of these thrombolytic drugs. These findings underscore the importance of continuous monitoring and effective detection of AEs to ultimately enhance the safety of ...
Source: Expert Opinion on Drug Safety - August 9, 2023 Category: Drugs & Pharmacology Authors: Fang-E Shi Zhe Yu Chengyue Sun Peiliang Gao Haiyan Zhang Jihong Zhu Source Type: research
The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research
Tight junction proteins related to blood-brain barrier and their regulatory signaling pathways in ischemic stroke
Biomed Pharmacother. 2023 Aug 4;165:115272. doi: 10.1016/j.biopha.2023.115272. Online ahead of print.ABSTRACTTight junctions (TJs) are crucial for intercellular connections. The abnormal expression of proteins related to TJs can result in TJ destruction, structural damage, and endothelial and epithelial cell dysfunction. These factors are associated with the occurrence and progression of several diseases. Studies have shown that blood-brain barrier (BBB) damage and dysfunction are the prominent pathological features of stroke. TJs are directly associated with the BBB integrity. In this article, we first discuss the structu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 6, 2023 Category: Drugs & Pharmacology Authors: Xiangyi Zheng Beida Ren Ying Gao Source Type: research
Development of microRNA-based therapeutics for central nervous system diseases
Eur J Pharmacol. 2023 Aug 2:175956. doi: 10.1016/j.ejphar.2023.175956. Online ahead of print.ABSTRACTMicroRNA (miRNA)-mediated gene silencing is a method of RNA interference in which a miRNA binds to messenger RNA sequences and regulates target gene expression. MiRNA-based therapeutics have shown promise in treating a variety of central nervous system diseases, as verified by results from diverse preclinical model organisms. Over the last decade, several miRNA-based therapeutics have entered clinical trials for various kinds of diseases, such as tumors, infections, and inherited diseases. However, such clinical trials for ...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Siqi Xia Chaoran Xu Fuyi Liu Gao Chen Source Type: research
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE < sup > -/- < /sup > mice via suppressing inflammation, endothelial necroptosis and apoptosis
This study aims to explore whether NBP is able to improve endothelium-dependent vasodilation in atherosclerosis and the underlying mechanisms. Male ApoE-/- mice were fed with a high-fat diet (HFD) for 9-16 weeks to establish a model of atherosclerosis. NBP were given to the mice after eating HFD for 6 weeks and atorvastatin served as a positive control. The endothelium-dependent vasodilation, the blood flow velocity, the atherosclerotic lesion area, the serum levels of lipids, inflammatory cytokines and necroptosis-relevant proteins (RIPK1, RIPK3 and MLKL), and the endothelial necroptosis and apoptosis within the aorta wer...
Source: European Journal of Pharmacology - August 3, 2023 Category: Drugs & Pharmacology Authors: Li-Qun Lu Nian-Sheng Li Ming-Rui Li Jiao-Yang Peng Li-Jing Tang Xiu-Ju Luo Jun Peng Source Type: research
Regulators of phagocytosis as pharmacologic targets for stroke treatment
Stroke, including ischemic and hemorrhagic stroke, causes massive cell death in the brain, which is followed by secondary inflammatory injury initiated by disease-associated molecular patterns released from dead cells. Phagocytosis, a cellular process of engulfment and digestion of dead cells, promotes the resolution of inflammation and repair following stroke. However, professional or non-professional phagocytes also phagocytose stressed but viable cells in the brain or excessively phagocytose myelin sheaths or prune synapses, consequently exacerbating brain injury and impairing repair following stroke. Phagocytosis inclu...
Source: Frontiers in Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Source Type: research
As an inhibitor of norepinephrine release, dexmedetomidine provides no improvement on stroke-associated pneumonia in mice
Conclusion: The clinical use of DEX in stroke patients should be approached with caution, considering its inability to alleviate SAP symptoms and reduce the infarct area. Further research is necessary to fully understand the relationship between decreased CD3+ T cells and DEX’s influence on SAP.
Source: Frontiers in Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Source Type: research
Low-dose intravenous recombinant tissue plasminogen activator in acute ischemic stroke without large vessel occlusion screened by 3T MRI
CONCLUSIONS: Our study indicates the efficacy and safety of low-dose rTPA treatment for AIS without LVO within 4.5 hours. Patient selection for rTPA by 3T MRI decreased complications and mortality.PMID:37522667 | DOI:10.26355/eurrev_202307_33126
Source: Pharmacological Reviews - July 31, 2023 Category: Drugs & Pharmacology Authors: Q-S Huynh C-C Tran H-T Nguyen-Thi T-T Nguyen H-L Phan-Thi D-T Luu-Dang M-T Le M-D Nguyen Source Type: research
The identification of sex-specific biomarkers in peripheral blood mononuclear cells from elderly individuals with ischemic stroke
CONCLUSIONS: Ten genes for each sex with significant differential expression were also identified in individuals with IS. The novel sex-specific gene targets may be promising diagnostic or prognostic markers and potential therapeutic targets for IS in the elderly.PMID:37522661 | DOI:10.26355/eurrev_202307_33120
Source: Pharmacological Reviews - July 31, 2023 Category: Drugs & Pharmacology Authors: L-H Qin L Chen X Cao T-J Huang Z-Y Li S Li G-Z Wang Source Type: research
