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Total 689 results found since Jan 2013.

Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach
Gene. 2021 Jul 19;801:145856. doi: 10.1016/j.gene.2021.145856. Online ahead of print.ABSTRACTEpidemiological studies have established that untreated hypertension (HTN) is a major independent risk factor for developing cardiovascular diseases (CVD), stroke, renal failure, and other conditions. Several important studies have been published to prevent and manage HTN; however, antihypertensive agents' optimal choice remains controversial. Therefore, the present study is undertaken to update our knowledge in the primary treatment of HTN, specifically in the setting of other three important diseases. MicroRNAs (miRNAs) are remar...
Source: Gene - July 22, 2021 Category: Genetics & Stem Cells Authors: Kavita Sharma Prithvi Singh Md Amjad Beg Ravins Dohare Fareeda Athar Mansoor Ali Syed Source Type: research

Research Progress on Catalpol as Treatment for Atherosclerosis
Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide. Atherosclerosis (AS) is the most widespread underlying pathological change for the above diseases. Therefore, drugs that interfere with this pathophysiological process must be incorporated in the treatment. Chinese traditional and herbal drugs can effectively treat AS. With...
Source: Frontiers in Pharmacology - July 13, 2021 Category: Drugs & Pharmacology Source Type: research

The Protective Effect of Liquiritin in Hypoxia/Reoxygenation-Induced Disruption on Blood Brain Barrier
Conclusions: Studies have shown that LQ can promote cell proliferation, migration as well as angiogenesis, and reduce cell apoptosis, which may be related to its inhibition of oxidative and ER stress, and then maintain the integrity of BBB. Given that five differential proteins were found by protein analysis, future studies will revolve around the five differential proteins.
Source: Frontiers in Pharmacology - July 6, 2021 Category: Drugs & Pharmacology Source Type: research

Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study
In this study, XXMD was found to induce relaxation of the basilar artery rings of rats precontracted by 5-hydroxytryptamine (5-HT) in vitro, in a dose-dependent manner. The modulation of vascular tone and the process of cerebral ischemia are mediated via the interactions between G protein-coupled receptors (GPCRs) and their ligands, including 5-HT, angiotensin II (Ang II), and urotensin II (UII). Thus, the potential synergistic effects of the different components of XXMD on the regulation of vasoconstriction and vasodilation were further investigated by molecular docking based on network pharmacology. We constructed and an...
Source: Biomed Res - July 1, 2021 Category: Research Authors: Yanjia Shen Ran Yang Rui Zhou Wendan Lu Li Li Ziran Niu Miao Chen Jinhua Wang Yuehua Wang Lianhua Fang Guanhua Du Source Type: research

Janssen Submits New Drug Application to U.S. FDA for XARELTO ® (rivaroxaban) to Help Prevent and Treat Blood Clots in Pediatric Patients
RARITAN, NJ, June 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for the use of XARELTO® (rivaroxaban) in pediatric patients. The NDA seeks two pediatric indications: treatment of venous thromboembolism (VTE, or blood clots) and reduction in the risk of recurrent VTE in patients aged birth to less than 18 years of age after at least five days of initial parenteral anticoagulant treatment; and thromboprophylaxis (prevention of blood clots) in patients aged 2 years and older with congenita...
Source: Johnson and Johnson - June 23, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Quantitative and qualitative analyses of herbal medication use among Ghanaian stroke survivors
Herbal medicines are not regulated by regulatory authorities and are often not of proven safety and efficacy. Anecdotal reports suggest widespread use of traditional herbal medicine (THM) for treatment of stroke in Africa, but verifiable data are limited in published literature.
Source: Journal of the Neurological Sciences - June 12, 2021 Category: Neurology Authors: Fred Stephen Sarfo, Bruce Ovbiagele Tags: Clinical short communication Source Type: research

Herbal medicine for post-stroke insomnia: A protocol for systematic review and meta-analysis
Conclusion: This study will provide evidence regarding the efficacy and safety of HM for the treatment of PSI. Ethics and dissemination: No ethical approval will be needed because data from previously published studies in which informed consent was obtained by primary investigators will be retrieved and analyzed. We will publish this systematic review in a peer-reviewed journal. OSF registration DOI: 10.17605/OSF.IO/PEHQZ.
Source: Medicine - June 4, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Chinese Herbal Medicine Xingnaojing Injection for Acute Ischemic Stroke: An Overview of Systematic Reviews and Meta-Analyses
Conclusion: XNJ appears to be effective and safe for acute IS in improving the neurological deficits, but the evidence is not robust enough. However, whether administering XNJ immediately after or within 24 h of IS is best remains unknown due to the lack of data. Well-designed large-scale randomized controlled trials with measurable outcomes are required in future studies.
Source: Frontiers in Pharmacology - May 18, 2021 Category: Drugs & Pharmacology Source Type: research

Late-Breaking Data at ACC.21 Show XARELTO ® (rivaroxaban) Plus Aspirin Significantly Reduced Total Ischemic Events in Peripheral Artery Disease (PAD) Patients After Lower-Extremity Revascularization
RARITAN, N.J., May 16, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today presented new data from the Phase 3 VOYAGER PAD study which showed XARELTO® (rivaroxaban) (2.5 mg twice daily) in combination with aspirin (100 mg once daily) consistently reduced severe vascular events in patients with peripheral artery disease (PAD) after lower-extremity revascularization (LER) compared to aspirin alone regardless of whether it was the first, second, third, or subsequent event. The primary results of VOYAGER PAD showed that XARELTO® plus aspirin reduced first events by 15 percent among patients with PAD ...
Source: Johnson and Johnson - May 16, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Chinese Herbal Medicines and Active Metabolites: Potential Antioxidant Treatments for Atherosclerosis
Atherosclerosis is a complex chronic disease that occurs in the arterial wall. Oxidative stress plays a crucial role in the occurrence and progression of atherosclerotic plaques. The dominance of oxidative stress over antioxidative capacity generates excess reactive oxygen species, leading to dysfunctions of the endothelium and accelerating atherosclerotic plaque progression. Studies showed that Chinese herbal medicines and traditional Chinese medicine (TCM) might regulate oxidative stress; they have already been used to treat diseases related to atherosclerosis, including stroke and myocardial infarction. This review will...
Source: Frontiers in Pharmacology - May 13, 2021 Category: Drugs & Pharmacology Source Type: research

Mechanism of huoxue tongluo decoction in treatment of erectile dysfunction caused by ischemic stroke based on network pharmacology
Publication date: Available online 30 April 2021Source: Chinese Herbal MedicinesAuthor(s): Ji-sheng Wang, Heng-heng Dai, Kai-ge Zhang, Ke-gang Cao, Sheng Deng, Bing-hao Bao, Jun-long Feng, Fan-chao Meng, Hai-song Li, Bin Wang
Source: Chinese Herbal Medicines - April 30, 2021 Category: Complementary Medicine Source Type: research

Corrigendum to “Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats” Chinese Herbal Medicines 11 (2019) 45–51
Publication date: April 2021Source: Chinese Herbal Medicines, Volume 13, Issue 2Author(s): Wei-ting Wang, Chun-hua Hao, Shao-xiang Zhang, Xiang-hua Zhang, Feng Guo, Shuang-yong Sun, Rui Zhang, Zhuan-you Zhao, Li-da Tang
Source: Chinese Herbal Medicines - April 30, 2021 Category: Complementary Medicine Source Type: research

Disease Status –Dependent Drug–Herb Interactions: NASH Lowered the Risk of Hepatotoxicity in Rats Coadministered With Simvastatin and Gardenia jasminoides J. Ellis
Concurrent use of simvastatin (SV) and Gardenia jasminoides J. Ellis (GJ) was adopted in patients with multi-morbidity, such as stroke rehabilitation patients with NASH. Although hepatotoxicity has been reported in both of them and NASH could alter the pharmacokinetics of drugs/herbs, the interaction between SV and GJ and the related hepatotoxicity remained uninvestigated under neither healthy nor NASH condition. The current study aimed to evaluate the potential hepatotoxicity resulted from the interactions between SV and GJ in both healthy and NASH rats. Both healthy and NASH rats received two-week SV (p. o., 8.66 mg/kg,...
Source: Frontiers in Pharmacology - April 23, 2021 Category: Drugs & Pharmacology Source Type: research