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Effectiveness and safety of oral anticoagulants for non-valvular atrial fibrillation: a population-based cohort study in primary healthcare in Catalonia
Conclusion: Being men, a previous event and DOAC-switch posed a higher risk for all study outcomes. direct oral anticoagulants had a protective effect against cerebral bleeding in comparison to vitamin K antagonists. Adherence to direct oral anticoagulants resulted in lower risk of stroke and cerebral bleeding. We found no differences in the risk of stroke and gastrointestinal bleeding when we compared direct oral anticoagulants vs. vitamin K antagonists.
Source: Frontiers in Pharmacology - September 15, 2023 Category: Drugs & Pharmacology Source Type: research

Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and pathological changes. The brain, which has the highest oxygen consumption of any organ, is particularly susceptible to hypoxic injury. Exposure to low-pressure hypoxic environments can cause irreversible brain damage. Hypoxia can occur in healthy individuals at high altitudes or in pathological conditions such as trauma, stroke, inflammation, and autoimmune and neurodegenerative diseases, leading to severe brain damage and impairments in cognitive, learning, and memory functions. Exosomes may play a role in the ...
Source: Frontiers in Neurology - September 15, 2023 Category: Neurology Source Type: research

Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
ConclusionThese results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting S. aureus virulence factors for the prevention of staphylococcal septic shock.
Source: Frontiers in Immunology - September 15, 2023 Category: Allergy & Immunology Source Type: research

Applying neurointerventional expertise to save vision from eye strokes
Recent years have seen a dramatic change in the landscape of neurointerventional surgery, in large part due to the significant progress in the treatment of acute ischemic stroke (AIS). This progress has resulted in many thousands of lives saved and the prevention of life-changing morbidity and dependence in many more patients. Although the development of novel endovascular devices and procedural techniques was critical and arguably the ignition for these advances, as we move forward it is the integration of our systems of care and further collaboration with all stakeholders both within and away from the coal face clinical ...
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: De Leacy, R., Lema, G. M. C. Tags: Editor ' s column Source Type: research

Management of aneurysmal recurrence after Woven EndoBridge (WEB) treatment
Conclusion The retreatment rate after an initial WEB treatment seems to compare favorably with that of coiling. Endovascular treatment of recurrence following WEB implantation is feasible in most situations; it generally requires the use of a stent and leads to a high rate of satisfactory occlusion.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Caroff, J., Janot, K., Soize, S., Marnat, G., Cortese, J., Mihalea, C., Popescu, S. D., Ikka, L., Chalumeau, V., Gallas, S., Ozanne, A., Eltantawy, E., Grimaldi, L., Barreau, X., Herbreteau, D., Pierot, L., Spelle, L. Tags: Editor''s choice, Hemorrhagic stroke Source Type: research

Volumetric resolution of chronic subdural hematomas treated with surgical evacuation versus middle meningeal artery embolization during immediate, early, and late follow up: propensity-score matched cohorts
Conclusions In comparable cSDH patients, SEA resulted in better volumetric outcomes in immediate postoperative and early follow-up periods, as expected. However, this difference was not significant at more distant follow-up intervals. Furthermore, surgical patients experienced a significantly higher rate of recurrence.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Housley, S. B., Monteiro, A., Khawar, W. I., Donnelly, B. M., Lian, M. X., Fritz, A. G., Waqas, M., Cappuzzo, J. M., Snyder, K. V., Siddiqui, A. H., Levy, E. I., Davies, J. M. Tags: Hemorrhagic stroke Source Type: research

Direct puncture of the superior ophthalmic vein for carotid cavernous fistulas: a 21-year experience
Conclusion Direct SOV cannulation to treat CCFs is safe and effective. Although it is typically used after other endovascular approaches have failed, SOV access for CCF treatment may be warranted as a first-line treatment for select patients.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Catapano, J. S., Srinivasan, V. M., De La Pena, N. M., Singh, R., Cole, T. S., Wilkinson, D. A., Baranoski, J. F., Rutledge, C., Pacult, M. A., Winkler, E. A., Jadhav, A. P., Ducruet, A. F., Albuquerque, F. C. Tags: Hemorrhagic stroke Source Type: research

Single-antiplatelet regimen in ruptured cerebral blood blister and dissecting aneurysms treated with flow-diverter stent reconstruction
Conclusions Peri-interventional single-antiplatelet therapy with eptifibatide followed by prasugrel was sufficient to prevent thromboembolic events and reduce re-bleeding using an anti-thrombogenic FDS. FDS with single-antiplatelet therapy might be a viable option for ruptured blood blister and dissecting cerebral aneurysms.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Madjidyar, J., Keller, E., Winklhofer, S., Toth, D., Barnaure, I., Schubert, T., Thurner, P., Fierstra, J., Willms, J. F., Regli, L., Kulcsar, Z. Tags: Hemorrhagic stroke Source Type: research

Relationship between cerebral vasospasm vascular territory and functional outcome after aneurysmal subarachnoid hemorrhage
Conclusions In aneurysmal SAH, left-sided vasospasm is associated with worse discharge functional status. At 6 months, both ACA and BA vasospasm are associated with unfavorable functional status.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Cole, T. S., Rudy, R. F., Faridmoayer, E., Gandhi, S., Cavallo, C., Catapano, J. S., Jadhav, A. P., Lawton, M. T., Albuquerque, F. C., Ducruet, A. F. Tags: Hemorrhagic stroke Source Type: research

Reocclusion after successful endovascular treatment in acute ischemic stroke: systematic review and meta-analysis
Conclusion In cohorts of patients with AIS due to LVO, 5% of patients experienced reocclusion within 7 days after successful EVT. Repeated EVT can be a safe and effective treatment for selected patients with reocclusion.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Oliveira, R., Correia, M. A., Marto, J. P., Carvalho Dias, M., Mohamed, G. A., Nguyen, T. N., Nogueira, R. G., Aboul-Nour, H., Marin, H., Bou Chebl, A., Mohammaden, M. H., Al-Bayati, A. R., Haussen, D. C., Abdalkader, M., Fifi, J. T., Ortega-Gutierrez, S. Tags: Ischemic stroke Source Type: research

Type of intracranial hemorrhage after endovascular stroke treatment: association with functional outcome
Background Intracranial hemorrhage (ICH) is a frequent complication after endovascular stroke treatment. Objective To assess the association of the occurrence and type of ICH after endovascular treatment (EVT) with functional outcome. Methods We analyzed data from the MR CLEAN-NO IV and MR CLEAN-MED trials. Both trials included adult patients with ischemic stroke with a large vessel occlusion in the anterior circulation, who were eligible for EVT. ICH was classified (1) as asymptomatic or symptomatic (concomitant neurological deterioration of ≥4 points on the NIHSS, or ≥2 points on 1 NIHSS item), and (2) according ...
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: van der Steen, W., van der Ende, N. A. M., Luijten, S. P. R., Rinkel, L. A., van Kranendonk, K. R., van Voorst, H., Roosendaal, S. D., Beenen, L. F. M., Coutinho, J. M., Emmer, B. J., van Oostenbrugge, R. J., Majoie, C. B. L. M., Lingsma, H. F., van der L Tags: Open access, Ischemic stroke Source Type: research

Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial
Conclusions Our data showed that in the DIRECT-MT trial, alteplase did not increase overall ICH for large vessel occlusion patients treated with thrombectomy, but it increased the parenchymal hematoma rate.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Hu, X., Zhou, Y., Ospel, J., Yao, F., Liu, Y., Wang, H., Li, B., Hui, P., Yang, P., Zhang, Y., Zhang, L., Li, Z., Xing, P., Shi, H., Han, H., Wang, S., Fang, Q., Liu, J., for the Direct-MT investigators Tags: Open access, Ischemic stroke Source Type: research

Post-reperfusion hyperperfusion after endovascular stroke treatment: a prospective comparative study of TCD versus MRI
Conclusions TCD is a reliable bedside tool to identify post-reperfusion hyperperfusion, correlates well with perfusion MRI, and indicates risk of reperfusion injury after MT.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Kneihsl, M., Hinteregger, N., Nistl, O., Deutschmann, H., Horner, S., Poltrum, B., Fandler-Höfler, S., Hatab, I., Haidegger, M., Pinter, D., Pichler, A., Willeit, K., Knoflach, M., Enzinger, C., Gattringer, T. Tags: Ischemic stroke Source Type: research

Endovascular treatment of wide-necked intracranial aneurysms using the Nautilus Intrasaccular System: initial case series of 41 patients at a single center
Conclusion This study demonstrates good safety and effectiveness using the Nautilus Intrasaccular System to treat both ruptured and unruptured intracranial aneurysms. Larger studies are needed to confirm these findings.
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Sirakov, A., Bhogal, P., Sirakova, K., Penkov, M., Minkin, K., Ninov, K., Hristov, H., Hadzhiyanev, A., Karakostov, V., Sirakov, S. Tags: Open access, New devices New devices and techniques Source Type: research

Sensors, Vol. 23, Pages 7906: Quantitative Comparison of Hand Kinematics Measured with a Markerless Commercial Head-Mounted Display and a Marker-Based Motion Capture System in Stroke Survivors
Sofia Straudi Upper-limb paresis is common after stroke. An important tool to assess motor recovery is to use marker-based motion capture systems to measure the kinematic characteristics of patients’ movements in ecological scenarios. These systems are, however, very expensive and not readily available for many rehabilitation units. Here, we explored whether the markerless hand motion capabilities of the cost-effective Oculus Quest head-mounted display could be used to provide clinically meaningful measures. A total of 14 stroke patients executed ecologically relevant upper-limb tasks in an immersive vi...
Source: Sensors - September 15, 2023 Category: Biotechnology Authors: Antonino Casile Giulia Fregna Vittorio Boarini Chiara Paoluzzi Fabio Manfredini Nicola Lamberti Andrea Baroni Sofia Straudi Tags: Article Source Type: research