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Nutrition: Selenium

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Total 69 results found since Jan 2013.

Selenium attenuates ischemia/reperfusion injury ‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition
In conclusion, the present findings indicated that selenium can inhibit autophagy by regulating the PI3K/AKT/mTOR signaling pathway, significantly preventing BBB damage following cerebral I/R injury in hyperglycemic conditions.PMID:34296284 | DOI:10.3892/ijmm.2021.5011
Source: International Journal of Molecular Medicine - July 23, 2021 Category: Molecular Biology Authors: Biao Yang Yaqiong Li Yanmei Ma Xiaopeng Zhang Lan Yang Xilin Shen Jianzhong Zhang Li Jing Source Type: research

Characterization of Selenium Compounds for Anti-ferroptotic Activity in Neuronal Cells and After Cerebral Ischemia –Reperfusion Injury
AbstractThe emergence of ferroptosis as a cell death pathway associated with brain disorders including stroke and neurodegenerative diseases emphasizes the need to develop therapeutics able to target the brain and to protect neurons from ferroptotic death. Selenium plays an essential role in reducing lipid peroxidation generated during ferroptosis through its incorporation into the catalytic site of glutathione peroxidase 4. Here, we compared the anti-ferroptotic activity of several organic and inorganic selenium compounds: methylselenocysteine, selenocystine, selenomethionine, selenocystamine, ebselen, sodium selenite, an...
Source: Neurotherapeutics - September 8, 2021 Category: Neurology Source Type: research

Billions With Nutrition Deficiency!?
Almost no one gets enough selenium. Officially, at least a billion — with a B — people have a selenium deficiency.1 But I suspect the numbers are much higher than that. You can’t get enough selenium from food alone anymore. That’s true even if you eat a healthy, varied diet. And you can thank Big Agra for that. With their harsh pesticides, synthetic fertilizers, and single-crop strategy, these massive farms have stripped the nutrients out of the soil. No nutrients in the soil mean no nutrients in the food. All of this makes it difficult — if not impossible — to get even some of the daily selenium you need to ...
Source: Al Sears, MD Natural Remedies - May 15, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Nutrition Source Type: news

Selenium Treatment and Chagasic Cardiopathy (STCC): study protocol for a double-blind randomized controlled trial
DiscussionIf Se treatment reduces the progression of Chagas cardiopathy, the inclusion of this micronutrient in the daily diet can improve the therapeutic regimen for this neglected tropical disease at low cost.Trial registration: Clinical Trials.gov ID: NCT00875173 (registered 20 October 20 2008).
Source: Trials - October 6, 2014 Category: Journals (General) Authors: Pedro Alvarenga Americano do BrasilAndréa Pereira de SouzaAlejandro Hasslocher-MorenoSérgio XavierSonia Lambert PassosMaria de Fátima Ramos MoreiraMarília Santini de OliveiraGilberto Sperandio da SilvaRoberto Magalhães SaraivaClaudia Santos de Aguiar Source Type: research

Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine
Publication date: Available online 8 March 2018 Source:Aquatic Toxicology Author(s): Connor M. Pettem, Jennifer M. Briens, David M. Janz, Lynn P. Weber Selenium (Se) is considered as an essential trace element, involved in important physiological and metabolic functions for all vertebrate species. Fish require dietary concentrations of 0.1 to 0.5 μg Se/g dry mass (d.m.) to maintain normal physiological and selenoprotein function, however concentrations exceeding 3 μg/g d.m. have been shown to cause toxicity. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surroun...
Source: Aquatic Toxicology - March 9, 2018 Category: Toxicology Source Type: research

Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine.
Abstract Selenium (Se) is considered an essential trace element, involved in important physiological and metabolic functions for all vertebrate species. Fish require dietary concentrations of 0.1-0.5 μg Se/g dry mass (d.m.) to maintain normal physiological and selenoprotein function, however concentrations exceeding 3 μg/g d.m. have been shown to cause toxicity. As Se is reported to have a narrow margin between essentiality and toxicity, there is growing concern surrounding the adverse effects of elevated Se exposure caused by anthropogenic activities. Previous studies have reported that elevated dietary exp...
Source: Aquatic Toxicology - March 8, 2018 Category: Toxicology Authors: Pettem CM, Briens JM, Janz DM, Weber LP Tags: Aquat Toxicol Source Type: research

Investigation into the intracellular fates, speciation and mode of action of selenium-containing neuroprotective agents using XAS and XFM
Conclusions The differences in activity were thus attributed to the varied speciation and cellular localisation of the compounds, or their metabolites, as detected by X-ray absorption spectroscopy and X-ray fluorescence microscopy. Significance The work is significant as it links, for the first time, the protective action of selenium compounds against redox stress with particular chemical speciation using a direct measurement approach.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - April 8, 2018 Category: Biochemistry Source Type: research

Investigation into the intracellular fates, speciation and mode of action of selenium-containing neuroprotective agents using XAS and XFM.
CONCLUSIONS: The differences in activity were thus attributed to the varied speciation and cellular localisation of the compounds, or their metabolites, as detected by X-ray absorption spectroscopy and X-ray fluorescence microscopy. SIGNIFICANCE: The work is significant as it links, for the first time, the protective action of selenium compounds against redox stress with particular chemical speciation using a direct measurement approach. PMID: 29631056 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - April 6, 2018 Category: Biochemistry Authors: Wedding JL, Lai B, Vogt S, Harris HH Tags: Biochim Biophys Acta Source Type: research

Investigation into the intracellular fates, speciation and mode of action of selenium-containing neuroprotective agents using XAS and XFM
ConclusionsThe differences in activity were thus attributed to the varied speciation and cellular localisation of the compounds, or their metabolites, as detected by X-ray absorption spectroscopy and X-ray fluorescence microscopy.SignificanceThe work is significant as it links, for the first time, the protective action of selenium compounds against redox stress with particular chemical speciation using a direct measurement approach.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - July 5, 2018 Category: Biochemistry Source Type: research

A protocol update for the Selenium Treatment and Chagasic Cardiomyopathy (STCC) trial
Several studies evaluating clinical forms of chronic Chagas disease show that about one-third of patients present cardiac involvement. Heart failure, sudden death and cardioembolic stroke are the main mechanis...
Source: Trials - September 19, 2018 Category: General Medicine Authors: Marcelo Teixeira Holanda, Mauro Felippe Felix Mediano, Alejandro Marcel Hasslocher-Moreno, S érgio Salles Xavier, Roberto Magalhães Saraiva, Andrea Silvestre Sousa, Erica Rodrigues Maciel, Fernanda Martins Carneiro, Paula Simplicio da Silva, Luiz Henriq Tags: Update Source Type: research

A Nested Case–Control Study on Plasma Vitamin E and Risk of Cancer: Evidence of Effect Modification by Selenium
ConclusionsThis study suggests that higher levels of plasma vitamin E are associated with reduced risk of gastrointestinal cancer. High vitamin E decreased the risk of total cancer among patients with high selenium levels, but increased the risk of total cancer among those with low selenium levels.
Source: Journal of the Academy of Nutrition and Dietetics - February 1, 2019 Category: Nutrition Source Type: research