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Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats
Brain Res Bull. 2021 Feb 26:S0361-9230(21)00058-7. doi: 10.1016/j.brainresbull.2021.02.016. Online ahead of print.ABSTRACTThe deacetylase SIRT1 has been reported to play a critical role in regulating neurogenesis, which may be an adaptive processes contributing to recovery after stroke. Our previous work showed that the antioxidant capacity of Momordica charantia polysaccharides (MCPs) could protect against cerebral ischemia/reperfusion (I/R) after stroke. However, whether the protective effect of MCPs on I/R injury is related to NSCs proliferation remains unclear. In the present study, we designed in vivo and in vitro exp...
Source: Brain Research Bulletin - March 1, 2021 Category: Neurology Authors: Juyun Ma Haidi Fan Heng Cai Zhaoli Hu Xiaoling Zhou Fengying Li Hansen Chen Jiangang Shen Suhua Qi Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA ‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress.
Theaflavin attenuates cerebral ischemia/reperfusion injury by abolishing miRNA‑128‑3p‑mediated Nrf2 inhibition and reducing oxidative stress. Mol Med Rep. 2019 Oct 17;: Authors: Li R, Li X, Wu H, Yang Z, Fei L, Zhu J Abstract Theaflavin has been proven to own strong antioxidative capacity; however, the molecular mechanism underlying its protective effect against cerebral ischemia‑reperfusion (I/R) injury remains unclear. Therefore, the present study was designed to elucidate the neuroprotective effects of theaflavin on cerebral I/R injury and its underlying molecular mechanisms. To investigate ...
Source: Molecular Medicine Reports - October 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research