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The Role of Progranulin (PGRN) in the Pathogenesis of Ischemic Stroke
Cell Mol Neurobiol. 2023 Aug 10. doi: 10.1007/s10571-023-01396-8. Online ahead of print.ABSTRACTStroke is a life-threatening medical condition and is a leading cause of disability. Cerebral ischemia is characterized by a distinct inflammatory response starting with the production of various cytokines and other inflammation-related agents. Progranulin (PGRN), a multifunctional protein, is critical in diverse physiological reactions, such as cell proliferation, inflammation, wound healing, and nervous system development. A mature PGRN is anti-inflammatory, while granulin, its derivative, conversely induces pro-inflammatory c...
Source: Cellular and Molecular Neurobiology - August 10, 2023 Category: Cytology Authors: Daryush Purrahman Ali Shojaeian Łukasz A Poniatowski Bart łomiej Piechowski-Jóźwiak Mohammad-Reza Mahmoudian-Sani Source Type: research

Evaluating and Characterizing an Individually-Tailored Community Exercise Program for Older Adults With Chronic Neurological Conditions: A Mixed-Methods Study
J Aging Phys Act. 2022 Mar 16:1-14. doi: 10.1123/japa.2021-0292. Online ahead of print.ABSTRACTA mixed-methods approach was used to study an individually-tailored community exercise program for people with a range of chronic neurological conditions (e.g., stroke, spinal cord injury, brain injury, multiple sclerosis, Parkinson's disease) and abilities. The program was delivered to older adults (mean age: 62 ± 9 years) with chronic neurological conditions across a 12-week and an 8-week term. Participants attended 88% of sessions and completed 89% of prescribed exercises in those sessions. There were no adverse events. Clini...
Source: Journal of Aging and Physical Activity - March 16, 2022 Category: Geriatrics Authors: Vithusha Coomaran Ali Khan Erin Tyson Holly Bardutz Tristan D Hopper Cameron S Mang Source Type: research

Early and ultra-early surgical decompression for acute spinal cord injury: bracing for the winds of change
ConclusionThis is a call for hospital systems to swiftly restructure spinal services in order to meet the need for early, and possibly ultra-early, spinal decompression in aSCI cases in the near future.
Source: European Spine Journal - October 18, 2021 Category: Orthopaedics Source Type: research

Effects of task complexity or rate of motor imagery on motor learning in healthy young adults
ConclusionThis study supports the use of higher rates (75%) of motor imagery to improve motor learning. Additionally, the practice of a complex task demonstrated better motor learning in healthy young adults. Future longitudinal studies should validate these results in different patient's population such as stroke, spinal cord injury, and Parkinson's disease.
Source: Brain and Behavior - October 6, 2021 Category: Neurology Authors: Nargis Heena, Nayeem U. Zia, Stuti Sehgal, Shahnawaz Anwer, Ahmad Alghadir, Heng Li Tags: ORIGINAL RESEARCH Source Type: research

Sensors, Vol. 21, Pages 2084: Converging Robotic Technologies in Targeted Neural Rehabilitation: A Review of Emerging Solutions and Challenges
Astaras Recent advances in the field of neural rehabilitation, facilitated through technological innovation and improved neurophysiological knowledge of impaired motor control, have opened up new research directions. Such advances increase the relevance of existing interventions, as well as allow novel methodologies and technological synergies. New approaches attempt to partially overcome long-term disability caused by spinal cord injury, using either invasive bridging technologies or noninvasive human–machine interfaces. Muscular dystrophies benefit from electromyography and novel sensors that shed light on under...
Source: Sensors - March 16, 2021 Category: Biotechnology Authors: Nizamis Athanasiou Almpani Dimitrousis Astaras Tags: Review Source Type: research

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