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MassDevice.com +3 | The top 3 medtech stories for November 24, 2015
Say hello to MassDevice +3, a bite-sized view of the top three medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 3 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry.   3. Ocular Therapeutix launches another pivotal for Dextenza eye drug-device combo Ocular Therapeutix said today that it launched another pivotal trial for its Dextenza drug-device combination, its 2nd study of the treatment for an allergic conjunctivitis indication. Bedford, Mass.-based Ocular Th...
Source: Mass Device - November 24, 2015 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 3 Source Type: news

Association between Demographic Characteristics and Hospital Admission in Patients Presenting to the Emergency Department for Transient Neurological Attack (P6.277)
Conclusions:Among patients presenting to the ED with TNA, female sex and race are associated with decreased odds of admission, even after adjusting for socioeconomic and vascular risk factors. Further studies are warranted to determine the public health impact of our results.Disclosure: Dr. Kummer has nothing to disclose. Dr. Parikh has nothing to disclose. Dr. Merkler has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel has received personal compensation in an editorial capacity for Journal Watch Neurology.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Kummer, B., Parikh, N., Merkler, A., Kamel, H. Tags: Cerebrovascular Disease Health Services Research Source Type: research

The Effect of Health Care Disparities on Complications and Mortality in Sickle Cell Disease
Discussion:The data indicates that the rate of complications from SCD have risen since 1999. With newer therapies and better understanding, the life expectancy of SCD patients has risen over time, nearly doubling from 1951 to 2018. The increased frequency of complications may be attributed to better survivorship and a rising number of older SCDs patients. However, our data also suggests that insurance status plays a significant role in the complication rate of SCD. The uninsured and patients with Medicaid have significantly increased risk of developing disease complications and resultant mortality. This could be the result...
Source: Blood - November 21, 2018 Category: Hematology Authors: Perimbeti, S. P., Hou, K. Y., Ramanathan, S., Woodard, A., Kyung, D., Wang, Q., Crilley, P. A., Ward, K., Styler, M. Tags: 903. Outcomes Research-Non-Malignant Hematology Source Type: research

Brief Report: Integrase Strand Transfer Inhibitors Are Associated With Lower Risk of Incident Cardiovascular Disease in People Living With HIV
Conclusion: In this cohort, INSTI-based regimens were associated with a 21% decreased risk of incident cardiovascular disease. These finding require validation in other cohorts and with longer follow-up.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - June 25, 2020 Category: Infectious Diseases Tags: Clinical Science Source Type: research

FDA Approves Lecanemab, a New Alzheimer ’s Drug
On Jan. 6, the U.S. Food and Drug Administration (FDA) approved a new drug to treat Alzheimer’s disease in its early stages. Lecanemab, which will be available under the name Leqembi, can slow the cognitive decline associated with Alzheimer’s disease by 27%, according to data submitted to the FDA by the drug’s developers, Eisai and Biogen. It’s only the second medication to show any improvement in neurodegeneration, a key criterion in the FDA’s consideration for approval. “For a long time, this is what we have been looking for,” says Dr. Sam Gandy, professor of neurology and psychi...
Source: TIME: Health - January 6, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Drugs healthscienceclimate Source Type: news

Age‐related treatment patterns in sickle cell disease patients and the associated sickle cell complications and healthcare costs
ConclusionsPatients transitioning to adult care received less transfusions and hydroxyurea, less ICT when eligible for chelation therapy, had higher healthcare costs and suffered from more frequent SCD related complications than pediatric patients. These findings highlight the changes in treatment patterns corresponding to transition to adult care. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - January 17, 2013 Category: Cancer & Oncology Authors: Morey A. Blinder, Francis Vekeman, Medha Sasane, Alex Trahey, Carole Paley, Mei Sheng Duh Tags: Research Article Source Type: research

National utilization patterns of warfarin use in older patients with atrial fibrillation: a population-based study of Medicare Part D beneficiaries
Source: Annals of Pharmacotherapy Area: Evidence > Medicines Management > References Background: Although warfarin therapy reduces stroke incidence in patients with atrial fibrillation (AF), the rate of warfarin use in this population remains low.  In 2008, the US Medicare Part D programme was expanded to pay for medications for Medicare enrollees. Objective: To examine rates and predictors of warfarin use in Medicare Part D beneficiaries with AF. Methods: This population-based retrospective cohort study used claims data from 41,447 Medicare beneficiaries aged 66 and older with at least 2 AF diagnoses in ...
Source: NeLM - Cardiovascular Medicine - January 24, 2013 Category: Cardiology Source Type: news

Abstract 150: Resource Utilization Patterns and Outcomes Among Acute Coronary Syndrome Patients: Findings From a Multi-Payer Analysis Poster Session II
Conclusion: These findings suggest that many patients with ACS do not receive appropriate recommended antithrombotic prophylaxis, and opportunities exist to improve therapy. Increased use of software tools such as AQuA may support enhanced education efforts aimed at improving adherence to guidelines and quality of care.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Lang, K., Bozkaya, D., Patel, A. A., Macomson, B., Crivera, C., Owens, G., Mody, S. Tags: Poster Session II Source Type: research

Clinical correlates of obesity in an inner-city adult medicine clinic.
In conclusion, obesity was associated with many diseases, as well as with healthcare utilization, unemployment and disability in this predominantly minority inner-city population. PMID: 23691735 [PubMed - in process]
Source: Connecticut Medicine - April 1, 2013 Category: Journals (General) Authors: Yassir S, Chopra R, Roush G Tags: Conn Med Source Type: research

Routine revascularization is unnecessary in the majority of patients requiring zone II coverage during thoracic endovascular aortic repair: A longitudinal outcomes study using United States Medicare population data.
ConclusionsTEVAR + SUB were associated with lower rates of mortality and complications. Only a small percentage of TEVAR + SUB required a bypass at one year after procedure. Our data suggest that routine LSA bypass during TEVAR is unnecessary and associated with increase morbidity and mortality. PMID: 24003009 [PubMed - as supplied by publisher]
Source: Vascular - September 3, 2013 Category: Surgery Authors: Wilson JE, Galiñanes EL, Hu P, Dombrovskiy VY, Vogel TR Tags: Vascular Source Type: research

The impact of regulatory approval and medicare coverage on outcomes of carotid stenting
CONCLUSIONS Declines in peri‐procedural DS rates in CAS appear linked to regulatory and coverage approvals leading to increased operator experience along with continued regulatory oversight, and provide insight into the introduction of other novel therapies. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - November 12, 2013 Category: Cardiovascular & Thoracic Surgery Authors: William A. Gray, Patrick Verta Tags: Original Study Source Type: research

Comparison of Systemic Health Conditions between African American and Caucasian Complete Denture Patients
ConclusionsAmong selected completely edentulous denture patients at an urban dental school, two out of three patients had at least one SHC. This exploratory study suggests there may be health status differences between African American and Caucasian patients in this setting, calling for further study.
Source: Journal of Prosthodontics - January 13, 2014 Category: Dentistry Authors: Ewelina Szylkowska, Linda M. Kaste, Joseph Schreiner, Sara C. Gordon, Damian J. Lee Tags: Original Article Source Type: research

Assessing Providers Antipsychotics Prescription Habits in Long Term Care: A QI Study
Inappropriate use of antipsychotics is associated with increased adverse outcomes of death, heart attack, stroke, falls, and hospitalizations. The national goal established by Center for Medicare & Medicaid Services (CMS) is to reduce the percentage of long-stay nursing home residents who receive antipsychotic medications by 15% per year. Using the CMS quality measure based on Minimum Data Set (MDS) 3.0 shows that at Mayo's teaching nursing home (Samaritan Bethany) 10.2% residents were on antipsychotics in the last quarter of 2012 and 12.1% in the first quarter of 2013.
Source: Journal of the American Medical Directors Association - February 10, 2014 Category: Health Management Authors: Sandeep R. Pagali, Sandeep R. Pagali, Brandon P. Verdoorn, Eric G. Tangalos Tags: Poster Abstracts Source Type: research

Abstract 20: Public Reporting of Mortality Rates for Cardiovascular Conditions Did Not Improve Patient Outcomes Session Title: Concurrent II Session A: Oral Abstracts on Policy Issues
Conclusions: We found that mortality rates for publicly reported conditions were improving slightly during the period when only processes of care were being reported, but that these improvements slowed or reversed once public reporting of mortality rates began. These findings suggest that public reporting may be necessary, but is clearly not sufficient, to improve patient outcomes.
Source: Circulation: Cardiovascular Quality and Outcomes - June 2, 2014 Category: Cardiology Authors: Joynt, K. E., Orav, E. J., Jha, A. K. Tags: Session Title: Concurrent II Session A: Oral Abstracts on Policy Issues Source Type: research

Health Insurance and Chronic Conditions in Low-Income Urban Whites
This study uses cross-sectional data on 491 low-income urban non-elderly non-Hispanic whites from the Exploring Health Disparities in Integrated Communities—Southwest Baltimore (EHDIC-SWB) study to examine the relationship between insurance status and chronic conditions (defined as participant report of ever being told by a doctor they had hypertension, diabetes, stroke, heart attack, anxiety or depression, asthma or emphysema, or cancer). In this sample, 45.8 % were uninsured, 28.3 % were publicly insured, and 25.9 % had private insurance. Insured participants had similar odds of having any chronic condition (odds ra...
Source: Journal of Urban Health - August 1, 2014 Category: Health Management Source Type: research