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Condition: Hemorrhagic Stroke
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Rationale and design of the PreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage (PICASSO) study: A randomized controlled trial
DiscussionPreventIon of CArdiovascular events in iSchemic Stroke patients with high risk of cerebral hemOrrhage is the largest secondary stroke prevention trial for informing antiplatelet therapy and lipid management in patients at high risk of haemorrhagic stroke.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Keun‐Sik Hong, Bum Joon Kim, Jun‐Young Lee, Sun U. Kwon, Tags: Protocol Source Type: research

Intakes of magnesium, potassium, and calcium and the risk of stroke among men
ConclusionsA diet rich in magnesium, potassium, and calcium may contribute to reduced risk of stroke among men. Because of significant collinearity, the independent contribution of each cation is difficult to define.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Sally N. Adebamowo, Donna Spiegelman, Alan J. Flint, Walter C. Willett, Kathryn M. Rexrode Tags: Research Source Type: research

Temporal relationship between infective endocarditis and stroke
Conclusions: The association between IE and stroke persists for longer than previously reported. Most diagnoses of stroke and IE are made close together in time, but a period of heightened stroke risk becomes apparent several months before the diagnosis of IE and lasts for several months afterward.
Source: Neurology - August 10, 2015 Category: Neurology Authors: Merkler, A. E., Chu, S. Y., Lerario, M. P., Navi, B. B., Kamel, H. Tags: All Cerebrovascular disease/Stroke, Cohort studies, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Blood Pressure Control and Risk of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: Results From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial Stroke
Conclusions High BP measurement at any point during the trial was independently associated with a substantially higher risk of stroke or systemic embolism. These results strongly support efforts to treat elevated BP as an important strategy to optimally lower risk of stroke in patients with AF. Clinical Trial Registration URL: https://ClinicalTrials.gov/. Unique identifier: NCT00412984.
Source: JAHA:Journal of the American Heart Association - December 1, 2015 Category: Cardiology Authors: Rao, M. P., Halvorsen, S., Wojdyla, D., Thomas, L., Alexander, J. H., Hylek, E. M., Hanna, M., Bahit, M. C., Lopes, R. D., De Caterina, R., Erol, C., Goto, S., Lanas, F., Lewis, B. S., Husted, S., Gersh, B. J., Wallentin, L., Granger, C. B., the Apixaban Tags: Stroke Source Type: research

Increased Risk of Cerebrovascular Disease Among Patients With Neurofibromatosis Type 1: Population-Based Approach Clinical Sciences
Conclusions— When compared with the general population, the odds of any type of stroke are significantly increased for patients with NF1, both adult and pediatric. This risk is most notable for hemorrhagic strokes although it is also increased for ischemic strokes in children. Physicians should be aware of the increased risk of stroke in this population, and consider stroke as a potential cause of new neurological symptoms.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Terry, A. R., Jordan, J. T., Schwamm, L., Plotkin, S. R. Tags: Clinical Studies, Cerebrovascular Disease/Stroke, Cerebrovascular Malformations, Moyamoya Clinical Sciences Source Type: research

Multiple Myeloma Stage I, II and Renal Insufficiency Are Associated with Increased Stroke Risk (S31.003)
Conclusion: In multiple myeloma,patient’s renal insufficiency and MM Stage I and II were independent predictors of increased stroke risk. Besides these hypercoagulability, atrial fibrillation, watershed strokes and small vessel disease played important role.Disclosure: Dr. Limaye has nothing to disclose. Dr. Ravilla has nothing to disclose. Dr. Appalnaidu has nothing to disclose. Dr. Papanikolaou has nothing to disclose. Dr. Waheed has nothing to disclose. Dr. Hinduja has nothing to disclose.
Source: Neurology - February 7, 2016 Category: Neurology Authors: Limaye, K., Ravilla, R., Sasapu, A., Papanikolaou, X., Waheed, S., Hinduja, A. Tags: Stroke Risk, Outcomes, and Complications Source Type: research

Lifetime direct costs of stroke for indigenous patients adjusted for comorbidities
Conclusions: The costs of stroke for indigenous people and patients with different comorbidities are substantial and an integrated prevention strategy is needed.
Source: Neurology - July 31, 2016 Category: Neurology Authors: Zhao, Y., Condon, J., Lawton, P., He, V., Cadilhac, D. A. Tags: Cost effectiveness/economic, All Cerebrovascular disease/Stroke, Cohort studies ARTICLE Source Type: research

Interleukin-37 is Elevated in Acute Ischemic Stroke (P1.260)
Conclusions:The study shows a rather stable elevation of IL-37 levels post-ischemic stroke, which if compared to available data from other studies, is 3–10 times elevated after acute ischemic stroke with an uptrend in the first few days. IL-37 plays some role in mediating post-stroke inflammation with significant rise in serum and urine IL- 37 levels suggesting a key role of this novel cytokine in post-stroke pathology.Disclosure: Dr. Bushnaq has nothing to disclose. Dr. Zafar has nothing to disclose. Dr. Duraisamy has nothing to disclose. Dr. Tasneem has nothing to disclose. Dr. Khan has nothing to disclose. Dr. Lei...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Bushnaq, S., Zafar, A., Duraisamy, K., Tasneem, N., Khan, M., Leira, E., Zaheer, A. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Incidence of Stroke in the US Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) Cohort (S51.008)
Conclusions:In this large study of neurologist adjudicated stroke in a HIV cohort, the AS stroke incidence rate was 337.7. The stroke rate was higher in women, African-Americans and older ages. These incidence data, combined with additional risk factor analyses, and comparisons with non-HIV cohorts, will allow better understanding of stroke in HIV, with the ultimate goal of improved outcomes.Study Supported by: NIAID, NHLBI (5R24AI067039) and AHA (13GRNT14560022)Disclosure: Dr. Tirschwell has received research support from St. Jude Medical and Bayer. Dr. Chow has nothing to disclose. Dr. Becker has received personal compen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tirschwell, D., Chow, F., Becker, K., Marra, C., Zunt, J., Ho, E., Kalani, R., Huffer, A., Nance, R., Williams-Nguyen, J., Burkholder, G., Moore, R., Mathews, W., Eron, J., Drozd, D., Kitahata, M., Saag, M., Crane, H. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Probable REM sleep behavior disorder and risk of stroke: A prospective study
Conclusions: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Ma, C., Pavlova, M., Liu, Y., Liu, Y., Huangfu, C., Wu, S., Gao, X. Tags: All Cerebrovascular disease/Stroke, All Sleep Disorders, Cohort studies ARTICLE Source Type: research

Biomarker Application for Precision Medicine in Stroke
AbstractStroke remains one of the leading causes of long-term disability and mortality despite recent advances in acute thrombolytic therapies. In fact, the global lifetime risk of stroke in adults over the age of 25 is approximately 25%, with 24.9 million cases of ischemic stroke and 18.7 million cases of hemorrhagic stroke reported in 2015. One of the main challenges in developing effective new acute therapeutics and enhanced long-term interventions for stroke recovery is the heterogeneity of stroke, including etiology, comorbidities, and lifestyle factors that uniquely affect each individual stroke survivor. In this com...
Source: Translational Stroke Research - December 17, 2019 Category: Neurology Source Type: research

Multicentre collection of uniform data on patients hospitalised for transient ischaemic attack or stroke in the Philippines: the Philippine Neurological Association One Database-Stroke (PNA1DB-Stroke) protocol
Introduction For scientific advances to translate into improved patient outcomes, systems of care must be in place to facilitate delivery of care. There is scarce information on quality of care and clinical outcome in our stroke patients. We aim to collect uniform data from patients with first or recurrent transient ischaemic attack (TIA) or ischaemic or haemorrhagic stroke to determine in-patient caseload, patient profile, types of diagnostic and therapeutic procedures, outcomes and overall quality of care among patients hospitalised for acute stroke in the Philippines. Methods and analysis This multicentre observational...
Source: BMJ Open - May 24, 2022 Category: General Medicine Authors: Philippine Neurological Association One Database - Stroke, Disease Study Management Group, Gan, Alvarez, Canete, Co, Collantes, Escabillas, Hiyadan, Juangco, Lokin, Macrohon-Valdez, Punsalan, Sarapuddin, Picar, Pascual V Tags: Open access, Neurology Source Type: research

Stroke incidence and 30‐day and six‐month case fatality rates in Udine, Italy: a population‐based prospective study
ConclusionsOur study shows incidence rates higher than previously reported in our region but not supporting the view of higher incidence rates in Northern than in Southern Italy. Results contribute to time‐trends analysis on epidemiology, useful for dimensioning services in Italy and show the persistence of a gap between the outcome of stroke in Italy and that of the best performing European countries, urging to adopt better stroke management plans.
Source: International Journal of Stroke - March 21, 2013 Category: Neurology Authors: Francesco Janes, Gian Luigi Gigli, Lucio D'Anna, Iacopo Cancelli, Anna Perelli, Giessica Canal, Valentina Russo, Barbara Zanchettin, Mariarosaria Valente Tags: Research Source Type: research

Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): Protocol for a randomized, placebo‐controlled, double‐blind clinical trial to assess the effect of high‐dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36·5°C or above
DiscussionIf high‐dose paracetamol will be proven effective, a simple, safe, and extremely cheap therapy will be available for many patients with acute stroke worldwide.
Source: International Journal of Stroke - May 22, 2013 Category: Neurology Authors: Inger R. Ridder, Frank Jan Jong, Heleen M. Hertog, Hester F. Lingsma, H. Maarten A. Gemert, A. H. C. M. L. (Tobien) Schreuder, Annemieke Ruitenberg, E. (Lisette) Maasland, Ritu Saxena, Peter Oomes, Jordie Tuijl, Peter J. Koudstaal, L. Jaap Kappelle, Ale A Tags: Protocols Source Type: research

Thrombolysis Despite Recent Stroke: A Case Series Brief Reports
Conclusions— In our center, we thrombolysed 6 patients despite recent stroke. Three patients had asymptomatic petechial hemorrhagic transformation within the area of subacute infarct, without apparent neurological worsening. Prospective studies are needed to explore the possible safety of tissue-type plasminogen activator in the context of previous subacute stroke in otherwise eligible patients.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Alhazzaa, M., Sharma, M., Blacquiere, D., Stotts, G., Hogan, M., Dowlatshahi, D. Tags: Acute Cerebral Infarction, Thrombolysis Brief Reports Source Type: research