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Condition: Hemorrhagic Stroke
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Total 12507 results found since Jan 2013.

Systolic Blood Pressure After Intravenous Antihypertensive Treatment and Clinical Outcomes in Hyperacute Intracerebral Hemorrhage: The Stroke Acute Management With Urgent Risk-Factor Assessment and Improvement-Intracerebral Hemorrhage Study Clinical Sciences
Conclusions— High achieved SBP after standardized antihypertensive therapy in hyperacute intracerebral hemorrhage was independently associated with poor clinical outcomes. Aggressive antihypertensive treatment may ameliorate clinical outcomes.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Sakamoto, Y., Koga, M., Yamagami, H., Okuda, S., Okada, Y., Kimura, K., Shiokawa, Y., Nakagawara, J., Furui, E., Hasegawa, Y., Kario, K., Arihiro, S., Sato, S., Kobayashi, J., Tanaka, E., Nagatsuka, K., Minematsu, K., Toyoda, K., for the SAMURAI Study Inv Tags: Cerebrovascular disease/stroke, CT and MRI, Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Prospective, Multicenter, Single-Arm Study of Mechanical Thrombectomy Using Solitaire Flow Restoration in Acute Ischemic Stroke Clinical Sciences
Conclusions— In this single-arm study, treatment with the Solitaire Flow Restoration device in intracranial anterior circulation occlusions results in high rates of revascularization, low risk of clinically relevant procedural complications, and good clinical outcomes in combination with low mortality at 90 days. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01327989.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Pereira, V. M., Gralla, J., Davalos, A., Bonafe, A., Castano, C., Chapot, R., Liebeskind, D. S., Nogueira, R. G., Arnold, M., Sztajzel, R., Liebig, T., Goyal, M., Besselmann, M., Moreno, A., Schroth, G. Tags: Emergency treatment of Stroke Clinical Sciences Source Type: research

THRIVE Score Predicts Ischemic Stroke Outcomes and Thrombolytic Hemorrhage Risk in VISTA Clinical Sciences
Conclusions— The THRIVE score is a simple-to-use tool to predict clinical outcome, mortality, and risk of hemorrhage after thrombolysis in patients with ischemic stroke. Despite its simplicity, the THRIVE score performs better than several other outcome prediction tools. A free Web calculator for the THRIVE score is available at http://www.thrivescore.org.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Flint, A. C., Faigeles, B. S., Cullen, S. P., Kamel, H., Rao, V. A., Gupta, R., Smith, W. S., Bath, P. M., Donnan, G. A., on behalf of the VISTA Collaboration, VISTA Steering Committee (VISTA-Acute) members, Lees, Alexandrov, Bath, Bluhmki, Bornstein, Cla Tags: Emergency treatment of Stroke Clinical Sciences Source Type: research

CLOTBUST-Hands Free: Pilot Safety Study of a Novel Operator-Independent Ultrasound Device in Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Sonothrombolysis using a novel, operator-independent device, in combination with systemic tPA, seems safe, and recanalization rates warrant evaluation in a phase III efficacy trial. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: CLOTBUST-HF NCT01240356.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Barreto, A. D., Alexandrov, A. V., Shen, L., Sisson, A., Bursaw, A. W., Sahota, P., Peng, H., Ardjomand-Hessabi, M., Pandurengan, R., Rahbar, M. H., Barlinn, K., Indupuru, H., Gonzales, N. R., Savitz, S. I., Grotta, J. C. Tags: Acute Cerebral Infarction, Doppler ultrasound, Transcranial Doppler etc., Thrombolysis, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Impact of Pretreatment Noncontrast CT Alberta Stroke Program Early CT Score on Clinical Outcome After Intra-Arterial Stroke Therapy Clinical Sciences
Conclusions— NCCT seems useful for excluding patients with the greatest burden of ischemic damage from futile intra-arterial treatment, which is unlikely to result in patient functional independence and increases the risk of hemorrhage.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Yoo, A. J., Zaidat, O. O., Chaudhry, Z. A., Berkhemer, O. A., Gonzalez, R. G., Goyal, M., Demchuk, A. M., Menon, B. K., Mualem, E., Ueda, D., Buell, H., Sit, S. P., Bose, A., on behalf of the Penumbra Pivotal and Penumbra Imaging Collaborative Study (PICS Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research

Different Doses of Recombinant Tissue-Type Plasminogen Activator for Acute Stroke in Chinese Patients Clinical Sciences
Conclusions— These results did not support the dose of 0.9 mg/kg of r-tPA being optimal for all patients in the East Asian population. In elderly patients (71–80 years), a lower dose of 0.6 mg/kg is associated with a better outcome. Confirmation of the results through randomized trial is required.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Chao, A.-C., Liu, C.-K., Chen, C.-H., Lin, H.-J., Liu, C.-H., Jeng, J.-S., Hu, C.-J., Chung, C.-P., Hsu, H.-Y., Sheng, W.-Y., Hu, H.-H., on behalf of the Taiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group Tags: Thrombolysis Clinical Sciences Source Type: research

Influence of Age on Clinical and Revascularization Outcomes in the North American Solitaire Stent-Retriever Acute Stroke Registry Clinical Sciences
Conclusion— Greater than 80 years of age is predictive of poor clinical outcome and increased mortality compared with younger patients in the NASA registry. However, intravenous tissue-type plasminogen activator use, lower NIHSS, and shorter revascularization time are associated with better outcomes. Further studies are needed to understand the endovascular therapy role in this cohort compared with medical therapy.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Castonguay, A. C., Zaidat, O. O., Novakovic, R., Nguyen, T. N., Taqi, M. A., Gupta, R., Sun, C.-H. J., Martin, C., Holloway, W. E., Mueller-Kronast, N., E. English, J., Linfante, I., Dabus, G., Malisch, T. W., Marden, F. A., Bozorgchami, H., Xavier, A., R Tags: Acute Cerebral Infarction, Emergency treatment of Stroke Clinical Sciences Source Type: research

Relevance of Blood-Brain Barrier Disruption After Endovascular Treatment of Ischemic Stroke: Dual-Energy Computed Tomographic Study Clinical Sciences
Conclusions— Blood–brain barrier disruption, defined as CS and BH on dual-energy CT, was associated with poor clinical outcomes in patients with stroke treated with endovascular therapies. Moreover, isolated CS was associated with delayed hemorrhagic transformation. These results support the clinical relevance of blood–brain barrier disruption in acute stroke.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Renu, A., Amaro, S., Laredo, C., Roman, L. S., Llull, L., Lopez, A., Urra, X., Blasco, J., Oleaga, L., Chamorro, A. Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging, Thrombolysis Clinical Sciences Source Type: research

Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke Trial Clinical Sciences
Conclusions— These results demonstrate comparable safety of full-dose r-tPA plus eptifibatide with historical rates of sICH with r-tPA alone and support proceeding with a phase 3 trial evaluating full-dose r-tPA combined with eptifibatide to improve outcomes after AIS.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Adeoye, O., Sucharew, H., Khoury, J., Vagal, A., Schmit, P. A., Ewing, I., Levine, S. R., Demel, S., Eckerle, B., Katz, B., Kleindorfer, D., Stettler, B., Woo, D., Khatri, P., Broderick, J. P., Pancioli, A. M. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Coagulation and Fibrinolytic Activity of Tenecteplase and Alteplase in Acute Ischemic Stroke Brief Reports
Conclusions— In patients with acute ischemic stroke, alteplase 0.9 mg/kg caused significant disruption of the fibrinolytic system, whereas tenecteplase 0.25 mg/kg did not, consistent with the trend toward lower intracerebral hemorrhage incidence with tenecteplase in the ATTEST study. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01472926.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Huang, X., Moreton, F. C., Kalladka, D., Cheripelli, B. K., MacIsaac, R., Tait, R. C., Muir, K. W. Tags: Treatment, Ischemic Stroke, Thrombosis Brief Reports Source Type: research

Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis Clinical Sciences
Conclusions— In patients with intracerebral hemorrhage within 48 hours of onset, GTN lowered blood pressure was safe but did not improve functional outcome. Very early treatment might be beneficial but needs assessment in further studies. Clinical Trial Registration— URL: http://www.isrctn.com/ISRCTN99414122. Unique identifier: 99414122.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Krishnan, K., Scutt, P., Woodhouse, L., Adami, A., Becker, J. L., Berge, E., Cala, L. A., Casado, A. M., Caso, V., Chen, C., Christensen, H., Collins, R., Czlonkowska, A., Dineen, R. A., Gommans, J., Koumellis, P., Lees, K. R., Ntaios, G., Ozturk, S., Phi Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Intracranial Hemorrhage Clinical Sciences Source Type: research

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke Brief Report
Conclusions—Our results demonstrate TLR4 involvement in hemorrhagic transformation induced by delayed tPA administration, very likely by increasing matrix metalloproteinase 9 expression.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Alicia Garcia–Culebras, Sara Palma–Tortosa, Ana Moraga, Isaac Garcia–Yebenes, Violeta Duran–Laforet, Maria I. Cuartero, Juan de la Parra, Ana L. Barrios–Munoz, Jaime Diaz–Guzman, Jesus M. Pradillo, Maria A. Moro, Ignaci Tags: Blood-Brain Barrier, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Influence of Renal Impairment on Outcome for Thrombolysis-Treated Acute Ischemic Stroke Brief Report
Background and Purpose—Renal dysfunction (RD) is associated with poor prognosis after stroke. We assessed the effects of RD on outcomes and interaction with low- versus standard-dose alteplase in a post hoc subgroup analysis of the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study).Methods—A total of 3220 thrombolysis-eligible patients with acute ischemic stroke (mean age, 66.5 years; 37.8% women) were randomly assigned to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) intravenous alteplase within 4.5 hours of symptom onset. Six hundred and fifty-nine (19.8%) patients had moderate-to-severe R...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Susan J. Carr, Xia Wang, Veronica V. Olavarria, Pablo M. Lavados, Jorge A. Rodriguez, Jong S. Kim, Tsong-Hai Lee, Richard I. Lindley, Octavio M. Pontes-Neto, Stefano Ricci, Shoichiro Sato, Vijay K. Sharma, Mark Woodward, John Chalmers, Craig S. Anderson, Tags: Clinical Studies, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease Brief Report
Background and Purpose—There is growing evidence about the importance of vitamin D for cardiovascular health. Therefore, we examined the relationship between dietary vitamin D intake and risk of mortality from stroke and coronary heart disease in Japanese population.Methods—A prospective study encompassing 58 646 healthy Japanese adults (23 099 men and 35 547 women) aged of 40 to 79 years in whom dietary vitamin D intake was determined via a self-administered food frequency questionnaire. The median follow-up period was 19.3 years (1989–2009). The hazard ratios and 95% confidence intervals of mortality were calcu...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Haytham A. Sheerah, Ehab S. Eshak, Renzhe Cui, Hironori Imano, Hiroyasu Iso, Akiko Tamakoshi Tags: Cardiovascular Disease, Diet and Nutrition, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Anxiety After Stroke Clinical Sciences
Background and Purpose—Anxiety after stroke is common and disabling. Stroke trialists have treated anxiety as a homogenous condition, and intervention studies have followed suit, neglecting the different treatment approaches for phobic and generalized anxiety. Using diagnostic psychiatric interviews, we aimed to report the frequency of phobic and generalized anxiety, phobic avoidance, predictors of anxiety, and patient outcomes at 3 months poststroke/transient ischemic attack.Methods—We followed prospectively a cohort of new diagnosis of stroke/transient ischemic attack at 3 months with a telephone semistructured psych...
Source: Stroke - February 26, 2018 Category: Neurology Authors: Ho-Yan Yvonne Chun, William N. Whiteley, Martin S. Dennis, Gillian E. Mead, Alan J. Carson Tags: Mental Health, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research