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Condition: Ischemic Stroke
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Total 40393 results found since Jan 2013.

Early Insulin Glycemic Control Combined With tPA Thrombolysis Reduces Acute Brain Tissue Damages in a Focal Embolic Stroke Model of Diabetic Rats Brief Reports
Conclusions— Early insulin glycemic control may be beneficial in combination with tPA thrombolysis for ischemic stroke with diabetes mellitus or poststroke hyperglycemia.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Fan, X., Ning, M., Lo, E. H., Wang, X. Tags: Animal models of human disease, Type 1 diabetes, Acute Cerebral Infarction, Embolic stroke, Emergency treatment of Stroke, Thrombolysis Brief Reports Source Type: research

Chinese Medicine Neuroaid Efficacy on Stroke Recovery: A Double-Blind, Placebo-Controlled, Randomized Study Major Clinical Trial
Conclusions— MLC601 is statistically no better than placebo in improving outcomes at 3 months when used among patients with acute ischemic stroke of intermediate severity. Longer treatment duration and follow-up of participants with treatment initiated after 48 hours may be considered in future studies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00554723.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Chen, C. L. H., Young, S. H. Y., Gan, H. H., Singh, R., Lao, A. Y., Baroque, A. C., Chang, H. M., Hiyadan, J. H. B., Chua, C. L., Advincula, J. M., Muengtaweepongsa, S., Chan, B. P. L., de Silva, H. A., Towanabut, S., Suwanwela, N. C., Poungvarin, N., Cha Tags: Acute Cerebral Infarction, Other Stroke Treatment - Medical Major Clinical Trial Source Type: research

Ideal Cardiovascular Health Metrics and the Risks of Ischemic and Intracerebral Hemorrhagic Stroke Clinical Sciences
Conclusions— We observed a clear inverse gradient relationship between the number of ideal CVH metrics and the risk of stroke in a Chinese population, supporting the importance of ideal health behaviors and factors in stroke prevention.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Zhang, Q., Zhou, Y., Gao, X., Wang, C., Zhang, S., Wang, A., Li, N., Bian, L., Wu, J., Jia, Q., Wu, S., Zhao, X. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Atrial Fibrillation, Stroke Risk, and Warfarin Therapy Revisited: A Population-Based Study Clinical Sciences
Conclusions— AF is more common than present guidelines suggest. The attributable risk of AF for ischemic stroke increases with age and is close to that of hypertension in individuals aged ≥80 years. Because a majority of patients with AF with increased risk for stroke had not received anticoagulation therapy, there is a large potential for improvement.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Bjorck, S., Palaszewski, B., Friberg, L., Bergfeldt, L. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Arrhythmias, clinical electrophysiology, drugs, Epidemiology Clinical Sciences Source Type: research

Pulmonary Embolism in Ischemic Stroke: Clinical Presentation, Risk Factors, and Outcome Stroke
Conclusions In this large cohort study, PE occurred in nearly 1% of AIS patients. PE was more common in patients with severe stroke, history of cancer, previous DVT/PE or acute DVT and associated with lower short- and long-term survival, greater disability, and longer length of stay.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Pongmoragot, J., Rabinstein, A. A., Nilanont, Y., Swartz, R. H., Zhou, L., Saposnik, G., The Investigators of the Registry of the Canadian Stroke Network (RCSN) and University of Toronto Stroke Program for the Stroke Outcomes Research Canada (SORCan [www. Tags: Stroke Source Type: research

Improved Detection of Silent Atrial Fibrillation Using 72-Hour Holter ECG in Patients With Ischemic Stroke: A Prospective Multicenter Cohort Study Clinical Sciences
Conclusions— In unselected survivors of stroke or TIA, 72-hour ECG monitoring is feasible and improves the detection rate of silent paroxysmal AF.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Grond, M., Jauss, M., Hamann, G., Stark, E., Veltkamp, R., Nabavi, D., Horn, M., Weimar, C., Kohrmann, M., Wachter, R., Rosin, L., Kirchhof, P. Tags: Acute Cerebral Infarction, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

Discharge Is a Critical Time to Influence 10-Year Use of Secondary Prevention Therapies for Stroke Clinical Sciences
Conclusions— Prescription of medications at hospital discharge was the strongest predictor of ongoing medication use in survivors of stroke, even at 10 years after stroke. Ensuring that patients with stroke are discharged on optimal medications is likely to improve their long-term management, but further strategies might be required among those who are disadvantaged.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Thrift, A. G., Kim, J., Douzmanian, V., Gall, S. L., Arabshahi, S., Loh, M., Evans, R. G. Tags: Compliance/Adherence, Secondary prevention, Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Impact of BDNF -196 g≯a and BDNF -270 c≯t polymorphisms on stroke rehabilitation outcome: sex and age differences.
Conclusions:BDNF -196 G≯A polymorphism might affect functional outcome of stroke rehabilitation, but this hypothesis needs further verification. PMID: 24722042 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - April 17, 2014 Category: Neurology Authors: Mirowska-Guzel D, Gromadzka G, Mendel T, Janus-Laszuk B, Dzierka J, Sarzynska-Dlugosz I, Czlonkowski A, Czlonkowska A Tags: Top Stroke Rehabil Source Type: research

P-Wave Morphology and the Risk of Incident Ischemic Stroke in the Multi-Ethnic Study of Atherosclerosis Brief Reports
Conclusions— We found an association between baseline P-wave morphology and incident stroke even after accounting for AF. This association may reflect an atrial cardiopathy that leads to stroke in the absence of AF.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Kamel, H., Soliman, E. Z., Heckbert, S. R., Kronmal, R. A., Longstreth, W. T., Nazarian, S., Okin, P. M. Tags: Cerebrovascular disease/stroke, Electrocardiology, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Risk Factors for Stroke Brief Reports Source Type: research

Arteriopathy Diagnosis in Childhood Arterial Ischemic Stroke: Results of the Vascular Effects of Infection in Pediatric Stroke Study Clinical Sciences
Conclusions— Clinical data and follow-up imaging help, yet uncertainty in the diagnosis of childhood arteriopathy remains. This presents a challenge to better understanding the mechanisms underlying these arteriopathies and designing strategies for prevention of childhood arterial ischemic stroke.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Wintermark, M., Hills, N. K., deVeber, G. A., Barkovich, A. J., Elkind, M. S. V., Sear, K., Zhu, G., Leiva-Salinas, C., Hou, Q., Dowling, M. M., Bernard, T. J., Friedman, N. R., Ichord, R. N., Fullerton, H. J., and the VIPS Investigators, Benedict, Fox, L Tags: Stroke in Children and the Young Clinical Sciences Source Type: research

Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia Basic Sciences
Conclusions— Catabolic pathways of muscle tissue are activated after stroke. Impaired feeding, sympathetic overactivation, or infection cannot fully explain this catabolic activation. Wasting of the target muscle of the disrupted innervation correlated to severity of brain injury. Our data indicate the presence of a stroke-specific sarcopenia.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Springer, J., Schust, S., Peske, K., Tschirner, A., Rex, A., Engel, O., Scherbakov, N., Meisel, A., von Haehling, S., Boschmann, M., Anker, S. D., Dirnagl, U., Doehner, W. Tags: Animal models of human disease, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke.
This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered with NCT02065778. PMID: 25126443 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Body Mass Index and Stroke Risk Among Patients With Type 2 Diabetes Mellitus Clinical Sciences
Conclusions— The present study demonstrates an inverse association between BMI and stroke risk among patients with type 2 diabetes mellitus.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Li, W., Katzmarzyk, P. T., Horswell, R., Zhang, Y., Zhao, W., Wang, Y., Johnson, J., Hu, G. Tags: Obesity, Type 2 diabetes, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Can a Novel Clinical Risk Score Improve Pneumonia Prediction in Acute Stroke Care? A UK Multicenter Cohort Study Stroke
Conclusions The ISAN score is a simple tool for predicting SAP in clinical practice. External validation is required in ischemic and hemorrhagic stroke cohorts.
Source: JAHA:Journal of the American Heart Association - January 13, 2015 Category: Cardiology Authors: Smith, C. J., Bray, B. D., Hoffman, A., Meisel, A., Heuschmann, P. U., Wolfe, C. D. A., Tyrrell, P. J., Rudd, A. G., the Intercollegiate Stroke Working Party Group Tags: Stroke Source Type: research

Job Strain and the Risk of Stroke: An Individual-Participant Data Meta-Analysis Brief Reports
Conclusion— Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Fransson, E. I., Nyberg, S. T., Heikkila, K., Alfredsson, L., Bjorner, J. B., Borritz, M., Burr, H., Dragano, N., Geuskens, G. A., Goldberg, M., Hamer, M., Hooftman, W. E., Houtman, I. L., Joensuu, M., Jokela, M., Knutsson, A., Koskenvuo, M., Koskinen, A. Tags: Behavioral/psychosocial - stroke, Epidemiology Brief Reports Source Type: research