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The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer's disease: a Mendelian randomization study
Previous observational studies have reported associations between plasma vitamin C levels, and cardiovascular diseases (CVDs) and Alzheimer's disease (AD); however, no conclusive results have been obtained. We conducted a Mendelian randomization (MR) study to investigate the causality of vitamin C on the risk of nine CVDs [including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), heart failure (HF), stroke, ischemic stroke (IS), and IS subtypes] and Alzheimer's disease.
Source: Clinical Nutrition - September 4, 2021 Category: Nutrition Authors: Lu Chen, Xingang Sun, Zhen Wang, Yunlong Lu, Miao Chen, Yuxian He, Hongfei Xu, Liangrong Zheng Tags: Original article Source Type: research

Frailty syndrome: an emerging clinical problem in the everyday management of clinical arrhythmias. The results of the European Heart Rhythm Association survey
In conclusion, the complex clinical condition in frail patients presenting with arrhythmias warrants an integrated multidisciplinary approach both for the management of rhythm disturbances and for the decision on using CIEDs.
Source: Europace - October 10, 2017 Category: Cardiology Source Type: research

The National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 2010 (NIPPON DATA2010): Objectives, Design, and Population Characteristics.
CONCLUSIONS: We established NIPPON DATA2010 as a cohort study on a representative general Japanese population that covers all of Japan. PMID: 29503381 [PubMed - in process]
Source: Journal of Epidemiology - March 7, 2018 Category: Epidemiology Tags: J Epidemiol Source Type: research

Bound to bleed: How altered albumin binding may dictate warfarin treatment outcome
Publication date: March 2019Source: IJC Heart & Vasculature, Volume 22Author(s): Anke C. Fender, Dobromir DobrevAbstractAlthough non-vitamin-K anticoagulants are now the preferred option for stroke prevention in atrial fibrillation (AF), warfarin is still used in a significant number of patients. Warfarin dosing requirements are susceptible to drug interactions and genetic polymorphisms in metabolising enzymes. Human serum albumin (HSA) is a candidate modifier of warfarin pharmacokinetics, with hypoalbuminemia now shown to correlate with supratherapeutic INR levels and annual bleeding risk. Warfarin is highly bound to HSA,...
Source: IJC Heart and Vasculature - March 27, 2019 Category: Cardiology Source Type: research

Low Vitamin D Levels Predict Left Atrial Thrombus in Nonvalvular Atrial Fibrillation
We determined the association between left atrial (LA) thrombus occurrence and a non-classic risk marker, plasma levels of vitamin D, in atrial fibrillation (AF) patients on continuous non-vitamin K antagonist oral anticoagulant (NOAC) therapy for ≥4 weeks. Low levels of plasma 25-hydroxy vitamin D (25-OHD) are predictive of fatal stroke. Vitamin D has anticoagulant effects on the coagulation cascade, which are indirectly targeted by NOAC therapy. The impact of plasma levels of vitamin D on the rate of LA thrombus detected by transesophagea l echocardiography (TEE) in AF patients is unknown.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 8, 2020 Category: Nutrition Authors: Ozan M. Çakır Source Type: research

Association Of Adipocytokines Serum Levels With Left Atrial Thrombus Formation In Atrial Fibrillation Patients On Oral Anticoagulation (Alert) – A Cross-Sectional Study
Oral anticoagulation is effective for stroke prevention in atrial fibrillation (AF). However, strokes may still occur in high-risk individuals. We conducted a prospective trial to assess the association between adipocytokine serum levels and surrogate parameters for thromboembolic events.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - November 13, 2020 Category: Nutrition Authors: Hermann Blessberger, Patrick Mueller, Hisaki Makimoto, Friederike Hauffe, Anita Meissner, Christopher Gemein, Joern Schmitt, Christian Hamm, Thomas Deneke, Fabian Schiedat, Andreas M ügge, Michael Gabriel, Clemens Steinwender Source Type: research

State-of-the-Art Review: Evidence on Red Meat Consumption and Hypertension Outcomes
Am J Hypertens. 2022 May 13:hpac064. doi: 10.1093/ajh/hpac064. Online ahead of print.ABSTRACTHypertension (HTN) is a well-established risk factor for cardiovascular diseases (CVD), including ischemic heart disease, stroke, heart failure and atrial fibrillation. The prevalence of HTN, as well as mortality rates attributable to HTN, continue to increase, particularly in the United States and among Black populations. The risk of HTN involves a complex interaction of genetics and modifiable risk factors, including dietary patterns. In this regard, there is accumulating evidence that links dietary intake of red meat with a high...
Source: American Journal of Hypertension - May 13, 2022 Category: Cardiology Authors: Tara Shrout Allen Harpreet S Bhatia Alexis C Wood Shabnam R Momin Matthew A Allison Source Type: research

Individual or Familial Diabetes in Relation to Eight Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study
Diabetes is associated with increased risk of certain cardiovascular diseases, yet the causality remains to be determined. Meanwhile, given that first-degree relatives share 50% of genes, the effect of familial diabetes is also worthy of attention. Therefore, we sought to investigate the causal relations of individual or familial diabetes with eight cardiovascular diseases, including myocardial infarction, hypertension, atrial fibrillation, heart failure, cardiac death, pulmonary embolism, transient ischemic attack, and ischemic stroke.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - January 29, 2023 Category: Nutrition Authors: Meng-Jin Hu, Song Hu, Jiang-Shan Tan, Yue-Jin Yang Source Type: research

Registry for Evaluating Healthy Life Expectancy and Long-Term Outcomes after Catheter Ablation of Atrial Fibrillation in the Very Elderly (REHEALTH AF) study: rationale and design of a prospective, multicentre, observational, comparative study
Introduction Data are lacking on the extent to which patients with non-valvular atrial fibrillation (AF) who are aged ≥80 years benefit from ablation treatment. The question pertains especially to patients’ postablation quality of life (QoL) and long-term clinical outcomes. Methods and analysis We are initiating a prospective, registry-based, multicentre observational study that will include patients aged ≥80 years with non-valvular AF who choose to undergo treatment by catheter ablation and, for comparison, such patients who do not choose to undergo ablation (either according to their physician’s advice...
Source: BMJ Open - February 15, 2023 Category: General Medicine Authors: Okumura, Y., Nagashima, K., Watanabe, R., Yokoyama, K., Kato, T., Fukaya, H., Hayashi, H., Nakahara, S., Shimizu, W., Iwasaki, Y.-k., Fujimoto, Y., Mukai, Y., Ejima, K., Otsuka, T., Suzuki, S., Murakami, M., Kimura, M., Harada, M., Koyama, J., Okamatsu, H Tags: Open access, Cardiovascular medicine Source Type: research

Direct Oral Anticoagulants: Laboratory Challenges and Antidotes
In conclusion, although DOACs make long-term anticoagulation safer and more convenient for patients, DOACs pose challenge to all healthcare providers involved in anticoagulation decisions. The key to correct patient management and optimal outcome therefore lies in education.PMID:36807818 | DOI:10.1055/a-1987-3559
Source: Hamostaseologie - February 22, 2023 Category: Hematology Authors: Jan Beyer-Westendorf Christina K öhler Source Type: research

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