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Atrial fibrillation for internists: current practice.
Abstract Atrial fibrillation (AF) has become a global epidemic and puts affected patients at high risk of adverse events. In this review we summarise the current evidence on risk factors and complications of AF, describe current treatment strategies, and outline new fields of research. Current evidence shows that hypertension and obesity are the two most important modifiable risk factors for the development of AF. Patients with AF face an increased stroke risk. Oral anticoagulation reduces this risk substantially. Mainly for reasons of safety and ease of use, non-vitamin K antagonist oral anticoagulants are prefer...
Source: Swiss Medical Weekly - March 8, 2020 Category: General Medicine Authors: Meyre P, Conen D, Osswald S, Kühne M, Meyer-Zürn C Tags: Swiss Med Wkly Source Type: research

I left my smartphone at home and can’t tell if I’m in atrial fibrillation
The enormous impact of atrial fibrillation (AF) on human suffering, health-care utilization, and physician resources is clear to the readers of HeartRhythm. Recent publications have developed 3 alarming trends: (1) the incidence of AF is increasing, perhaps fueled by the obesity epidemic; (2) our ability to treat AF is not improving, at least as assessed by age-adjusted mortality rates postdiagnosis; and (3) health-care costs for treatment of AF are growing exponentially. In reaction to these depressing facts, the tendency to want to learn more about our enemy is only natural. Improvements in bioengineering technology and ...
Source: Heart Rhythm - January 28, 2013 Category: Cardiology Authors: David J. Callans Tags: Editorial Commentary Source Type: research

Atrial fibrillation: Profile and burden of an evolving epidemic in the 21st century
Abstract: Background: Atrial fibrillation (AF) represents an increasing public health challenge with profound social and economic implications.Methods: A comprehensive synthesis and review of the AF literature was performed. Overall, key findings from 182 studies were used to describe the indicative scope and impact of AF from an individual to population perspective.Results: There are many pathways to AF including advancing age, cardiovascular disease and increased levels of obesity/metabolic disorders. The reported population prevalence of AF ranges from 2.3%–3.4% and historical trends reflect increased AF incidence. Es...
Source: International Journal of Cardiology - February 4, 2013 Category: Cardiology Authors: Jocasta Ball, Melinda J. Carrington, John J.V. McMurray, Simon Stewart Tags: Reviews Source Type: research

Ceruloplasmin dysfunction: a key factor in the pathophysiology of atrial fibrillation?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - November 5, 2013 Category: Internal Medicine Authors: Jamie Y Jeremy, Nilima Shukla Tags: Editorial Comment Source Type: research

Emergence of Atrial Repolarization Alternans at Late Stages of Remodeling: The “Second Factor” in Atrial Fibrillation Progression?
This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - January 1, 2014 Category: Cardiology Authors: FADI G. AKAR Tags: Editorial Comment Source Type: research

A formidable “TASK”: Tipping the balance in favor of rhythm control for the management of atrial fibrillation
Atrial fibrillation (AF) is a major public health epidemic that increases the risk of stroke and heart failure.1 Therapeutic approaches for AF include ablation techniques and pharmacologic agents. The goal of the former strategy is to convert AF by burning or freezing foci of arrhythmogenic triggers or imposing anatomical barriers that disrupt the reentrant circuits that maintain AF. An alternative to ablation is the use of pharmacologic strategies that are either curative (when AF is amenable to conversion) or ameliorative (when it is not).
Source: Heart Rhythm - July 17, 2014 Category: Cardiology Authors: Fadi G. Akar Source Type: research

Relationship between body mass index and left atrial appendage thrombus in nonvalvular atrial fibrillation
Abstract Atrial fibrillation and obesity are two major growing epidemics in the United States and globally. Obese people are at the increased risk of developing atrial fibrillation. The contribution of obesity as an independent risk factor for stroke in the setting of atrial fibrillation remains unclear. We tested the hypothesis that non-valvular atrial fibrillation (NVAF) patients with increased body mass index (BMI) would be at increased risk for the development of left atrial appendage thrombus (LAAT). Consecutive, anticoagulation naïve patients with NVAF referred for a transesophageal echocardiogram (TEE) bet...
Source: Journal of Thrombosis and Thrombolysis - August 18, 2015 Category: Hematology Source Type: research

JAMA Cardiology—A New JAMA Network Journal
Cardiovascular disease remains the leading cause of death and disability worldwide, in developed and developing countries. Despite the success in the last decade in reducing heart disease–related mortality in many countries, with aging of the population and persistent cardiovascular risk factors, the burden of hypertension, ischemic heart disease, heart failure, stroke, valvular heart disease, and atrial fibrillation is reaching epidemic proportions worldwide.
Source: JAMA - Journal of the American Medical Association - October 12, 2015 Category: Journals (General) Source Type: research

New journal JAMA Cardiology to debut in 2016
As cardiovascular disease remains the No. 1 cause of death and disability worldwide, a new medical journal will premiere early next year to serve the global cardiology community. JAMA Cardiology—to be led by an internationally renowned cardiologist—will premiere as the 12th journal in the JAMA Network, which includes JAMA and 10 other specialty journals. “The burden of hypertension, ischemic heart disease, heart failure, stroke, valvular heart disease and atrial fibrillation is reaching epidemic proportions worldwide,” writes Howard Bauchner, MD, editor in chief of The JAMA Network, and colleagues in a JAMA edito...
Source: AMA Wire - October 12, 2015 Category: Journals (General) Authors: Amy Farouk Source Type: news

Atrial Fibrillation in Heart Failure: a Therapeutic Challenge of Our Times.
Authors: Batul SA, Gopinathannair R Abstract Atrial fibrillation (AF) and heart failure (HF) are growing cardiovascular disease epidemics worldwide. There has been an exponential increase in the prevalence of AF and HF correlating with an increased burden of cardiac risk factors and improved survival rates in patients with structural heart disease. AF is associated with adverse prognostic outcomes in HF and is most evident in mild-to-moderate left ventricular (LV) dysfunction where the loss of "atrial kick" translates into poorer quality of life and increased mortality. In the absence of underlying structural heart...
Source: Korean Circulation Journal - September 29, 2017 Category: Cardiology Tags: Korean Circ J Source Type: research

Rate or Rhythm Control of Atrial Fibrillation - Pearls for the Internist.
Abstract Atrial fibrillation is an epidemic in Asia that is increasingly prevalent. Apart from stroke risk stratification and management of anticoagulation, physicians managing this group of patients also need to determine an optimal strategy in terms of rate or rhythm control. With new techniques of catheter ablation to maintain patients in sinus rhythm, patients with atrial fibrillation now have more options for treatment, on top of pharmacological methods. This paper aims to review the current evidence for rate and rhythm control in both general patients and subgroups of interest commonly encountered in clinica...
Source: Annals of the Academy of Medicine, Singapore - November 1, 2017 Category: General Medicine Authors: Huang W, Keng FY, Ching CK Tags: Ann Acad Med Singapore Source Type: research

Heart failure and the development of atrial fibrillation in Hispanics, African Americans and non-Hispanic Whites
Atrial fibrillation (AF) is the most common cardiac arrhythmia [1], whose prevalence is increasing [1,2]. It represents a major public health problem and is closely related to stroke, mortality, decreased quality of life and a high health-care cost burden [3]. Heart failure (HF) is a growing epidemic and likely to impact 9 million US adults by 2030 [16]. AF and HF are closely linked [5], sharing similar risk factors with neurohormonal, cellular, extracellular and electrophysiologic changes of one predisposing the other [6 –8].
Source: International Journal of Cardiology - May 22, 2018 Category: Cardiology Authors: Eric Shulman, Tina Shah, Alon Y. Mazori, Jay J. Chudow, Faraj Kargoli, Dmitriy Nevelev, Jorge Romero, Luigi Di Biase, John Fisher, Jay Gross, Kevin J. Ferrick, Andrew Krumerman Source Type: research

Bayes syndrome: Improving risk stratification in chronic heart failure?
The progressive ageing of population is leading to a significant increase of the incidence of heart failure (HF), one of the epidemics of the 21th Century. In addition, atrial fibrillation (AF) is the most common arrhythmia in elderly patients, and is associated with a higher incidence of stroke and mortality. A significant association between HF and AF has been consistently described, and its combination increases morbidity and mortality.
Source: International Journal of Cardiology - June 13, 2018 Category: Cardiology Authors: Albert Ariza-Sol é, Carme Guerrero, Francesc Formiga Tags: Editorial Source Type: research

Age-and-sex stratified prevalence of atrial fibrillation in rural Western India: Results of SMART-India, a population-based screening study
Early detection of Atrial Fibrillation (AF) is a public health priority across the globe because AF-related strokes are preventable. Despite an ongoing stroke epidemic in India, a public health strategy for AF screening and treatment is missing because the epidemiology of AF in India remains poorly defined.
Source: International Journal of Cardiology - December 5, 2018 Category: Cardiology Authors: Apurv Soni, Sunil Karna, Nisha Fahey, Saket Sanghai, Harshil Patil, Shyamsundar Raithatha, Sunil Thanvi, Somashekhar Nimbalkar, Ben Freedman, Jeroan Allison, David D. McManus Source Type: research

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