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Total 2211 results found since Jan 2013.
Top 20 Research Studies of 2022 for Primary Care Physicians
This article summarizes the top 20 research studies of 2022 identified as POEMs (patient-oriented evidence that matters), excluding COVID-19. Statins for primary prevention of cardiovascular disease produce only a small absolute reduction in a person's likelihood of dying (0.6%), having a myocardial infarction (0.7%), or having a stroke (0.3%) over three to six years. Supplemental vitamin D does not reduce the risk of a fragility fracture, even in people with low baseline vitamin D levels or a previous fracture. Selective serotonin reuptake inhibitors are preferred medical therapy for panic disorder, and patients who disco...
Source: American Family Physician - April 13, 2023 Category: Primary Care Authors: Roland Grad Mark H Ebell Source Type: research
Role of the Voltage-Gated Proton Channel Hv1 in Nervous Systems
We describe the recently discovered functions of Hv1 in various neurological diseases, including brain or spinal cord injury, ischemic stroke, demyelinating diseases, and pain. We also summarize the current advances in the discovery and application of Hv1-targeted small molecules in neurological diseases. Finally, we discuss the current limitations of our understanding of Hv1 and suggest future research directions.
Source: Neuroscience Bulletin - April 8, 2023 Category: Neuroscience Source Type: research
Clinical efficacy of botulinum toxin type A in patients with traumatic brain injury, spinal cord injury, or multiple sclerosis: An observational longitudinal study
This study aims to clarify the role of BoNT-A in the context of non-stroke spasticity (NSS). We enrolled 86 patients affected by multiple sclerosis, spinal cord injury, and traumatic brain injury with clinical indication to perform BoNT-A treatment. Subjects were evaluated before injection and after 1, 3, and 6 months. At every visit, spasticity severity using the modified Ashworth scale, pain using the numeric rating scale, QoL using the Euro Qol Group EQ-5D-5L, and the perceived treatment effect using the Global Assessment of Efficacy scale were recorded. In our population BoNT-A demonstrated to have a significant effect...
Source: Frontiers in Neurology - April 6, 2023 Category: Neurology Source Type: research
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Neurologic emergencies can be difficult to diagnose and treat, and are devastating if missed. Stroke is still the number five cause of death in the United States, down from number three a few years ago, and is the leading cause of long-term serious disability. Nonconvulsive status epilepticus is a substantial problem in intensive care units. Traumatic brain injuries from head trauma are a leading cause of post-traumatic stress in many populations. Then we have spine injuries, headache, back pain, infections, and vision problems, which present to emergency departments on a daily basis.
Source: The Journal of Emergency Medicine - April 5, 2023 Category: Emergency Medicine Authors: Edward J. Otten Tags: Book and Other Media Reviews Source Type: research
Burden of disease of chronic pain in Ecuador
CONCLUSIONS: Chronic pain is an important source of burden of disease. It is comparable to other important causes such as headaches, stroke, diabetes and chronic obstructive pulmonary disease, among others. Low back pain, osteoarthritis and other musculoskeletal pain were the biggest contributors given their high prevalence.PMID:36946473 | DOI:10.1080/14737167.2023.2193689
Source: Expert Review of Pharmacoeconomics and Outcomes Research - March 22, 2023 Category: Health Management Authors: Pieralessandro Lasalvia Yaneth Gil-Rojas Diego Rosselli Source Type: research
