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Comparison of Unibody and Non-Unibody Endografts for Abdominal Aortic Aneurysm Repair in Medicare Beneficiaries: The SAFE-AAA Study
CONCLUSIONS: In the SAFE-AAA Study, unibody endografts failed to meet noninferiority compared with non-unibody endografts with respect to aortic reintervention, rupture, and mortality. These data support the urgency of instituting a prospective longitudinal surveillance program for monitoring safety events related to aortic stent grafts.PMID:36866664 | DOI:10.1161/CIRCULATIONAHA.122.062123
Source: Circulation - March 3, 2023 Category: Cardiology Authors: Eric A Secemsky Yang Song Tianyu Sun Carmen Gacchina Johnson Megan Gatski Li Wang Andrew Farb Robert E Lee Aurko Shaw Jiaman Xu Robert W Yeh Source Type: research

As some hail new antibody treatment for Alzheimer ’s, safety and benefit questions persist
In a packed San Francisco conference room with a celebratory atmosphere, upbeat company representatives and scientists yesterday presented detailed clinical trial data on the first Alzheimer’s treatment shown to clearly, albeit modestly, slow the disease’s normal cognitive decline. The antibody therapy has buoyed a field marked by decades of failures. Now, it appears to be on the cusp of being greenlit by the U.S. Food and Drug Administration (FDA). Yet other researchers warn of potential risks, including brain swelling and brain hemorrhages that were linked to the recently disclosed deaths of two trial participants wh...
Source: Science of Aging Knowledge Environment - December 1, 2022 Category: Geriatrics Source Type: research

Associations between long-term air pollution exposure and the incidence of cardiovascular diseases among American older adults
CONCLUSIONS: Long-term exposure to PM2.5, NO2, and warm-season O3 were associated with increased incidence of cardiovascular diseases, even at low pollutant concentration levels. Black people and people with diabetes were found to be vulnerable populations.PMID:36283157 | DOI:10.1016/j.envint.2022.107594
Source: Environment International - October 25, 2022 Category: Environmental Health Authors: Tingfan Jin Qian Di Weeberb J R équia Mahdieh Danesh Yazdi Edgar Castro Tszshan Ma Yifan Wang Haisu Zhang Liuhua Shi Joel Schwartz Source Type: research

Heartbeat: cardiovascular maternal health and disparities in clinical outcomes
Cardiovascular disease continues to account for a high proportion of pregnancy-related deaths in women in the USA. In addition to pre-existing heart disease, gestational hypertension and diabetes, as well as pre-eclampsia and eclampsia, are associated with an increased risk of adverse cardiovascular outcomes both in the short and long-term. In this issue of Heart, Marschner and colleagues1 report an incidence of cardiometabolic conditions (hypertensive disease and diabetes) of 224.3 (95% CI 221.3 to 227.3) per 1000 births among 74 510 women, mean age 26.4 years (SD 5.5) in a cross-sectional study of Medicare patients from ...
Source: Heart - September 12, 2022 Category: Cardiology Authors: Otto, C. M. Tags: Highlights from this issue Source Type: research

E-191 Influence of socioeconomic factors on the development of post-stroke depression in aneurysmal subarachnoid hemorrhage survivors
ConclusionThe overall risk of developing a new depression disorder after aSAH was 16% in this retrospective study. The female sex was close to 4 times and substance use were six and half time more likely to develop new depressive symptoms; therefore, these risk factors should be considered when screening patients for depression after aSAH.Disclosures D. Lim: None. C. Abdi: None. L. George: None. K. Lim: None. M. Amruthur: None. A. Gonzalez: None. K. Prijoles: None. H. Haughn: None. J. Keen: None. E. Federico: None. C. Galang: None. B. Gulek: None. D. Bass: None. R. Meyer: None. D. Coppel: None. C. Kelly: None. L. Kim: None. M. Levitt: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lim, D., Abdi, C., George, L., Lim, K., Amruthur, M., Gonzalez, A., Prijoles, K., Haughn, H., Keen, J., Federico, E., Galang, C., Gulek, B., Bass, D., Meyer, R., Coppel, D., Kelly, C., Kim, L., Levitt, M. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Group based trajectory modeling to assess adherence to oral anticoagulants among atrial fibrillation patients with comorbidities: a retrospective study
ConclusionAdherence to oral anticoagulants is suboptimal. Interventions tailored according to past adherence trajectories may be effective in improving patient ’s adherence.
Source: International Journal of Clinical Pharmacy - July 1, 2022 Category: Drugs & Pharmacology Source Type: research

Norepinephrine reuptake inhibitors and risk of antihypertensive treatment intensification and major adverse cardiovascular events in patients with stable hypertension and depression
ConclusionsAmong patients with stable hypertension and depression, initiation of serotonin norepinephrine reuptake inhibitors had a similar risk of antihypertensive TI and MACE compared to initiation of SSRIs. Future study with a larger sample size is needed to confirm our findings.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 9, 2022 Category: Drugs & Pharmacology Authors: Raj Desai, Haesuk Park, Joshua D. Brown, Rajesh Mohandas, Steven M. Smith Tags: RESEARCH ARTICLE Source Type: research

Health care fragmentation and blood pressure control among adults taking antihypertensive medication
CONCLUSIONS: Fragmented health care may increase the likelihood of aTRH with uncontrolled BP among older Black adults taking antihypertensive medication.PMID:35404546 | DOI:10.37765/ajmc.2022.88837
Source: The American Journal of Managed Care - April 11, 2022 Category: Health Management Authors: Calvin L Colvin Monika M Safford Paul Muntner Lisandro D Colantonio Lisa M Kern Source Type: research

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