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Specialty: Neurology
Condition: Metabolic Syndrome
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Total 75 results found since Jan 2013.
Translation of obstructive sleep apnea pathophysiology and phenotypes to personalized treatment: a narrative review
Obstructive Sleep Apnea (OSA) arises due to periodic blockage of the upper airway (UA) during sleep, as negative pressure generated during inspiration overcomes the force exerted by the UA dilator muscles to maintain patency. This imbalance is primarily seen in individuals with a narrowed UA, attributable to factors such as inherent craniofacial anatomy, neck fat accumulation, and rostral fluid shifts in the supine posture. Sleep-induced attenuation of UA dilating muscle responsiveness, respiratory instability, and high loop gain further exacerbate UA obstruction. The widespread comorbidity profile of OSA, encompassing car...
Source: Frontiers in Neurology - August 24, 2023 Category: Neurology Source Type: research
Uric acid and neurological disease: a narrative review
Hyperuricemia often accompanies hypertension, diabetes, dyslipidemia, metabolic syndrome, and chronic renal disease; it is also closely related to cardiovascular disease. Moreover, several epidemiological studies have linked hyperuricemia and ischemic stroke. However, uric acid may also have neuroprotective effects because of its antioxidant properties. An association between low uric acid levels and neurodegenerative diseases has been suggested, which may be attributed to diminished neuroprotective effects as a result of reduced uric acid. This review will focus on the relationship between uric acid and various neurologic...
Source: Frontiers in Neurology - June 1, 2023 Category: Neurology Source Type: research
Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options
AbstractSleep-disordered breathing (SDB) can be a sequela of stroke caused by vascular injury to vital respiratory centers, cerebral edema, and increased intracranial pressure of space-occupying lesions. Likewise, obstructive sleep apnea (OSA) contributes to increased stroke risk through local mechanisms such as impaired ischemic cerebrovascular response and systemic effects such as promoting atherosclerosis, hypercoagulability, cardiac arrhythmias, vascular-endothelial dysfunction, and metabolic syndrome. The impact of OSA on stroke outcomes has been established, yet it receives less attention in national guidelines on st...
Source: Translational Stroke Research - March 16, 2023 Category: Neurology Source Type: research
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
AbstractIschemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, d...
Source: Translational Stroke Research - October 24, 2022 Category: Neurology Source Type: research
The potential role of insulin resistance in predicting outcome from intravenous thrombolytic therapy
ConclusionInsulin resistance and metabolic syndrome were associated with worse functional outcomes in non-diabetic stroke patients after receiving rt-PA.
Source: Acta Neurologica Belgica - August 20, 2022 Category: Neurology Source Type: research
Determinants of metabolic syndrome and its prognostic implications among stroke patients in Africa: Findings from the Stroke Investigation Research Network (SIREN) study
This study aimed to investigate the determinants of METS and its prognostic implications among Africans with newly diagnosed stroke in the SIREN study.
Source: Journal of the Neurological Sciences - August 8, 2022 Category: Neurology Authors: Abiodun M. Adeoye, Adeseye A. Akintunde, Joshua Akinyemi, Adekunle G. Fakunle, Fred S. Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O. Osaigbovo, Onoja Akpa, Oyedunni Arulogun, Akinkunmi P. Okekunle, O Source Type: research
Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study
ConclusionsThis study provides potential evidence for a causal role of VAT in ischemic stroke and could suggest novel genetical therapeutic strategies for distinct subtypes of ischemic stroke.
Source: Frontiers in Neurology - April 11, 2022 Category: Neurology Source Type: research
High triglyceride is an independent predictor of high on-treatment platelet reactivity in ischemic stroke patients
In this study, we attempted to evaluate the association between TG and high on-treatment platelet reactivity (HTPR) in IS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - March 31, 2022 Category: Neurology Authors: Haoxuan Chen, Yibo Zhan, Zhenzhen Lou, Hui Mao, Changlin Zhang, Xiaojun Li, Guixian Chen, Huiying Ouyang, Zhiping Huang, Longlong Wen, Haoyou Xu, Zequan Zheng, Yuanqi Zhao, Min Zhao Source Type: research
Identification of Risk Factors for Stroke in China: A Meta-Analysis of Prospective Cohort Studies
This study aimed to identify independent risk factors for first occurrence of stroke in Chinese individuals based on prospective cohort studies. Forty prospective cohort studies assessing 1,984,552 individuals were selected for the final meta-analysis. The identified risk factors for stroke in the Chinese population included old age (RR = 1.86, 95%CI: 1.47–2.36), hypertension (RR = 2.76, 95%CI: 2.26–3.37), cardiovascular disease history (RR = 1.98, 95%CI: 1.06–3.69), chronic kidney disease (RR = 1.65, 95%CI: 1.36–2.01), diabetes mellitus (RR = 1.71, 95%CI: 1.34–2.18), metabolic syndrome (RR = 1.59, 95%CI: 1.33–...
Source: Frontiers in Neurology - March 18, 2022 Category: Neurology Source Type: research
Impact of Sarcopenia on Functional Outcomes Among Patients With Mild Acute Ischemic Stroke and Transient Ischemic Attack: A Retrospective Study
ConclusionsIn this study, the prevalence of sarcopenia in patients with stroke was lower than most of previous studies and patients with sarcopenia showed higher likelihood for unfavorable functional outcomes at 90 days after acute ischemic stroke or TIA. Further investigation of the interventions for treating sarcopenia and its impact on the outcome of ischemic stroke patients is needed.
Source: Frontiers in Neurology - March 15, 2022 Category: Neurology Source Type: research
Taking the Obesity Paradox to New Heights in Cerebral Atherosclerosis
Obesity typically worsens many of the major cardiovascular disease (CVD) risk factors, such as elevating blood pressure, worsening dyslipidemia, increasing impaired plasma glucose metabolism (leading to metabolic syndrome and diabetes mellitus), and increasing systemic inflammation, increasing the risk of most CVD, including hypertension, coronary heart disease (CHD), heart failure, atrial fibrillation and cerebrovascular diseases.1 –3 However, in patients with established CVD, many studies published by my colleagues and I and others have demonstrated a consistent paradox, where obese patients with established CVD seem t...
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2022 Category: Neurology Authors: Carl J. Lavie, Salvatore Carbone, Ian J. Neeland Tags: Editorial Source Type: research
Fine-Mapping of the PLCL2 Gene Identifies Candidate Variants Associated With Ischaemic Stroke Risk in Metabolic Syndrome Patients
A genome-wide association study (GWAS) reported PLCL2 on chromosome 3p24. 3 (rs4618210:A>G) as a novel susceptibility locus for myocardial infarction in the Japanese population. As the most common pathological process, atherosclerosis leads to metabolic syndrome (MetS)-related ischaemic stroke (IS) and myocardial infarction. Hypothesizing that polymorphisms of the PLCL2 gene might be associated with the onset and prognosis of IS in MetS patients, we performed the following study in a Chinese Han population. A total of 709 cases (patients with MetS plus IS) and 711 controls (patients with MetS) were enrolled. A fine-mapp...
Source: Frontiers in Neurology - January 20, 2022 Category: Neurology Source Type: research
Increased Stroke Risk in Metabolically Abnormal Normal Weight: a 10-Year Follow-up of 102,037 Participants in China
AbstractThe purpose of this study was to investigate the risks of stroke in subjects with metabolically abnormal normal weight (MANW) in China. We recruited 102,037 participants from the Zhejiang Metabolic Syndrome Cohort and the Kailuan cohort. The mean years of follow-up were 9.9 years. General obesity was defined by body mass index (BMI) ≥ 28, overweight by BMI < 28 and ≥ 24, and normal weight by BMI < 24 and ≥ 18.5. Metabolic abnormality was defined as two or more abnormal components (elevated triglycerides, low high-density lipoprotein cholesterol, elevated systolic blood pressure or di...
Source: Translational Stroke Research - September 6, 2021 Category: Neurology Source Type: research
Association Between Metabolic Syndrome and Asymptomatic Cerebral Arterial Stenosis: A Cross-Sectional Study in Shandong, China
This study explored the association of MetS and its individual components with asymptomatic intracranial arterial stenosis (aICAS) and asymptomatic extracranial arterial stenosis (aECAS) among older Chinese adults. A total of 1988 participants from the Kongcun Town study aged ≥40 years and without a history of stroke were enrolled. The baseline data were obtained via face-to-face interviews. MetS was defined according to International Diabetes Federation criteria. Detection of aICAS was conducted using transcranial Doppler ultrasound, followed by diagnosis via magnetic resonance angiography. The evaluation of aECAS was p...
Source: Frontiers in Neurology - May 12, 2021 Category: Neurology Source Type: research
Concurrency of Early-Age Exposure to Chinese Famine and Diabetes Increases Recurrence of Ischemic Stroke
Conclusions: Concurrency of early-age famine exposure and diabetes mellitus was associated with a higher risk of stroke recurrence within 12 months, and adherence to evidence-based KPI did not reduce the risk significantly.
Source: Frontiers in Neurology - January 20, 2021 Category: Neurology Source Type: research
