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Influence of Metabolic Syndrome and Race on the Relationship between Intensive Blood Pressure Control and Cardiovascular Outcomes in the SPRINT Cohort
ConclusionsIn this analysis the CV benefit of intensive SBP control did not differ among subjects by baseline MetS status, regardless of race/ethnicity.
Source: Diabetes, Obesity and Metabolism - October 12, 2017 Category: Endocrinology Authors: Kathleen Dungan, Timothy E. Craven, Kyaw Soe, Jackson T. Wright, Jan Basile, William E. Haley, Nancy R. Kressin, Uzma Rani, Leonardo Tamariz, Jeff Whittle, Alan Wiggers, Kwame Osei Tags: ORIGINAL ARTICLE Source Type: research

Cardiovascular risk assessment in prediabetic patients in a hypertensive population: The role of cystatin C
Conclusions Prediabetes was associated with an increased risk of CV events, when compared with the non-prediabetic patients. Age and cystatin C were found as significant risk factors for CV events in the prediabetic cohort.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - April 10, 2018 Category: Endocrinology Source Type: research

An update on physical health and economic consequences of overweight and obesity
Publication date: Available online 5 May 2018 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Dinh-Toi Chu, Nguyen Thi Minh Nguyet, Thien Chu Dinh, Nguyen Vu Thai Lien, Khanh-Hoang Nguyen, Vo Truong Nhu Ngoc, Yang Tao, Le Hoang Son, Duc-Hau Le, Vu Bich Nga, Adam Jurgoński, Quoc-Hung Tran, Pham Van Tu, Van-Huy Pham Overweight and obesity (OW and OB) have been on the increase globally and posed health risks to the world’s population of all ages, including pre-born babies, children, adolescents, adults and elderly people, via their comorbid conditions. Excellent examples of com...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 5, 2018 Category: Endocrinology Source Type: research

Bromocriptine-QR therapy for the management of type 2 diabetes mellitus: developmental basis and therapeutic profile summary.
Authors: Raskin P, Cincotta AH Abstract An extended series of studies indicate that endogenous phase shifts in circadian neuronal input signaling to the biological clock system centered within the hypothalamic suprachiasmatic nucleus (SCN) facilitates shifts in metabolic status. In particular, a diminution of the circadian peak in dopaminergic input to the peri-SCN facilitates the onset of fattening, insulin resistance and glucose intolerance while reversal of low circadian peak dopaminergic activity to the peri-SCN via direct timed dopamine administration to this area normalizes the obese, insulin resistant, gluco...
Source: Expert Review of Endocrinology and Metabolism - August 2, 2018 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Cardiovascular risk assessment in prediabetic patients in a hypertensive population: The role of cystatin C
ConclusionsPrediabetes was associated with an increased risk of CV events, when compared with the non-prediabetic patients. Age and cystatin C were found as significant risk factors for CV events in the prediabetic cohort.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 7, 2018 Category: Endocrinology Source Type: research

Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links.
Authors: Zafar U, Khaliq S, Ahmad HU, Manzoor S, Lone KP Abstract Metabolic syndrome (MetS), today a major global public health problem, is a cluster of clinical, metabolic, and biochemical abnormalities, such as central adiposity, hypertension, insulin resistance, and dyslipidemias. These MetS-related traits significantly increase the risk of type 2 diabetes mellitus, adverse cardiac events, stroke, and hepatic steatosis. The pathogenesis of MetS is multifactorial, with the interplay of environmental, nutritional, and genetic factors. Chronic low-grade inflammation together with visceral adipose tissue, adipocyte ...
Source: Hormones - September 2, 2018 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Lifestyle factors and macro- and micro-vascular complications among people with type 2 diabetes in Saudi Arabia
ConclusionsDiabetes complications are common among people with type 2 diabetes in Saudi Arabia. Life style factors such as inadequate physical activity, longer sitting time, obesity, smoking, hypertension, and poor control of blood glucose and lipids should be assimilated into complications prevention program.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 3, 2018 Category: Endocrinology Source Type: research

Chronic kidney disease among US adults with type 2 diabetes and cardiovascular diseases: A national estimate of prevalence by KDIGO 2012 classification
ConclusionsThis study confirms the high prevalence of CKD in patients with multiple comorbidities: T2D and CVD. It also provides estimates of the prevalence of CKD categories based on KDIGO 2012 classification for US adults with T2D.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 3, 2018 Category: Endocrinology Source Type: research

Albuminuric and non-albuminuric patterns of chronic kidney disease in type 2 diabetes
Publication date: Available online 3 November 2018Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Vadim V. Klimontov, Anton I. KorbutAbstractA growing body of evidence supports a shift in the natural history of chronic kidney disease (CKD) in subjects with diabetes. Specifically, normoalbuminuric chronic kidney disease (NA-CKD), which is characterized by a decline in the glomerular filtration rate in the absence of a preceding or accompanying elevation of albuminuria, has become a widely prevalent variant of renal impairment in diabetes. Diabetic women and nonsmoking individuals with better gly...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 3, 2018 Category: Endocrinology Source Type: research

Metabolic syndrome increases cardiovascular risk in a population with prediabetes: A prospective study in a cohort of Chinese adults
ConclusionsAmong the Chinese population with prediabetes, the risk for major CV events was significantly higher in those with MS than those without.
Source: Journal of Diabetes Investigation - November 7, 2018 Category: Endocrinology Authors: Zekai Chen, Shouling Wu, Jianhuan Huang, Jinhuan Yuan, Haojia Chen, Youren Chen Tags: Original Article Source Type: research

Association between the metabolically healthy obese phenotype and the risk of myocardial infarction: results from the Kailuan study.
Conclusions MHO subjects showed a substantially higher risk of MI in comparison with MH-NW subjects. That said, even without measurable metabolic abnormalities, obesity was associated with a higher risk of MI. PMID: 30400019 [PubMed - in process]
Source: European Journal of Endocrinology - November 8, 2018 Category: Endocrinology Authors: Xu Y, Li H, Wang A, Su Z, Yang G, Luo Y, Tao L, Chen S, Wu S, Wang Y, Guo X Tags: Eur J Endocrinol Source Type: research

Serum vitamin E as a significant prognostic factor in patients with dyslipidemia disorders
ConclusionWe found that vitamin E profile was significantly lower in the dyslipidemia subjects. It is generally suggested that vitamin E monitoring might be used as a useful prognostic and therapeutic agent in dyslipidemia disorder.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 14, 2018 Category: Endocrinology Source Type: research

The morphofunctional features of platelets against the background of metabolic syndrome in patients with generalized marginal periodontitis
Conclusion: The presented data provide strong evidence for changes in the morphofunctional state of peripheral blood platelets in patients with generalized marginal periodontitis of mild and moderate degree against the background of metabolic syndrome.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - December 7, 2018 Category: Endocrinology Source Type: research

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