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Association of intradialytic hypertension with future cardiovascular events and mortality in hemodialysis patients: effects of ambulatory blood pressure
CONCLUSIONS: IDHTN patients had higher risk for mortality and cardiovascular outcomes but this risk is at least partly confounded by the elevated BP levels during the interdialytic period.PMID:37302385 | DOI:10.1159/000531477
Source: American Journal of Nephrology - June 11, 2023 Category: Urology & Nephrology Authors: Fotini Iatridi Marieta P Theodorakopoulou Antonios Karpetas Vasiliki Sgouropoulou Areti Georgiou Eleni Karkamani Artemios Karagiannidis Aikaterini Papagianni Pantelis A Sarafidis Source Type: research

The number of valvular insufficiency is a strong predictor of cardiovascular and all-cause mortality in hemodialysis patients
ConclusionsIn maintenance HD patients, the prevalence of VI is prominently high. The number of VI  ≥ 2 is associated with emergency hospitalized for acute heart failure, cardiovascular and all-cause mortality. Combining age, number of VI ≥ 2, and albumin can predict cardiovascular and all-cause mortality.
Source: International Urology and Nephrology - April 3, 2023 Category: Urology & Nephrology Source Type: research

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes
CONCLUSION: Quality of life was impaired in patients starting haemodialysis. A higher C-reactive protein level level was a consistent independent predictor of the majority of worse quality of life. Transferrin saturation ≤ 20% was associated with worse physical component score of quality of life. Baseline quality of life was predictive of all-cause mortality and the primary outcome measure.EUDRACT REGISTRATION NUMBER: 2013-002267-25.PMID:36995528 | PMC:PMC10061401 | DOI:10.1007/s40620-023-01571-6
Source: Journal of Nephrology - March 30, 2023 Category: Urology & Nephrology Authors: Sunil Bhandari Patrick Parfrey Claire White Stefan D Anker Kenneth Farrington Ian Ford Philip A Kalra John J V McMurray Michele Robertson Charles R V Tomson David C Wheeler Iain C Macdougall PIVOTAL Investigators, Committees Source Type: research

Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis
Conclusions The cardiovascular benefits and safety profile of finerenone in participants with stage 4 CKD were consistent with the overall FIDELITY population; this was also the case for albuminuria and the rate of eGFR decline. The effects on the composite kidney outcome were not consistent over time.PMID:36927680 | DOI:10.2215/CJN.0000000000000149
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 17, 2023 Category: Urology & Nephrology Authors: Pantelis Sarafidis Rajiv Agarwal Bertram Pitt Christoph Wanner Gerasimos Filippatos John Boletis Katherine R Tuttle Luis M Ruilope Peter Rossing Robert Toto Stefan D Anker Zhi-Hong Liu Amer Joseph Christiane Ahlers Meike Brinker Robert Lawatscheck George Source Type: research

Causal association of cardiovascular disease with erectile dysfunction: A two ‐sample bidirectional Mendelian randomization analysis
ConclusionsOur results, based on MR, indicated that genetic susceptibility to IS, HF, and CHD was causally associated with ED. These findings can inform prevention and intervention strategies for ED in IS, HF, and CHD patients.This article is protected by copyright. All rights reserved
Source: Andrology - March 9, 2023 Category: Urology & Nephrology Authors: Miaoyong Ye, Jiaxing Chen, Jianxiong Ma, Junwei Wang, Cunming Zhang, Baijun Chen, Zhongbiao Wu, Fan Zhao, Lan Ma Tags: ORIGINAL ARTICLE Source Type: research

Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: A Mendelian Randomization Study
CONCLUSIONS: Genetically predicted FGF-23 levels are not associated with atherosclerotic and nonatherosclerotic cardiovascular diseases, suggesting no important causal link.PODCAST: This article contains a podcast at https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/CJASN/2023_01_10_CJN05080422.mp3.PMID:36719157 | DOI:10.2215/CJN.05080422
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 31, 2023 Category: Urology & Nephrology Authors: Killian Donovan William G Herrington Guillaume Par é Marie Pigeyre Richard Haynes Rebecca Sardell Adam S Butterworth Lasse Folkersen Stefan Gustafsson Qin Wang Colin Baigent Anders M älarstig Michael V Holmes Natalie Staplin SCALLOP Consortium Source Type: research

Proteinuria and Risk for Heart Failure in 55,191 Patients Having History of Cancer
We examined the association of proteinuria with the risk for heart failure (HF) and other cardiovascular disease (CVD) events in patients with prior history of breast, colorectal, or stomach cancer using a nationwide population-based database.METHODS: We conducted this retrospective observation study using the JMDC Claims Database and analyzed 55,191 patients with prior history of breast, colorectal, or stomach cancer. The median age was 54 (48-60) years, and 20,665 participants (37.4%) were men. Using urine dipstick data at baseline, 3,945 and 1,521 participants were categorized as having trace and positive proteinuria, r...
Source: American Journal of Nephrology - December 21, 2022 Category: Urology & Nephrology Authors: Yuta Suzuki Hidehiro Kaneko Akira Okada Katsuhito Fujiu Nobuaki Michihata Taisuke Jo Norifumi Takeda Hiroyuki Morita Kentaro Kamiya Atsuhiko Matsunaga Junya Ako Koichi Node Masaomi Nangaku Hideo Yasunaga Issei Komuro Source Type: research

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