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Total 155 results found since Jan 2013.

Risk of Ischemic and Hemorrhagic Strokes in Occult and Manifest Cancers Clinical Sciences
Conclusions—Cancer, occult and manifest, is associated with increased risks for stroke. The increased risk is linked mainly to cancers related to smoking.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Klaus Kaae Andersen, Tom Skyhoȷ Olsen Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition.
Abstract 20-Hydroxyeicosatetraenoic acid (20-HETE), Cyp4a-derived eicosanoid, is a lipid mediator that promotes tumor growth as well as causing detrimental effects in cerebral circulation. We determined whether concurrent inhibition of cyclooxygenase-2 (COX-2) and 20-HETE affects colon tumor growth and ischemic stroke outcomes. The expression of Cyp4a and COXs and production of 20-HETE and PGE2 were determined in murine colon carcinoma (MC38) cells. We then examined the effects of combined treatment with rofecoxib, a potent COX-2 inhibitor, and HET0016, a potent Cyp4a inhibitor, on the growth and proliferation of ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 2, 2014 Category: Physiology Authors: Zhang Y, Hoda MN, Zheng X, Li W, Luo P, Maddipati KR, Seki T, Ergul A, Wang MH Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition
20-Hydroxyeicosatetraenoic acid (20-HETE), Cyp4a-derived eicosanoid, is a lipid mediator that promotes tumor growth, as well as causing detrimental effects in cerebral circulation. We determined whether concurrent inhibition of cyclooxygenase-2 (COX-2) and 20-HETE affects colon tumor growth and ischemic stroke outcomes. The expression of Cyp4a and COXs and production of 20-HETE and PGE2 were determined in murine colon carcinoma (MC38) cells. We then examined the effects of combined treatment with rofecoxib, a potent COX-2 inhibitor, and HET0016, a potent Cyp4a inhibitor, on the growth and proliferation of MC38 cells. Subse...
Source: AJP: Regulatory, Integrative and Comparative Physiology - September 15, 2014 Category: Physiology Authors: Zhang, Y., Hoda, M. N., Zheng, X., Li, W., Luo, P., Maddipati, K. R., Seki, T., Ergul, A., Wang, M.-H. Tags: Neural Control Source Type: research

Abstract 14: The Influence of Provider Specialty on Anticoagulation Prescription Fills and Stroke Risk in Atrial Fibrillation Patients With History of Cancer Session Title: Poster Session Reception: Young Investigator Award Semi-Finalists
Conclusion: AF patients with cancer were less likely to see a cardiologist, and less likely to fill an anticoagulant prescription than AF patients without cancer. However, cardiology involvement was associated with increased anticoagulant prescription fills and reduced risk of stroke, suggesting a beneficial role for cardiology providers to improve outcomes in AF patients with history of cancer.
Source: Circulation: Cardiovascular Quality and Outcomes - April 5, 2018 Category: Cardiology Authors: ONeal, W. T., Claxton, J., MacLehose, R., Chen, L., Bengtson, L. G., Chamberlain, A. M., Norby, F., Lutsey, P., Alonso, A. Tags: Session Title: Poster Session Reception: Young Investigator Award Semi-Finalists Source Type: research

An Autopsy Case of Lambl's Excrescences with Trousseau Syndrome that Caused Cardioembolic Stroke.
Authors: Hirayama T, Morioka H, Fujiwara H, Iwamoto K, Kiyozuka T, Takeo H, Ikeda K, Kano O Abstract The frequency and risk of embolism by Lambl's excrescences (LEs) remain unclear. We herein report an autopsy case of LEs that caused cardioembolic stroke. A 74-year-old man with colon cancer was hospitalized for ischemic stroke. His D-dimer levels were elevated. Thus, a diagnosis of ischemic stroke with Trousseau syndrome was made. At the autopsy, we found LEs in the aortic valves and thromboembolism of the brain blood vessels. This finding demonstrated that fibrin clots had adhered to the LEs because of coagulation...
Source: Internal Medicine - August 14, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Chemotherapy induced stroke mimic: 5-Fluorouracil encephalopathy fulfilling criteria for tissue plasminogen activator therapy
Stroke mimics, especially those involving chemotherapy related neurotoxicity, can confound the clinical diagnosis of acute stroke. Here we describe the case of a 63year-old male with a recent history of stage IIIC colon cancer who presented with confusion on the second day of modified FOLFOX6 (5-fluorouracil/oxaliplatin) chemotherapy and subsequently received alteplase, tissue plasminogen activator therapy (tPA), for presumed ischemic stroke. Magnetic resonance imaging scans after tPA administration did not reveal evidence of an infarction and the patients' neurological symptoms resolved completely after discontinuation of...
Source: The American Journal of Emergency Medicine - July 6, 2017 Category: Emergency Medicine Authors: May Thuy Nguyen, Robyn Stoianovici, Luigi Brunetti Source Type: research

Want to Prevent Stroke, Diabetes, Cancer? Get Moving … Now!
Worldwide, 81 per cent of school-aged children are not active enough. Photo: WHOBy Baher KamalROME, Feb 2 2017 (IPS)Tired, lazy, bored, laying down long hours watching TV or seated checking your email? Wrong. And dangerous: not enough exercise contributes to cancer, diabetes, depression and other non-communicable diseases. The warning is bold and comes from the United Nations top health organisation, which is urging people to get up and get active.And the risks of inactivity are expanding alarmingly: according to a new document by the World Health Organization (WHO), less and less people are active in many countries – wi...
Source: IPS Inter Press Service - Health - February 2, 2017 Category: Global & Universal Authors: Baher Kamal Tags: Environment Featured Global Headlines Health IPS UN: Inside the Glasshouse TerraViva United Nations Source Type: news

Predictors of unknown cancer in patients with ischemic stroke
AbstractStroke is the second most frequent neurologic finding in postmortem studies of cancer patients. It has also been described as the first expression of an occult cancer. We have studied patients diagnosed with cancer after an ischemic stroke (IS) and we analyze differences with non-tumor patients. Single cohort longitudinal retrospective study of patients admitted to our center with IS diagnosis from 1 January 2012 to 12 December 2014. All patients were followed for 18  months. Patients with transient ischemic infarction or cerebral hemorrhage, active cancer or in the last 5 years, inability to follow-up or absence...
Source: Journal of Neuro-Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

An aspirin a day helps prevent heart attack, stroke and colon cancer
A daily aspirin should be given to 50-year-olds at risk of suffering a heart attack or stroke in the next decade as long as they are not at risk of bleeding, the US Preventive Services Task Force said.
Source: the Mail online | Health - September 15, 2015 Category: Consumer Health News Source Type: news

Well: Ask Well: Taking a Daily Aspirin
Adults ages 50 to 69 who are at high risk for heart attack or stroke should take a daily low-dose aspirin to prevent both heart attacks and strokes as well colorectal cancer.
Source: NYT - May 6, 2016 Category: American Health Authors: RONI CARYN RABIN Tags: Aspirin Colon and Colorectal Cancer Heart Stroke Ask Well Featured Live Source Type: news

A Case Report of Ischemic Stroke in a Patient with Metastatic Gastric Cancer Secondary to Treatment with the Vascular Endothelial Growth Factor Receptor-2 Inhibitor Ramucirumab
Ramucirumab is an antiangiogenesis agent targeting the vascular endothelial growth factor receptor-2 (VEGFR-2), approved to treat advanced gastric and colon cancer. In clinical trials, it was shown to cause a small increase in arterial thromboembolism compared to placebo, including cerebral and myocardial ischemia, which was not statistically significant. Detailed case reports are lacking and we here present one of the first case reports of stroke secondary to ramucirumab-induced in situ thrombosis.Case Rep Oncol 2016;9:317–320
Source: Case Reports in Oncology - June 10, 2016 Category: Cancer & Oncology Source Type: research

Morning Rounds: Colon cancer deaths, stroke rates among women
Dr. Tara Narula joins "CBS This Morning: Saturday" to discuss a surprising and concerning rise in colon cancer death rates among younger Americans, a new study that shows stroke rates are going down for men but not women and a new development in the on-going battle with antibiotic-resistant bacteria.
Source: Health News: CBSNews.com - August 12, 2017 Category: Consumer Health News Source Type: news

Heart Attack May Be Early Sign of Cancer
The risk of a heart attack or stroke rose in patients who would later be diagnosed with cancer.
Source: NYT Health - December 21, 2018 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Heart Stroke Cancer Colon and Colorectal Cancer Lung Cancer Source Type: news