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Cancer: Leukemia
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Total 266 results found since Jan 2013.
Influence of clonal hematopoiesis on non-hematological diseases and aging processes
Inn Med (Heidelb). 2022 Oct 10. doi: 10.1007/s00108-022-01409-6. Online ahead of print.ABSTRACTThe occurrence of clonal hematopoiesis, caused by acquired somatic mutations of leukemia-associated genes in blood stem cells is very common in the population and increases with age. Besides an increased risk of developing myeloid neoplasms, an unexpected causal relationship between clonal hematopoiesis and cardiovascular diseases was recently discovered. Clonal hematopoiesis presents as a new independent and strong risk factor for cardiovascular diseases, such as atherosclerosis, coronary heart disease, heart failure, aortic val...
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Michael A Rieger Source Type: research
Cerebrovascular accident in a child with precursor B-cell acute lymphoblastic leukemia and coronavirus disease 2019: a case report
ConclusionOwing to the link between coronavirus disease 2019 and hematologic cancers with hypercoagulopathy and the tendency of patients with leukemia to have coronavirus disease 2019 complications, children with leukemia as well as suspected coronavirus disease 2019 must be hospitalized to prevent blood clot formation.
Source: Journal of Medical Case Reports - December 6, 2022 Category: General Medicine Source Type: research
Scottish Firefighters Occupational Cancer and Disease Mortality Rates: 2000-2020
ConclusionsUK firefighters suffer significant excess mortality from cancer and other diseases when compared with the general population. Preventative health monitoring and presumptive legislation are urgently required to protect UK firefighters ’ health.
Source: Occupational Medicine - January 10, 2023 Category: Respiratory Medicine Source Type: research
Comparison of Clinical and Molecular Features Between Patients With Essential Thrombocythemia and Early/Prefibrotic Primary Myelofibrosis Presenting With Thrombocytosis in Taiwan
CONCLUSIONS: ET and pre-PMF-T were two distinct disease entities and exhibited different clinical phenotype, genotype, and outcomes.PMID:36857745 | DOI:10.1093/ajcp/aqac173
Source: American Journal of Clinical Pathology - March 1, 2023 Category: Pathology Authors: Ming-Chung Kuo Wen-Yu Chuang Hung Chang Tung-Huei Lin Jin-Hou Wu Tung-Liang Lin Che-Wei Ou Yu-Shin Hung Ting-Yu Huang Ying-Jung Huang Po-Nan Wang Lee-Yung Shih Source Type: research
Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies
CONCLUSIONS: Inverse non-linear dose-response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults. PROSPERO registration number CRD42018095481.PMID:36854652 | DOI:10.1136/bjsports-2022-105669
Source: British Journal of Sports Medicine - February 28, 2023 Category: Sports Medicine Authors: Leandro Garcia Matthew Pearce Ali Abbas Alexander Mok Tessa Strain Sara Ali Alessio Crippa Paddy C Dempsey Rajna Golubic Paul Kelly Yvonne Laird Eoin McNamara Samuel Moore Thiago Herick de Sa Andrea D Smith Katrien Wijndaele James Woodcock Soren Brage Source Type: research
Comparison of Clinical and Molecular Features Between Patients With Essential Thrombocythemia and Early/Prefibrotic Primary Myelofibrosis Presenting With Thrombocytosis in Taiwan
CONCLUSIONS: ET and pre-PMF-T were two distinct disease entities and exhibited different clinical phenotype, genotype, and outcomes.PMID:36857745 | DOI:10.1093/ajcp/aqac173
Source: American Journal of Clinical Pathology - March 1, 2023 Category: Pathology Authors: Ming-Chung Kuo Wen-Yu Chuang Hung Chang Tung-Huei Lin Jin-Hou Wu Tung-Liang Lin Che-Wei Ou Yu-Shin Hung Ting-Yu Huang Ying-Jung Huang Po-Nan Wang Lee-Yung Shih Source Type: research
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Future Directions
This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications.Recent FindingsRecently, a common age-related hematological entity known as CHIP has been identified as the independent risk factor for CVD. CHIP is defined as the presence of clonally expanded blood cells involving leukemogenic mutations without the evidence of malignancy. CHIP is known to increase the...
Source: Current Oncology Reports - March 16, 2023 Category: Cancer & Oncology Source Type: research
Clonal Hematopoiesis of Indeterminate Potential Is Associated With Coronary Microvascular Dysfunction In Early Nonobstructive Coronary Artery Disease
CONCLUSIONS: In humans, we observe patients with CMD are more likely to have CHIP, and nearly one-third of major adverse cardiovascular events in CMD are mediated by CH.PMID:36951061 | DOI:10.1161/ATVBAHA.122.318928
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 23, 2023 Category: Cardiology Authors: Nadia Akhiyat Terra L Lasho Morsaleh Ganji Takumi Toya Chang-Xin Shi Xianfeng Chen Esteban Braggio Ali Ahmad Michel T Corban Keith Stewart Jenna Fernandez Zhuoer Xie Christy Finke Lilach O Lerman Mrinal M Patnaik Amir Lerman Source Type: research
Identifying patterns of neurocognitive dysfunction through direct comparison of children with leukemia, central nervous system tumors, and sickle cell disease
CONCLUSIONS: Use of a common metric to quantify the magnitude and type of neurocognitive dysfunction across at-risk groups of participants by disease shows that participants perform below age-expected norms in multiple domains and experience dysfunction differently than one another. This approach highlights patterns of dysfunction that can inform disease- and domain-specific interventions.PMID:37036272 | DOI:10.1002/pbc.30299
Source: Cancer Control - April 10, 2023 Category: Cancer & Oncology Authors: Claire E Fraley Jamie S Neiman Charlotte R Feddersen Claire James Taylor G Jones Margit Mikkelsen Rachelle Nuss Alyssa M Schlenz Amanda C Winters Adam L Green Bruce E Compas Source Type: research
