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Peripheral artery disease: Update on etiology, pathophysiology, diagnosis and treatment
Med Clin (Barc). 2023 Jul 28:S0025-7753(23)00361-5. doi: 10.1016/j.medcli.2023.06.005. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a condition related to atherosclerosis affecting >200 million people worldwide, and it increases cardiovascular morbidity (mainly from myocardial infarction and stroke) and mortality. Indeed, PAD patients are classified as patients at very high cardiovascular risk. The most common manifestation of PAD is intermittent claudication, which is associated with reduced mobility and leg pain. Nevertheless, asymptomatic PAD is the most frequent form of PAD worldwide; therefore, ...
Source: Atherosclerosis - July 30, 2023 Category: Cardiology Authors: Dar ío Mandaglio-Collados Francisco Mar ín Jos é Miguel Rivera-Caravaca Source Type: research

Elective ascending aortic aneurysm repair outcomes in a nationwide US cohort
Conclusions The overall rate of in-hospital death, stroke and MI is nearly 5% in patients undergoing elective ascending aortic aneurysm repair. Among several predictors, chronic weight loss is associated with the largest increase in the risk of poor outcomes. Higher hospital volume is associated with a lower in-hospital mortality, highlighting the importance to refer patients to high-volume centres while discussing the risks and benefits of proceeding with repair.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Beyer, S. E., Secemsky, E. A., Khabbaz, K., Carroll, B. J. Tags: Aortic and vascular disease Source Type: research

Disturbed Sleep is Not Good for the Heart: A Narrative Review
Curr Cardiol Rev. 2022 Nov 30. doi: 10.2174/1573403X19666221130100141. Online ahead of print.ABSTRACTSleep-related breathing disorders, including obstructive sleep apnea (OSA) and central sleep apnea (CSA), have a major impact on cardiovascular function. It has shown an association with hypertension, coronary artery disease, cardiac arrhythmias, sudden cardiac death, and congestive heart failure (CHF). This review focuses on highlighting the relationship between sleep apnea and CHF. We discuss the underlying pathophysiology which involves the mechanical, neurohormonal, and inflammatory mechanisms; in addition, the similari...
Source: Current Cardiology Reviews - December 1, 2022 Category: Cardiology Authors: Meet Patel Harshani Yarlagadda Shubekshya Upadhyay Ritesh Neupane Umer Qureshi Joseph D Raco Rahul Jain Rohit Jain Source Type: research

Transitioning to GLP-1 RAs and SGLT2 Inhibitors as the First Choice for Managing Cardiometabolic Risk in Type 2 Diabetes
Abstract  Purpose of ReviewThis forward-looking review summarizes existing evidence from cardiovascular outcome trials on cardiometabolic risk-reduction in type 2 diabetes (T2DM) management, with attention to updating and personalizing recommendations from recent diabetes practice guidelines issued by cardiology societies.Recent FindingsT2DM management has shifted towards cardiometabolic outcome improvement rather than purely glycemic control. According to large clinical trials, sodium-glucose cotransporter-2 inhibitors showed robust results in reducing heart failure (HF) hospitalization and chronic kidney disease (CKD) p...
Source: Current Atherosclerosis Reports - November 24, 2022 Category: Cardiology Source Type: research

Obesity paradox and cardiovascular diseases
Curr Cardiol Rev. 2022 May 14. doi: 10.2174/1573403X18666220514150051. Online ahead of print.ABSTRACTThe present review summaries data describing the relationship between obesity and cardiovascular outcomes. Links between obesity and chronic coronary syndromes, acute coronary syndromes, coronary revascularization, ischemic stroke, heart failure, hypertension and atrial fibrillation were evaluated. Data from epidemiological studies, prospective studies with lifestyle modification or medical therapy, and results of the meta-analysis were evaluated. The majority of publications report the presence of an 'obesity paradox'. Acc...
Source: Current Cardiology Reviews - May 16, 2022 Category: Cardiology Authors: Isayeva Ganna Shalimova Anna Source Type: research

Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke
Post-stroke functional recovery is severely impaired by type 2 diabetes (T2D). This is an important clinical problem since T2D is one of the most common diseases. Because weight loss-based strategies have been...
Source: Cardiovascular Diabetology - December 22, 2021 Category: Cardiology Authors: Dimitra Karampatsi, Alexander Zabala, Ulrika Wilhelmsson, Doortje Dekens, Ellen Vercalsteren, Martin Larsson, Thomas Nystr öm, Milos Pekny, Cesare Patrone and Vladimer Darsalia Tags: Original investigation Source Type: research

Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study
CONCLUSION: Weight loss, especially when moving from normal to underweight, was associated with the increased risk of CVD mortality.PMID:34803086 | DOI:10.5551/jat.63191
Source: Journal of Atherosclerosis and Thrombosis - November 22, 2021 Category: Cardiology Authors: Ahmed Arafa Yoshihiro Kokubo Haytham A Sheerah Yukie Sakai Emi Watanabe Jiaqi Li Kyoko Honda-Kohmo Masayuki Teramoto Rena Kashima Masatoshi Koga Source Type: research

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