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Narcissin induces developmental toxicity and cardiotoxicity in zebrafish embryos via Nrf2/HO ‐1 and calcium signaling pathways
In conclusion, here we provide the first evidence that demonstrates narcissin-induced developmental toxicity and cardiotoxicity in zebrafish via Nrf2/HO-1 and calcium signaling pathways for the first time.
Source: Journal of Applied Toxicology - September 18, 2023 Category: Toxicology Authors: Shuo Gao, Chaoyi Zhou, Linhua Hou, Kuo Xu, Yun Zhang, Xue Wang, Jianheng Li, Kechun Liu, Qing Xia Tags: RESEARCH ARTICLE Source Type: research

Acrolein: formation, health hazards and its controlling by dietary polyphenols
Crit Rev Food Sci Nutr. 2023 May 19:1-14. doi: 10.1080/10408398.2023.2214625. Online ahead of print.ABSTRACTAcrolein, a highly reactive toxic aldehyde, is a common dietary and environmental contaminant which can also be generated endogenously. Exposure to acrolein has been positively associated with some pathological conditions, such as atherosclerosis, diabetes mellitus, stroke, and Alzheimer's disease. At the cellular level, acrolein induces various harmful effects, particularly protein adduction and oxidative damages. Polyphenols are a group of secondary plant metabolites ubiquitously presented in fruits, vegetables, an...
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Yue Zhou Wendy Jin Qingli Wu Qian Zhou Source Type: research

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research

Moschus exerted protective activity against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced cell injury in PC12 cells through regulating Nrf-2/ARE signaling pathways
Biomed Pharmacother. 2023 Jan 26;159:114290. doi: 10.1016/j.biopha.2023.114290. Online ahead of print.ABSTRACTThe pivotal characteristics of Alzheimer's disease (AD) are irreversible memory loss and progressive cognitive decline, eventually causing death from brain failure. In the various proposed hypotheses of AD, oxidative stress is also regarded as a symbolic pathophysiologic cascade contributing to brain diseases. Using Chinese herbal medicine may be beneficial for treating and preventing AD. As a rare and valuable animal medicine, Moschus possesses antioxidant and antiapoptotic efficacy and is extensively applied for ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 28, 2023 Category: Drugs & Pharmacology Authors: Danni Xie Ting Deng Zhenwei Zhai Tao Qin Caiyou Song Ying Xu Tao Sun Source Type: research

Potential therapeutics against neurological disorders: Natural products-based drugs
Neurodegenerative disorders, which are defined by the breakdown of neurons over time, are affecting an increasing number of people. Stroke, Alzheimer's, Parkinson's, Multiple Sclerosis, Migraine, and Amyotrophic Lateral Sclerosis are just a few examples of brain disorders that have no cure. Besides, there is a huge demand for drugs that can cure the diseases mentioned above because the majority of the medications we use to treat them only alleviate diseases. Different neurological disorders have responded satisfactorily to the pharmacological effects of medicinal plants. Despite the numerous multiple types of plants in the...
Source: Frontiers in Pharmacology - August 19, 2022 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 27, Pages 4970: Insights into the Explicit Protective Activity of Herbals in Management of Neurodegenerative and Cerebrovascular Disorders
a Gabriela Bungau The longstanding progressive neurodegenerative conditions of the central nervous system arise mainly due to deterioration, degradation and eventual neuronal cell loss. As an individual ages, the irreversible neurodegenerative disorders associated with aging also begin to develop, and these have become exceedingly prominent and pose a significant burden mentally, socially and economically on both the individual and their family. These disorders express several symptoms, such as tremors, dystonia, loss of cognitive functions, impairment of motor activity leading to immobility, loss of memory and many mo...
Source: Molecules - August 4, 2022 Category: Chemistry Authors: Tapan Behl Rashita Makkar Aayush Sehgal Neelam Sharma Sukhbir Singh Mohammed Albratty Asim Najmi Abdulkarim M. Meraya Simona Gabriela Bungau Tags: Review Source Type: research

Strategies for treatment of disease-associated dementia beyond Alzheimer disease: An update
Curr Neuropharmacol. 2022 Apr 11. doi: 10.2174/1570159X20666220411083922. Online ahead of print.ABSTRACTMemory, cognition, dementia, and neurodegeneration are complexly interlinked processes through various mechanistic pathways leading to a range of clinical outcomes. These are strongly associated with pathological conditions like Alzheimer's disease, Parkinson's disease, schizophrenia, stroke and are a growing concern for their timely diagnosis and management. Several cognition-enhancing interventions for management include non-pharmacological interventions like diet, exercise, and physical activity, while pharmacological...
Source: Current Neuropharmacology - April 12, 2022 Category: Drugs & Pharmacology Authors: Khan Sabiya Samim Gopal L Khatik Ashok K Datusalia Source Type: research

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