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Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
CONCLUSION: These findings suggested that Sirt1 may regulate microglial activation and inflammation by targeting the Shh/Gli-1 signaling pathway following OGD/R injury. Schematic representation of Sirt1 regulating the microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury via mediation of Shh/Gli-1 signaling pathway.PMID:36725745 | DOI:10.1007/s11033-022-08167-6
Source: Molecular Biology Reports - February 1, 2023 Category: Molecular Biology Authors: Hongyan Liao Jiagui Huang Jie Liu Huimin Zhu Yue Chen Xuemei Li Jun Wen Qin Yang Source Type: research

Two phosphonium cation-based ionic liquids as lubricant additive to a polyalphaolefin base oil
Publication date: 1 November 2019Source: Journal of Molecular Liquids, Volume 293Author(s): R. González, J.L. Viesca, A. Hernández Battez, M. Hadfield, A. Fernández-González, M. BartoloméAbstractThis paper studies the tribological performance of two phosphonium cation-based ionic liquids: trihexyltetradecylphosphonium bis(2,4,4-trimethylpentyl) phosphinate ([P6,6,6,14][(iC8)2PO2]) and trihexyltetradecylphosphonium bis(2-ethylhexyl) phosphate ([P6,6,6,14][BEHP]), as lubricant additive at 1 wt% to a polyalphaolefin. A comparison of their tribological behavior was made to that of one type of zinc dialkyldithiophosphate...
Source: Journal of Molecular Liquids - August 17, 2019 Category: Molecular Biology Source Type: research

Identification of key transcription factors associated with cerebral ischemia ‑reperfusion injury based on gene‑set enrichment analysis.
Identification of key transcription factors associated with cerebral ischemia‑reperfusion injury based on gene‑set enrichment analysis. Int J Mol Med. 2019 Jun;43(6):2429-2439 Authors: Zhang YY, Wang K, Liu YE, Wang W, Liu AF, Zhou J, Li C, Zhang YQ, Zhang AP, Lv J, Jiang WJ Abstract Cerebral ischemia‑reperfusion injury (CIRI) usually causes detrimental complications following reperfusion therapy in stroke patients. The present study systematically investigated the regulatory mechanism involved in the pathogenesis of CIRI using gene set enrichment analysis of the transient middle cerebral artery...
Source: International Journal of Molecular Medicine - April 26, 2019 Category: Molecular Biology Authors: Zhang YY, Wang K, Liu YE, Wang W, Liu AF, Zhou J, Li C, Zhang YQ, Zhang AP, Lv J, Jiang WJ Tags: Int J Mol Med Source Type: research

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity.
Abstract SUMMARYThe literature review presented here details recent research involving members of the poly(ADP-ribose) polymerase (PARP) family of proteins. Among the 17 recognized members of the family, the human enzyme PARP1 is the most extensively studied, resulting in a number of known biological and metabolic roles. This review is focused on the roles played by PARP enzymes in host-pathogen interactions and in diseases with an associated inflammatory response. In mammalian cells, several PARPs have specific roles in the antiviral response; this is perhaps best illustrated by PARP13, also termed the zinc finge...
Source: Mol Biol Cell - December 22, 2018 Category: Molecular Biology Authors: Brady PN, Goel A, Johnson MA Tags: Microbiol Mol Biol Rev Source Type: research