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Vitamin E supplementation (alone or with other antioxidants) and stroke: a meta-analysis
CONCLUSIONS: Supplementation with vitamin E alone is not associated with stroke reduction. Instead, supplementation of vitamin E with other antioxidants reduces the incidence of ischemic stroke but increases the risk of hemorrhagic stroke, cancelling any beneficial effect derived. Thus, vitamin E is not recommended in stroke prevention.SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42022258259.PMID:37698992 | DOI:10.1093/nutrit/nuad114
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Enrico Maggio Valeria Proietti Bocchini Roberto Carnevale Pasquale Pignatelli Francesco Violi Lorenzo Loffredo Source Type: research

Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study
ConclusionOur study indicated a significant,non-linear, negative association between plasma selenium and first stroke in males but not in females.Trial registrationChiCTR1800017274.
Source: Biology of Sex Differences - May 29, 2021 Category: Biology Source Type: research

Cryptogenic Intracranial Hemorrhagic Strokes Associated with Hypervitaminosis E and Acutely Elevated α-Tocopherol Levels
Objectives: Up to 41% of intracerebral hemorrhages (ICH) are considered cryptogenic despite a thorough investigation to determine etiology. Certain over-the-counter supplements may increase proclivity to bleeding, and we hypothesize that specifically vitamin E may have an association with ICH and acutely elevated serum levels of α-tocopherol. Our aim is to report 3 cases of recently admitted patients with hypervitaminosis E and otherwise cryptogenic ICH. Methods: At our institution between January and December 2018, 179 patients were admitted with ICH with 73 imputed to be “cryptogenic” (without clear etiology as per ...
Source: Journal of Stroke and Cerebrovascular Diseases - March 5, 2020 Category: Neurology Authors: Nicole K. Le, Tigran Kesayan, Jane Y. Chang, David Z. Rose Source Type: research

Stroke warning: Overdosing on this supplement could cause brain bleeding
SUPPLEMENTS are widely used to boost a healthy diet, and vitamin E is often taken for its antioxidant benefits. However, in excess it can lead to a haemorrhagic stroke.
Source: Daily Express - Health - August 2, 2017 Category: Consumer Health News Source Type: news

Biomarkers associated with bleeding risk in the setting of atrial fibrillation.
Conclusions Biomarkers were introduced in clinical practice in order to better estimate the potential risk of haemorrhage in these patients and increase the prognostic impact of clinical risk scores. In the last years this concept is gaining significant importance. PMID: 28721832 [PubMed - as supplied by publisher]
Source: Current Medicinal Chemistry - July 18, 2017 Category: Chemistry Authors: Sideris S, Archontakis S, Latsios G, Lazaros G, Toutouzas K, Tsiamis E, Vavuranakis M, Vlachopoulos C, Gatzoulis K, Tsioufis K, Tousoulis D Tags: Curr Med Chem Source Type: research

Vitamin E Increases Risk for Hemorrhagic Stroke
New research shows that vitamin E supplementation is associated with an increase in risk for hemorrhagic stroke and a decrease in risk for ischemic stroke
Source: BWH News - November 5, 2010 Category: Hospital Management Source Type: news