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Calcifediol supplementation in adults on hemodialysis: a randomized controlled trial
CONCLUSIONS: In adults treated with hemodialysis and who had vitamin D insufficiency, calcifediol supplementation for 24 months had inconclusive effects on mortality and cardiovascular outcomes.TRIAL REGISTRATION NUMBER: NCT01457001.PMID:34173940 | DOI:10.1007/s40620-021-01104-z
Source: Journal of Nephrology - June 26, 2021 Category: Urology & Nephrology Authors: Luigi Morrone Suetonia C Palmer Valeria M Saglimbene Annalisa Perna Giuseppe Cianciolo Domenico Russo Loreto Gesualdo Patrizia Natale Antonio Santoro Sandro Mazzaferro Mario Cozzolino Adamasco Cupisti Marina Di Luca Biagio Di Iorio Giovanni F M Strippoli Source Type: research

Autophagy in diabetic nephropathy: a review
AbstractDiabetes mellitus (DM) is the leading cause of end stage renal disease. 40% of the patients worldwide will require replacement therapy after 20  years of DM worldwide. Early-stage diabetic nephropathy is characterized by hyperfiltration related to hypeglycemia-induced afferent artery vasodilatation with micro-and macroalbuminuria. Later on, proteinuria with arterial hypertension may appear, culminating in glomerular filtration rate (GFR) d ecline and end stage renal disease. Forty percent of diabetic patients develop microvascular and macrovascular complications, with increased risk among patients with genetic pre...
Source: International Urology and Nephrology - July 12, 2020 Category: Urology & Nephrology Source Type: research

Effects of parathyroid hormone and vitamin D supplementation on stroke among patients receiving peritoneal dialysis
Continuous ambulatory peritoneal dialysis (CAPD) patients have a high incidence of stroke and commonly have increased parathyroid hormone levels and vitamin D insufficiency. We seek to investigate the incidenc...
Source: BMC Nephrology - May 18, 2020 Category: Urology & Nephrology Authors: Xiaohan You, Ying Zhou, Jianna Zhang, Qiongxiu Zhou, Yanling Shi, Zhen Su, Chaoshen Chen, Rongrong Shao and Ji Zhang Tags: Research article Source Type: research

Free 25-Vitamin D Is Correlated with Cardiovascular Events in Prevalent Hemodialysis Patients but Not with Markers of Renal Mineral Bone Disease
In conclusion, our study shows that free vitamin D serum concentrations are independently associated with major cardiovascular events in chronic kidney disease patients on dialysis.Kidney Blood Press Res
Source: Kidney and Blood Pressure Research - June 14, 2019 Category: Urology & Nephrology Source Type: research

Effects of Sleepiness on Survival in Japanese Hemodialysis Patients: J-DOPPS Study
Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. We studied the degree of sleepiness in 1,252 adult HD patients (age ≥20 years) recruited into the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS III), using the Japanese version of the Epworth Sleepiness Scale (JESS) questionnaire. Demographic data were presented for three subgroups: low, intermediate, and high JESS score. Cox proportional hazard regre ssion analysis was perform...
Source: Nephron Clinical Practice - October 25, 2017 Category: Urology & Nephrology Source Type: research