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Progressive Central Artery Occlusion, Ophthalmic Artery Occlusion, and Hemispheric Intracranial Thrombosis after COVID-19 mRNA Vaccine Application: Case Report
Thromboembolic events as a result of COVID-19 mRNA vaccination are a rare, though life-threatening complication. In this case report, we describe a 40-year-old female patient who developed central retinal artery and ophthalmic artery occlusion progressing to intracranial thrombosis 3 weeks after vaccination with the Pfizer-BioNTech COVID-19 vaccine. Initially, she presented with progressive acute and painless unilateral vision loss in her left eye. Dilated fundoscopy of left eye showed macular whitening with sparing of the area of cilioretinal artery distribution. Labs revealed a normal erythrocyte sedimentation rate, C-re...
Source: Case Reports in Ophthalmology - April 18, 2023 Category: Opthalmology Source Type: research

Vaccine-related retinal artery occlusion in adults: a review of the current literature
First of all, I am pleased to have an opportunity to discuss our recently published review on vaccine-related retinal artery occlusion (RAO) in adults.1 Publication and reporting bias are well known in medical research,2 and time lag bias is unavoidable in major public healthcare event as if COVID-19 vaccination.3 Our review clearly listed out the literature search methods on search engine and database used (MEDLINE and PubMed), keywords and MeSH terms applied (vaccine retinal artery occlusion), as well as the date of the search (10th January 2022).
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2022 Category: Neurology Authors: Maggie Yeung, Clarice Kai-ying Su, Sunny Chi Lik Au Source Type: research

Isolated and Combined Unilateral Central Retinal Artery and Vein Occlusions After Vaccination. A Review of the Literature
Retinal artery occlusion (RAO), especially central RAO, is a sight-threatening and potentially blinding ophthalmic emergency. Recent publications reported its association with coronavirus disease 2019 (COVID-19) mRNA vaccines. Although rare, vaccines have been linked to ophthalmic complications, and it is of interest to examine the current literature on vaccine-related RAO.
Source: Journal of Stroke and Cerebrovascular Diseases - May 12, 2022 Category: Neurology Authors: Clarice, Kai-ying Su, Sunny, Chi Lik Au Tags: Short Communication Source Type: research

Susac syndrome complicating a SARS-CoV-2 infection
We present a case of a 40-year-old man diagnosed with Susac syndrome after COVID-19, presenting with acute sensorineural hearing loss, encephalopathy, a splenial “snowball-like” lesion, and branch retinal artery occlusions with distal arterial wall hyperintensity. Although the pathophysiology of Susac syndrome remains unclear, this case is in line with the ongoing debate about the influence of SARS-CoV-2 on the human immune system. Corticosteroid treatme nt was initiated, followed by two treatments with rituximab, with clinical improvement of the symptomatology. Maintenance treatment currently consists of mycophenolic ...
Source: Journal of NeuroVirology - November 4, 2021 Category: Neurology Source Type: research

FDA Approves Expanded Peripheral Artery Disease (PAD) Indication for XARELTO ® (rivaroxaban) Plus Aspirin to Include Patients After Lower-Extremity Revascularization (LER) Due to Symptomatic PAD
RARITAN, N.J., August 24, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has approved an expanded peripheral artery disease (PAD) indication for the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) to include patients following recent lower-extremity revascularization (LER) due to symptomatic PAD. The approval is based on data from the Phase 3 VOYAGER PAD study. With this approval, XARELTO® is the first and only therapy indicated to help reduce the risks of major cardiovascular (CV) events in p...
Source: Johnson and Johnson - August 24, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

SARS-CoV-2 Impairs Vision
Conclusions: This mini review shows that impaired vision may be the initial manifestation of COVID-19, that all sections of the visual tract may be affected and causative for visual impairment in COVID-19 patients, and that SARS-CoV-2 manifests along the visual tract with ischemia, focal infection, and immunological reactions.
Source: Journal of Neuro-Ophthalmology - June 1, 2021 Category: Opthalmology Tags: Disease of the Year: COVID-19 Source Type: research

Comments on Coronavirus Positive Patients Presenting with Stroke-Like Symptoms
We read with interest the short communication entitled “Coronavirus Positive Patients Presenting with Stroke-Like Symptoms”,1 it was a case series on stroke presentation over COVID-19 patients. We are particularly interested on patient 10, the one and only one central retinal artery occlusion (CRAO) case secondary to occlusive thrombus in the intern al carotid artery (ICA), who was also highlighted by the authors. CRAO is a blinding ocular emergency, and a harbinger of ischemic cerebrovascular stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Sunny Chi Lik Au, Callie Ka Li Ko Tags: Letter to Editor Source Type: research

The potential role of microvascular pathology in the neurological manifestations of coronavirus infection
We present the hypothesis that pre-existing vascular damage (due to aging, cardiovascular disease, diabetes, hypertension or other conditions) facilitates infiltration of the virus into the central nervous system (CNS), increasing neuro-inflammation and the likelihood o f neurological symptoms. We also discuss the role of a neuroinflammatory cytokine profile in both blood–brain barrier dysfunction and macrovascular disease (e.g. ischemic stroke and thromboembolism). Future studies are needed to better understand the involvement of the microvasculature in coronavi rus neuropathology, and to test the diagnostic potential o...
Source: Fluids and Barriers of the CNS - September 9, 2020 Category: Neuroscience Source Type: research