• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Dietary genistein and 17 β-estradiol implants differentially influence locomotor and cognitive functions following transient focal ischemia in middle-aged ovariectomized rats at different lengths of estrogen deprivation
This study suggests that the neuroprotective effects of dietary genistein on motor and cognitive functions are distinctly influenced by the length of estrogen deprivation following focal ischemia. SIGNIFICANCE: There is an increasing postmenopausal population opting for homeopathic medicines for the management of menopausal symptoms due to the perceived distrust in estrogen use as hormone replacement. Basic and clinical studies support the notion that early, but not delayed, hormone replacement after menopause is beneficial. Furthermore, evidence suggests that delaying hormone replacement augments the detrimental, rather t...
Source: Hormones and Behavior - June 2, 2022 Category: Endocrinology Authors: Anthony Oppong-Gyebi Daniel Metzger Philip H Vann Nathalie Sumien Derek A Schreihofer Source Type: research

Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats.
In this study, ovariectomized rats were treated with genistein (10 mg/kg) or vehicle daily for two weeks before they received middle cerebral artery occlusion (MCAO) and reperfusion. After 72 hours of reperfusion, the neurological function was evaluated by Garcia test, infarct volume was detected by 2,3,5-triphenyltetrazolium chloride staining, and neuronal damage was detected by Nissl staining. In addition, ROS production and the expression of Nrf2, NQO1 and cleaved-Caspase3 in the ischemic penumbra were detected. RESULTS: The results showed that genistein treatment significantly improved the neurological outcome, red...
Source: Neurological Research - April 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study Nutritional epidemiology and public health
Conclusion: Data suggest that natto intake may contribute to the reduction of CVD mortality.
Source: American Journal of Clinical Nutrition - January 31, 2017 Category: Nutrition Authors: Nagata, C., Wada, K., Tamura, T., Konishi, K., Goto, Y., Koda, S., Kawachi, T., Tsuji, M., Nakamura, K. Tags: Nutritional Epidemiology Research Articles Nutritional epidemiology and public health Source Type: research

Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: the Takayama study.
CONCLUSION: Data suggest that natto intake may contribute to the reduction of CVD mortality. PMID: 27927636 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - December 6, 2016 Category: Nutrition Authors: Nagata C, Wada K, Tamura T, Konishi K, Goto Y, Koda S, Kawachi T, Tsuji M, Nakamura K Tags: Am J Clin Nutr Source Type: research

Effects of Estrogen and Phytoestrogen Treatment on an In Vitro Model of Recurrent Stroke on HT22 Neuronal Cell Line.
Abstract An increase of stroke incidence occurs in women with the decline of estrogen levels following menopause. This ischemic damage may recur, especially soon after the first insult has occurred. We evaluated the effects of estrogen and phytoestrogen treatment on an in vitro recurrent stroke model using the HT22 neuronal cell line. HT22 cells were treated with 17β-estradiol or genistein 1 h after the beginning of the first of two oxygen and glucose deprivation/reoxygenation (OGD/R) cycles. During the second OGD, there was a deterioration of some components of the electron transport chain, such as cytochrome c...
Source: Cellular and Molecular Neurobiology - April 7, 2016 Category: Cytology Authors: Morán J, Perez-Basterrechea M, Garrido P, Díaz E, Alonso A, Otero J, Colado E, González C Tags: Cell Mol Neurobiol Source Type: research

Dietary isoflavones, urinary isoflavonoids, and risk of ischemic stroke in women Nutritional epidemiology and public health
Conclusions: A habitually high intake of soy isoflavones may be associated with a modest but significant increase in risk of ischemic stroke in women. However, no association was shown for the urinary excretion of isoflavonoids.
Source: American Journal of Clinical Nutrition - September 1, 2015 Category: Nutrition Authors: Yu, D., Shu, X.-O., Li, H., Yang, G., Cai, Q., Xiang, Y.-B., Ji, B.-T., Franke, A. A., Gao, Y.-T., Zheng, W., Zhang, X. Tags: Nutritional epidemiology and public health Source Type: research

Dietary isoflavones, urinary isoflavonoids, and risk of ischemic stroke in women.
CONCLUSIONS: A habitually high intake of soy isoflavones may be associated with a modest but significant increase in risk of ischemic stroke in women. However, no association was shown for the urinary excretion of isoflavonoids. PMID: 26245809 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - August 5, 2015 Category: Nutrition Authors: Yu D, Shu XO, Li H, Yang G, Cai Q, Xiang YB, Ji BT, Franke AA, Gao YT, Zheng W, Zhang X Tags: Am J Clin Nutr Source Type: research

Genistein: a Boon for Mitigating Ischemic Stroke.
Abstract In last decades, diet and dietary components have been regarded as important strategies to prevent the development or mitigate numerous chronic diseases, including inflammation, cardiovascular pathologies, cancer, etc. One of the most common dietary components of Asian population is soy. A plethora of research shows the promising effect of soy soy-based foodstuffs and genistein, which is one of the predominant isoflavone compounds, in the prevention and mitigation of stroke. Growing evidence shows that genistein, which is a selective estrogen receptor modulator, mitigates ischemic stroke-induced damages t...
Source: Current Topics in Medicinal Chemistry - April 27, 2015 Category: Chemistry Authors: Nabavi SF, Daglia M, Tundis R, Loizzo MR, Sobarzo-Sánchez E, Orhan IE, Nabavi SM Tags: Curr Top Med Chem Source Type: research