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Up-regulation of lncRNA NEAT1 in cerebral ischemic stroke promotes activation of astrocytes by modulation of miR-488-3p/RAC1
Exp Brain Res. 2022 Dec 23. doi: 10.1007/s00221-022-06519-z. Online ahead of print.ABSTRACTWe aim to research the molecular mechanism of lncRNA NEAT1 in the activation of astrocytes in a cerebral ischemia-reperfusion injury model. Mouse model of cerebral ischemia-reperfusion injury was constructed, and shNEAT1 was transfected. The infarct area, brain water content, and neurological deficiency were detected. Immunofluorescence detection and fluorescence in situ hybridization (FISH) assay were processed to detect glial fibrillary acidic protein (GFAP) expression. Astrocyte cells were cultured for oxygen-glucose deprivation/r...
Source: Experimental Brain Research - December 23, 2022 Category: Neuroscience Authors: Haijian Zheng Gai Zhang Guanglan Liu Ling Wang Source Type: research

Knockdown of XIST Attenuates Cerebral Ischemia/Reperfusion Injury Through Regulation of miR-362/ROCK2 Axis
In conclusion, depletion of XIST attenuated I/R-induced neurological impairment and inflammatory response via the miR-362/ROCK2 axis. These findings offer a potential novel strategy for ischemic stroke therapy.PMID:34037903 | DOI:10.1007/s11064-021-03354-6
Source: Neurochemical Research - May 26, 2021 Category: Neuroscience Authors: Jingtao Wang Zhenqiang Fu Menghan Wang Jingjing Lu Hecheng Yang Hong Lu Source Type: research

Revealing sex-specific molecular changes in hypoxia-ischemia induced neural damage and subsequent recovery using zebrafish model
Publication date: Available online 10 September 2019Source: Neuroscience LettersAuthor(s): Tapatee Das, Kalyani Soren, Mounica Yerasi, Arvind Kumar, Sumana ChakravartyAbstractFunctional recovery from hypoxia-ischemia depends on an individual’s response to the ischemic damage and recovery. Many of the neurological disorders, including cerebral stroke have sex-specific characteristics. Deciphering the differential molecular mechanisms of sex-specific recovery from hypoxic-ischemic insult can improve medical practice in the treatment of cerebral stroke. In the present study, we describe the establishment of a sex-specific g...
Source: Neuroscience Letters - September 12, 2019 Category: Neuroscience Source Type: research

The cooking therapy for cognitive rehabilitation of cerebellar damage: A case report and a review of the literature
ConclusionThe comparison of our data with those reported in previous studies confirmed the Schmahmann’s hypothesis on the effectiveness of neurorehabilitation approaches in cerebellar patients acting as external timekeeping of conscious thoughts.Graphical abstractThe cooking therapy framework for the rehabilitation of the cerebellar patients. The patient underwent 18 levels divided into three courses (starter, pasta, and main) X 2 food meals (meat-fish) X 3 levels of difficulty (1°–2°–3° meal). Tomato sauce is the main food, which is prepared each time for every single meal. All cooking levels started with the pre...
Source: Journal of Clinical Neuroscience - October 16, 2018 Category: Neuroscience Source Type: research