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Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank : A Prospective Cohort Study
CONCLUSION: Higher tea intake was associated with lower mortality risk among those drinking 2 or more cups per day, regardless of genetic variation in caffeine metabolism. These findings suggest that tea, even at higher levels of intake, can be part of a healthy diet.PRIMARY FUNDING SOURCE: National Cancer Institute Intramural Research Program.PMID:36037472 | DOI:10.7326/M22-0041
Source: Annals of Internal Medicine - August 29, 2022 Category: Internal Medicine Authors: Maki Inoue-Choi Yesenia Ramirez Marilyn C Cornelis Amy Berrington de Gonz ález Neal D Freedman Erikka Loftfield Source Type: research

Dietary salt reduction; further lowering of target lowers blood pressure but may increase risk
Commentary on: He FJ, Li J, Macgregor GA. Effect of longer-term modest salt reduction on blood pressure. Cochrane Database Syst Rev 2013;(4):CD004937. Context Numerous studies have shown that a high dietary salt intake increases blood pressure (BP) and the risk of cardiovascular events.1 2 Conversely, a moderate and even low-level salt intake lowers BP in a dose-dependent way. Methods He and colleagues have performed a thorough and comprehensive meta-analysis of 34 randomised controlled trials (RCTs) assessing the impact of modest reduction in salt intake with a trial duration of at least 4 weeks. Findings The present...
Source: Evidence-Based Medicine - January 22, 2014 Category: Internal Medicine Authors: Messerli, F. H., Bangalore, S. Tags: Clinical trials (epidemiology), Drugs: cardiovascular system, Drugs: CNS (not psychiatric), Heart failure, Stroke, Hypertension, Diet, Ischaemic heart disease Therapeutics Source Type: research

Mediterranean diet may reduce Alzheimer's risk
This study included 447...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Psaltopoulou, T., Sergentanis, T. N. Tags: Smoking and tobacco, Clinical trials (epidemiology), Dementia, Drugs: CNS (not psychiatric), Stroke, Hypertension, Diet, Memory disorders (psychiatry), Psychiatry of old age, Lipid disorders, Health education, Smoking Therapeutics/Prevention Source Type: research

Trends in Racial/Ethnic and Nativity Disparities in Cardiovascular Health Among Adults Without Prevalent Cardiovascular Disease in the United States, 1988 to 2014.
Conclusion: Cardiovascular health has declined in the United States, racial/ethnic and nativity disparities persist, and decreased disparities seem to be due to worsening cardiovascular health among whites rather than gains among African Americans and Mexican Americans. Multifaceted interventions are needed to address declining population health and persistent health disparities. Primary Funding Source: National Institute of Neurological Disorders and Stroke and National Center for Advancing Translational Science of the National Institutes of Health. PMID: 29554692 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 20, 2018 Category: Internal Medicine Authors: Brown AF, Liang LJ, Vassar SD, Escarce JJ, Merkin SS, Cheng E, Richards A, Seeman T, Longstreth WT Tags: Ann Intern Med Source Type: research

Legacy of Nutritionist Ancel Keys
A diet high in saturated fat increases risk for heart disease and stroke. We know this, but few can recall who first uncovered the connection. It was Ancel Keys — a name to note and remember. Some 60 years ago, he was a luminary in medical science with a reputation that reached ordinary Americans. In 1961, his image graced the cover of TIME magazine. He was the first to promote the health benefits of the Mediterranean diet. An esteemed professor at the Un iversity of Minnesota, Ancel Keys was brilliant, bold, and worldly.
Source: Mayo Clinic Proceedings - February 29, 2020 Category: Internal Medicine Authors: Phillip B. Sparling Tags: Letter to the editor Source Type: research

The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention.
Authors: Trivedi K, Le V, Nelson JR Abstract The high-purity eicosapentaenoic acid (EPA) prescription fish oil-derived omega-3 fatty acid (omega-3), icosapent ethyl (IPE), was recently approved by the United States Food and Drug Administration (FDA) for cardiovascular disease (CVD) prevention in high-risk patients. This approval is based on the 25% CVD event risk reduction observed with IPE in the pre-specified primary composite endpoint (cardiovascular [CV] death, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization, or hospitalization for unstable angina) in the landmark Reduction of Cardio...
Source: Postgraduate Medicine - August 13, 2020 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Egg and cholesterol consumption and mortality from cardiovascular and different causes in the United States: A population-based cohort study
ConclusionsIn this study, intakes of eggs and cholesterol were associated with higher all-cause, CVD, and cancer mortality. The increased mortality associated with egg consumption was largely influenced by cholesterol intake. Our findings suggest limiting cholesterol intake and replacing whole eggs with egg whites/substitutes or other alternative protein sources for facilitating cardiovascular health and long-term survival. Trial registrationClinicalTrials.gov NCT00340015.
Source: PLoS Medicine - February 9, 2021 Category: Internal Medicine Authors: Pan Zhuang Source Type: research

Fish, Cardiovascular Disease, and Mortality
Fish and shellfish (hereafter referred to as fish) are major sources of the dietary long-chain ω-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) and also contain other nutrients, such as vitamin D, riboflavin, iodine, calcium, phosphorus, magnesium, potassium, zinc, and iron. The summed results of observational studies of fish intake, randomized clinical tria ls of fish oil supplements, and associated mechanistic and experimental studies suggest that regular fish consumption may decrease the incidence of myocardial infarction (MI) and coronary heart disease (CHD), with more uncertain effec...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research

The Modified Chronic Kidney Disease Epidemiology Collaboration Equation for the Estimated Glomerular Filtration Rate is Better Associated with Comorbidities than Other Equations in Living Kidney Donors in Japan
Conclusion We found that the eGFR/Jm-CKD-EPI correlated better with comorbidities than the eGFR/Jm-eGFR and eGFR/Jm-MDRD in Japanese LKT donors. We recommend using the eGFR/Jm-CKD-EPI for the initial assessment of the renal function in LKT donor candidates when evaluating the presence of associated comorbidities.PMID:33716291 | DOI:10.2169/internalmedicine.6934-20
Source: Internal Medicine - March 15, 2021 Category: Internal Medicine Authors: Shinichi Nishi Shunske Goto Makiko Mieno Takashi Yagisawa Kenji Yuzawa Source Type: research

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