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Total 554 results found since Jan 2013.
Neuropsychological adverse drug reactions of Remdesivir: analysis using VigiBase, the WHO global database of individual case safety reports
CONCLUSIONS: Our study demonstrates that remdesivir, a novel drug applied to the treatment of COVID-19, does not have a significant association with adverse neurologic or psychiatric reactions in the real-world setting.PMID:34919240 | DOI:10.26355/eurrev_202112_27435
Source: European Review for Medical and Pharmacological Sciences - December 17, 2021 Category: Drugs & Pharmacology Authors: S Lee J W Yang S Y Jung M S Kim D K Yon S W Lee H-C Kang E Dragioti K Tizaoui L Jacob A Koyanagi J-E Salem K Kostev A Lascu J I Shin J H Kim L Smith Source Type: research
Real-time reviews of research findings will help policymakers address global crises such as COVID-19
Real-time reviews of research findings could help policymakers address global crises such as COVID-19, saysthis articlepublished inNature. Living evidence was first developed by Cochrane and an important recommendation for future health emergencies that came out of the recent Cochrane Convenes meetings. According to scientists writing in the peer-reviewed journal Nature, policy missteps will continue to overshadow the global response to COVID-19 because policymakers are overwhelmed with rapidly shifting research evidence. Faced with new challenges such as the Omicron variant, decision-makers can ’t keep up wi...
Source: Cochrane News and Events - December 15, 2021 Category: Information Technology Authors: Lydia Parsonson Source Type: news
Endovascular versus open surgical repair for complicated chronic Type B aortic dissection
CONCLUSIONS: Due to lack of RCTs or CCTs investigating the effectiveness and safety of TEVAR compared to OSR for patients with complicated CBAD, we are unable to provide any evidence to inform decision-making on the optimal intervention for these patients. High-quality RCTs or CCTs addressing this objective are necessary. However, conducting such studies will be challenging for this life-threatening disease.PMID:34905228 | DOI:10.1002/14651858.CD012992.pub2
Source: Cochrane Database of Systematic Reviews - December 14, 2021 Category: General Medicine Authors: Fionnuala Jordan Brian FitzGibbon Edel P Kavanagh Peter McHugh Dave Veerasingam Sherif Sultan Niamh Hynes Source Type: research
Prescription patterns and dosages of antiepileptic drugs in prevalent patients with epilepsy in Taiwan: A nationwide retrospective cross-sectional study
CONCLUSIONS: In Taiwan, valproic acid was the most prescribed AED for prevalent patients with epilepsy. The mean PDDs of most AEDs were lower than the DDDs developed by the World Health Organization.PMID:34864625 | DOI:10.1016/j.yebeh.2021.108450
Source: Epilepsy and Behaviour - December 5, 2021 Category: Neurology Authors: Chun-Yu Liang Kuo-Liang Chiang Liang-Po Hsieh Li-Nien Chien Source Type: research
Intravenous thrombolytic treatment and endovascular thrombectomy for ischaemic wake-up stroke
CONCLUSIONS: In selected patients with acute ischaemic wake-up stroke, both intravenous thrombolytic treatment and endovascular thrombectomy of large vessel occlusion improved functional outcome without increasing the risk of death. However, a possible increased risk of symptomatic intracranial haemorrhage associated with thrombolytic treatment cannot be ruled out. The criteria used for selecting patients to treatment differed between the trials. All studies were relatively small, and six of the seven studies were terminated early. More studies are warranted in order to determine the optimal criteria for selecting patients...
Source: Cochrane Database of Systematic Reviews - December 1, 2021 Category: General Medicine Authors: Melinda B Roaldsen Haakon Lindekleiv Ellisiv B Mathiesen Source Type: research
Information provision for stroke survivors and their carers
CONCLUSIONS: Active information provision may improve stroke-survivor knowledge and quality of life, and may reduce anxiety and depression. However, the reductions in anxiety and depression scores were small and may not be important. In contrast, providing information passively may slightly worsen stroke-survivor anxiety and depression scores, although again the importance of this is unclear. Evidence relating to carers and to other outcomes of passive information provision is generally very uncertain. Although the best way to provide information is still unclear, the evidence is better for strategies that actively involve...
Source: Cochrane Database of Systematic Reviews - November 23, 2021 Category: General Medicine Authors: Thomas F Crocker Lesley Brown Natalie Lam Faye Wray Peter Knapp Anne Forster Source Type: research
